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- W4225905061 endingPage "110311" @default.
- W4225905061 startingPage "110311" @default.
- W4225905061 abstract "Gut microbial products direct growth, differentiation, and development in animal hosts. However, we lack system-wide understanding of cell-specific responses to the microbiome. We profiled cell transcriptomes from the intestine, and associated tissue, of zebrafish larvae raised in the presence or absence of a microbiome. We uncovered extensive cellular heterogeneity in the conventional zebrafish intestinal epithelium, including previously undescribed cell types with known mammalian homologs. By comparing conventional to germ-free profiles, we mapped microbial impacts on transcriptional activity in each cell population. We revealed intricate degrees of cellular specificity in host responses to the microbiome that included regulatory effects on patterning and on metabolic and immune activity. For example, we showed that the absence of microbes hindered pro-angiogenic signals in the developing vasculature, causing impaired intestinal vascularization. Our work provides a high-resolution atlas of intestinal cellular composition in the developing fish gut and details the effects of the microbiome on each cell type." @default.
- W4225905061 created "2022-05-05" @default.
- W4225905061 creator A5021005439 @default.
- W4225905061 creator A5028668594 @default.
- W4225905061 creator A5059202245 @default.
- W4225905061 creator A5074942230 @default.
- W4225905061 date "2022-02-01" @default.
- W4225905061 modified "2023-10-02" @default.
- W4225905061 title "A cell atlas of microbe-responsive processes in the zebrafish intestine" @default.
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