Matches in SemOpenAlex for { <https://semopenalex.org/work/W4225884562> ?p ?o ?g. }
- W4225884562 abstract "Pediatric low-grade gliomas (PLGG) are the most common brain tumors diagnosed during childhood and represent a heterogeneous group associating variable molecular abnormalities. To go further and develop specific statistical patterns between tumor molecular background, imaging features, and patient outcome, a retrospective study was performed in a group of non-neurofibromatosis type 1 (non-NF1) grade 1 PLGGs.Seventy-eight children, followed from 2004 to 2017, were retrospectively reported. In this population, we analyzed radiological and molecular parameters. Their therapeutic management comprised surgery or surgery plus chemotherapies.Considering all 78 patients, 59 had only a surgical removal and 19 patients were treated with postoperative chemotherapy. Twelve progressions were reported in the partially resected and chemotherapeutic groups, whereas four deaths occurred only in the highly treated patients. As expected, in the global cohort, PLGG with BRAF p.V600E and/or CDKN2A loss exhibited poor outcomes and we evidenced significant associations between those molecular characteristics and their imaging presentation. In the chemo-treated patients, when associating initial and 6-month magnetic resonance imaging (MRI) parameters to the molecular features, the good risk situations were significantly linked to the presence of a large tumor cyst at diagnosis and the appearance during treatment of a higher cystic proportion that we called cystic conversion.So, additionally to the presence of BRAF p.V600E or CDKN2A deletion in grade 1 PLGGs, the absence on diagnostic MRI of cystic parts and/or cystic conversion at 6-month chemotherapy were significantly linked to a worst prognosis and response to treatment. These imaging features should be considered as prognostic markers in future PLGG studies." @default.
- W4225884562 created "2022-05-05" @default.
- W4225884562 creator A5007672786 @default.
- W4225884562 creator A5008277545 @default.
- W4225884562 creator A5009422843 @default.
- W4225884562 creator A5009835620 @default.
- W4225884562 creator A5012650137 @default.
- W4225884562 creator A5019781329 @default.
- W4225884562 creator A5022713255 @default.
- W4225884562 creator A5050159344 @default.
- W4225884562 creator A5054150398 @default.
- W4225884562 creator A5058304156 @default.
- W4225884562 creator A5059043447 @default.
- W4225884562 creator A5065276381 @default.
- W4225884562 creator A5075551675 @default.
- W4225884562 creator A5080457307 @default.
- W4225884562 creator A5088605513 @default.
- W4225884562 date "2022-04-04" @default.
- W4225884562 modified "2023-10-15" @default.
- W4225884562 title "Retrospective and integrative analyses of molecular characteristics and their specific imaging parameters in pediatric grade 1 gliomas" @default.
- W4225884562 cites W1612891404 @default.
- W4225884562 cites W1781870113 @default.
- W4225884562 cites W1974545426 @default.
- W4225884562 cites W2000624906 @default.
- W4225884562 cites W2018395989 @default.
- W4225884562 cites W2021448795 @default.
- W4225884562 cites W2028785929 @default.
- W4225884562 cites W2051426927 @default.
- W4225884562 cites W2142961863 @default.
- W4225884562 cites W2146267855 @default.
- W4225884562 cites W2149890572 @default.
- W4225884562 cites W2159099714 @default.
- W4225884562 cites W2289448726 @default.
- W4225884562 cites W2296203480 @default.
- W4225884562 cites W2336299726 @default.
- W4225884562 cites W2366536035 @default.
- W4225884562 cites W2510844597 @default.
- W4225884562 cites W2637313766 @default.
- W4225884562 cites W2652551831 @default.
- W4225884562 cites W2678747063 @default.
- W4225884562 cites W2737907665 @default.
- W4225884562 cites W2789793411 @default.
- W4225884562 cites W2893808205 @default.
- W4225884562 cites W2947767395 @default.
- W4225884562 cites W2972559932 @default.
- W4225884562 cites W2982301551 @default.
- W4225884562 cites W2997703943 @default.
- W4225884562 cites W3015449027 @default.
- W4225884562 cites W3026026728 @default.
- W4225884562 cites W3028415293 @default.
- W4225884562 cites W3033591069 @default.
- W4225884562 cites W3088766168 @default.
- W4225884562 cites W3091827932 @default.
- W4225884562 cites W3127229609 @default.
- W4225884562 cites W3158735907 @default.
- W4225884562 doi "https://doi.org/10.1002/pbc.29575" @default.
- W4225884562 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35373885" @default.
- W4225884562 hasPublicationYear "2022" @default.
- W4225884562 type Work @default.
- W4225884562 citedByCount "4" @default.
- W4225884562 countsByYear W42258845622022 @default.
- W4225884562 countsByYear W42258845622023 @default.
- W4225884562 crossrefType "journal-article" @default.
- W4225884562 hasAuthorship W4225884562A5007672786 @default.
- W4225884562 hasAuthorship W4225884562A5008277545 @default.
- W4225884562 hasAuthorship W4225884562A5009422843 @default.
- W4225884562 hasAuthorship W4225884562A5009835620 @default.
- W4225884562 hasAuthorship W4225884562A5012650137 @default.
- W4225884562 hasAuthorship W4225884562A5019781329 @default.
- W4225884562 hasAuthorship W4225884562A5022713255 @default.
- W4225884562 hasAuthorship W4225884562A5050159344 @default.
- W4225884562 hasAuthorship W4225884562A5054150398 @default.
- W4225884562 hasAuthorship W4225884562A5058304156 @default.
- W4225884562 hasAuthorship W4225884562A5059043447 @default.
- W4225884562 hasAuthorship W4225884562A5065276381 @default.
- W4225884562 hasAuthorship W4225884562A5075551675 @default.
- W4225884562 hasAuthorship W4225884562A5080457307 @default.
- W4225884562 hasAuthorship W4225884562A5088605513 @default.
- W4225884562 hasConcept C121608353 @default.
- W4225884562 hasConcept C126322002 @default.
- W4225884562 hasConcept C126838900 @default.
- W4225884562 hasConcept C141071460 @default.
- W4225884562 hasConcept C143409427 @default.
- W4225884562 hasConcept C143998085 @default.
- W4225884562 hasConcept C167135981 @default.
- W4225884562 hasConcept C2776694085 @default.
- W4225884562 hasConcept C2778984943 @default.
- W4225884562 hasConcept C2780265364 @default.
- W4225884562 hasConcept C71924100 @default.
- W4225884562 hasConcept C72563966 @default.
- W4225884562 hasConceptScore W4225884562C121608353 @default.
- W4225884562 hasConceptScore W4225884562C126322002 @default.
- W4225884562 hasConceptScore W4225884562C126838900 @default.
- W4225884562 hasConceptScore W4225884562C141071460 @default.
- W4225884562 hasConceptScore W4225884562C143409427 @default.
- W4225884562 hasConceptScore W4225884562C143998085 @default.
- W4225884562 hasConceptScore W4225884562C167135981 @default.
- W4225884562 hasConceptScore W4225884562C2776694085 @default.
- W4225884562 hasConceptScore W4225884562C2778984943 @default.
- W4225884562 hasConceptScore W4225884562C2780265364 @default.