FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4225907510> ?p ?o ?g. }

• W4225907510 abstract "The level of T cell activation is a better predictor of CD4+ T cell depletion in highly active antiretroviral therapy (HAART) patients than viral load. Artesunate is an artemisinin derivative that has an immunomodulatory effect. This study investigated whether artesunate tablet reduces T cell activation and improves immune reconstitution among patients with suboptimal immune recovery despite receiving long-term effective HAART. This was a randomized prospective parallel open-label trial consisting of 45 participants whose plasma HIV load was effectively suppressed by HAART for >18 months and who had CD4+ T cell counts of <300 cells/μL or an increase of <20% from baseline. The patients were randomized 2:1 into the artesunate group or the control group and received artesunate tablets (orally, 50 mg two times daily) combined with HAART or HAART alone, respectively. T cell subsets, activation markers, clinical symptoms, viral load, and side effects were assessed. By 48 weeks, artesunate tablet did not improve CD4+ T cell recovery or reduce the activation of T cell subsets but induced in a smaller decline in the expression of T cell activation markers among HAART patients with incomplete immune responses. However, artesunate tablet did appear to reduce the level of T cell apoptosis. One subject developed moderate anemia. Long-term use of artesunate tablet is unlikely to produce substantial clinical benefits in patients receiving HAART who exhibit an incomplete immune response." @default.
• W4225907510 created "2022-05-05" @default.
• W4225907510 creator A5012197508 @default.
• W4225907510 creator A5016779382 @default.
• W4225907510 creator A5025684845 @default.
• W4225907510 creator A5037267938 @default.
• W4225907510 date "2021-06-02" @default.
• W4225907510 modified "2023-09-26" @default.
• W4225907510 title "Effects of Artesunate Tablet on Immune Activation and Reconstitution Among Highly Active Antiretroviral Therapy-Treated Patients with Incomplete Immune Responses" @default.
• W4225907510 cites W1945827446 @default.
• W4225907510 cites W1967239571 @default.
• W4225907510 cites W1977485148 @default.
• W4225907510 cites W1986397607 @default.
• W4225907510 cites W1988200868 @default.
• W4225907510 cites W2004865041 @default.
• W4225907510 cites W2006269988 @default.
• W4225907510 cites W2006721694 @default.
• W4225907510 cites W2013104735 @default.
• W4225907510 cites W2016977573 @default.
• W4225907510 cites W2026496537 @default.
• W4225907510 cites W2028016845 @default.
• W4225907510 cites W2048923715 @default.
• W4225907510 cites W2049539466 @default.
• W4225907510 cites W2055140814 @default.
• W4225907510 cites W2064816035 @default.
• W4225907510 cites W2065765217 @default.
• W4225907510 cites W2068928583 @default.
• W4225907510 cites W2079497981 @default.
• W4225907510 cites W2087450881 @default.
• W4225907510 cites W2087529929 @default.
• W4225907510 cites W2095050873 @default.
• W4225907510 cites W2106943116 @default.
• W4225907510 cites W2122483069 @default.
• W4225907510 cites W2136490370 @default.
• W4225907510 cites W2143589197 @default.
• W4225907510 cites W2148976224 @default.
• W4225907510 cites W2153136696 @default.
• W4225907510 cites W2154433199 @default.
• W4225907510 cites W2160919872 @default.
• W4225907510 cites W2167709851 @default.
• W4225907510 cites W2298488851 @default.
• W4225907510 cites W2337591610 @default.
• W4225907510 cites W2399597028 @default.
• W4225907510 cites W2790526544 @default.
• W4225907510 cites W2850655468 @default.
• W4225907510 cites W2886485146 @default.
• W4225907510 cites W2950800147 @default.
• W4225907510 cites W2962207786 @default.
• W4225907510 cites W3001393750 @default.
• W4225907510 cites W3044605691 @default.
• W4225907510 cites W3087625923 @default.
• W4225907510 cites W4244827160 @default.
• W4225907510 doi "https://doi.org/10.1089/aid.2020.0254" @default.
• W4225907510 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33913736" @default.
• W4225907510 hasPublicationYear "2021" @default.
• W4225907510 type Work @default.
• W4225907510 citedByCount "0" @default.
• W4225907510 crossrefType "journal-article" @default.
• W4225907510 hasAuthorship W4225907510A5012197508 @default.
• W4225907510 hasAuthorship W4225907510A5016779382 @default.
• W4225907510 hasAuthorship W4225907510A5025684845 @default.
• W4225907510 hasAuthorship W4225907510A5037267938 @default.
• W4225907510 hasConcept C126322002 @default.
• W4225907510 hasConcept C142462285 @default.
• W4225907510 hasConcept C203014093 @default.
• W4225907510 hasConcept C2522874641 @default.
• W4225907510 hasConcept C2776090121 @default.
• W4225907510 hasConcept C2778048844 @default.
• W4225907510 hasConcept C2778059366 @default.
• W4225907510 hasConcept C2778371730 @default.
• W4225907510 hasConcept C2780648854 @default.
• W4225907510 hasConcept C71924100 @default.
• W4225907510 hasConcept C8891405 @default.
• W4225907510 hasConcept C98274493 @default.
• W4225907510 hasConceptScore W4225907510C126322002 @default.
• W4225907510 hasConceptScore W4225907510C142462285 @default.
• W4225907510 hasConceptScore W4225907510C203014093 @default.
• W4225907510 hasConceptScore W4225907510C2522874641 @default.
• W4225907510 hasConceptScore W4225907510C2776090121 @default.
• W4225907510 hasConceptScore W4225907510C2778048844 @default.
• W4225907510 hasConceptScore W4225907510C2778059366 @default.
• W4225907510 hasConceptScore W4225907510C2778371730 @default.
• W4225907510 hasConceptScore W4225907510C2780648854 @default.
• W4225907510 hasConceptScore W4225907510C71924100 @default.
• W4225907510 hasConceptScore W4225907510C8891405 @default.
• W4225907510 hasConceptScore W4225907510C98274493 @default.
• W4225907510 hasLocation W42259075101 @default.
• W4225907510 hasLocation W42259075102 @default.
• W4225907510 hasOpenAccess W4225907510 @default.
• W4225907510 hasPrimaryLocation W42259075101 @default.
• W4225907510 hasRelatedWork W1488389671 @default.
• W4225907510 hasRelatedWork W1907388817 @default.
• W4225907510 hasRelatedWork W1994344298 @default.
• W4225907510 hasRelatedWork W2035492084 @default.
• W4225907510 hasRelatedWork W2050374169 @default.
• W4225907510 hasRelatedWork W2078785198 @default.
• W4225907510 hasRelatedWork W2802227235 @default.
• W4225907510 hasRelatedWork W3016491832 @default.
• W4225907510 hasRelatedWork W3121778266 @default.
• W4225907510 hasRelatedWork W4221035744 @default.

• next