Matches in SemOpenAlex for { <https://semopenalex.org/work/W4225877557> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W4225877557 endingPage "vi88" @default.
- W4225877557 startingPage "vi88" @default.
- W4225877557 abstract "Abstract INTRODUCTION The NIH Revitalization Act, implemented 29 years ago, set to improve the representation of women and minorities in clinical trials. In this study, we investigate the progress made in neuro-oncology in all phase therapeutic clinical trials for neuro-epithelial central nervous system tumors in comparison to their demographic-specific age-adjusted disease incidence and mortality. METHODS Registry study of all published clinical trials for World Health Organization (WHO) defined neuro-epithelial CNS tumors between January 2000 and December 2019. Study participants for trials were obtained from PubMed and ClinicalTrials.gov. Population-based data from the CBTRUS for incidence analyses. SEER-18 Incidence-Based Mortality data was used for mortality analysis. Descriptive statistics, Fisher exact, and c2 tests were used to analyze the data. RESULTS Among 662 published clinical trial articles representing 49, 907 accrued participants, 62.5% of study participants were men and 37.5% were women (P< 0.0001) representing a mortality specific over-accrual for men (P= 0.001) and under-accrual for women (P= 0.001). Whites, Asians, Blacks, and Hispanics represented 91.7%, 1.5%, 2.6%, and 1.7% of trial participants. Compared with their US cancer mortality, Blacks (47% of expected mortality, P=.008), Hispanics (17% of expected mortality, P< .001) and Asians (33% of expected mortality, P< .001) were underrepresented compared with Whites (114% of expected mortality, P< .001). CONCLUSIONS Nearly 30 years since the Revitalization Act, minorities and women are consistently underrepresented when compared with their demographic-specific incidence and mortality in therapeutic clinical trials for neuroepithelial tumors. This study provides a framework for investigating cancer clinical trial accrual and offers guidance regarding workforce factors associated with enrollment of vulnerable patients." @default.
- W4225877557 created "2022-05-05" @default.
- W4225877557 creator A5010436182 @default.
- W4225877557 creator A5014071257 @default.
- W4225877557 creator A5029807840 @default.
- W4225877557 creator A5036396804 @default.
- W4225877557 creator A5038354675 @default.
- W4225877557 creator A5042661172 @default.
- W4225877557 creator A5043293492 @default.
- W4225877557 creator A5051679592 @default.
- W4225877557 creator A5051948022 @default.
- W4225877557 creator A5054361811 @default.
- W4225877557 creator A5075976186 @default.
- W4225877557 creator A5078384857 @default.
- W4225877557 creator A5082065814 @default.
- W4225877557 creator A5087450728 @default.
- W4225877557 date "2021-11-02" @default.
- W4225877557 modified "2023-10-16" @default.
- W4225877557 title "EPID-11. A POPULATION STUDY OF CLINICAL TRIAL ACCRUAL FOR WOMEN AND MINORITIES IN NEURO-ONCOLOGY FOLLOWING THE NIH REVITALIZATION ACT" @default.
- W4225877557 doi "https://doi.org/10.1093/neuonc/noab196.344" @default.
- W4225877557 hasPublicationYear "2021" @default.
- W4225877557 type Work @default.
- W4225877557 citedByCount "0" @default.
- W4225877557 crossrefType "journal-article" @default.
- W4225877557 hasAuthorship W4225877557A5010436182 @default.
- W4225877557 hasAuthorship W4225877557A5014071257 @default.
- W4225877557 hasAuthorship W4225877557A5029807840 @default.
- W4225877557 hasAuthorship W4225877557A5036396804 @default.
- W4225877557 hasAuthorship W4225877557A5038354675 @default.
- W4225877557 hasAuthorship W4225877557A5042661172 @default.
- W4225877557 hasAuthorship W4225877557A5043293492 @default.
- W4225877557 hasAuthorship W4225877557A5051679592 @default.
- W4225877557 hasAuthorship W4225877557A5051948022 @default.
- W4225877557 hasAuthorship W4225877557A5054361811 @default.
- W4225877557 hasAuthorship W4225877557A5075976186 @default.
- W4225877557 hasAuthorship W4225877557A5078384857 @default.
- W4225877557 hasAuthorship W4225877557A5082065814 @default.
- W4225877557 hasAuthorship W4225877557A5087450728 @default.
- W4225877557 hasBestOaLocation W42258775571 @default.
- W4225877557 hasConcept C120665830 @default.
- W4225877557 hasConcept C121332964 @default.
- W4225877557 hasConcept C121608353 @default.
- W4225877557 hasConcept C121955636 @default.
- W4225877557 hasConcept C126322002 @default.
- W4225877557 hasConcept C143998085 @default.
- W4225877557 hasConcept C144024400 @default.
- W4225877557 hasConcept C144133560 @default.
- W4225877557 hasConcept C149923435 @default.
- W4225877557 hasConcept C179755657 @default.
- W4225877557 hasConcept C2776598537 @default.
- W4225877557 hasConcept C2779134260 @default.
- W4225877557 hasConcept C2781426361 @default.
- W4225877557 hasConcept C2908647359 @default.
- W4225877557 hasConcept C4577558 @default.
- W4225877557 hasConcept C535046627 @default.
- W4225877557 hasConcept C61511704 @default.
- W4225877557 hasConcept C71924100 @default.
- W4225877557 hasConcept C74909509 @default.
- W4225877557 hasConcept C99454951 @default.
- W4225877557 hasConceptScore W4225877557C120665830 @default.
- W4225877557 hasConceptScore W4225877557C121332964 @default.
- W4225877557 hasConceptScore W4225877557C121608353 @default.
- W4225877557 hasConceptScore W4225877557C121955636 @default.
- W4225877557 hasConceptScore W4225877557C126322002 @default.
- W4225877557 hasConceptScore W4225877557C143998085 @default.
- W4225877557 hasConceptScore W4225877557C144024400 @default.
- W4225877557 hasConceptScore W4225877557C144133560 @default.
- W4225877557 hasConceptScore W4225877557C149923435 @default.
- W4225877557 hasConceptScore W4225877557C179755657 @default.
- W4225877557 hasConceptScore W4225877557C2776598537 @default.
- W4225877557 hasConceptScore W4225877557C2779134260 @default.
- W4225877557 hasConceptScore W4225877557C2781426361 @default.
- W4225877557 hasConceptScore W4225877557C2908647359 @default.
- W4225877557 hasConceptScore W4225877557C4577558 @default.
- W4225877557 hasConceptScore W4225877557C535046627 @default.
- W4225877557 hasConceptScore W4225877557C61511704 @default.
- W4225877557 hasConceptScore W4225877557C71924100 @default.
- W4225877557 hasConceptScore W4225877557C74909509 @default.
- W4225877557 hasConceptScore W4225877557C99454951 @default.
- W4225877557 hasIssue "Supplement_6" @default.
- W4225877557 hasLocation W42258775571 @default.
- W4225877557 hasLocation W42258775572 @default.
- W4225877557 hasOpenAccess W4225877557 @default.
- W4225877557 hasPrimaryLocation W42258775571 @default.
- W4225877557 hasRelatedWork W1632477623 @default.
- W4225877557 hasRelatedWork W1974042200 @default.
- W4225877557 hasRelatedWork W2040571669 @default.
- W4225877557 hasRelatedWork W2048418690 @default.
- W4225877557 hasRelatedWork W2117121744 @default.
- W4225877557 hasRelatedWork W2328975430 @default.
- W4225877557 hasRelatedWork W2345715974 @default.
- W4225877557 hasRelatedWork W2911740078 @default.
- W4225877557 hasRelatedWork W2965868302 @default.
- W4225877557 hasRelatedWork W3179572266 @default.
- W4225877557 hasVolume "23" @default.
- W4225877557 isParatext "false" @default.
- W4225877557 isRetracted "false" @default.
- W4225877557 workType "article" @default.