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- W4225908034 abstract "Preribosomal RNA is selectively transcribed by RNA polymerase (Pol) I in eukaryotes. The yeast transcription factor upstream activating factor (UAF) represses Pol II transcription and mediates Pol I preinitiation complex (PIC) formation at the 35 S ribosomal RNA gene. To visualize the molecular intermediates toward PIC formation, we determined the structure of UAF in complex with native promoter DNA and transcription factor TATA-box-binding protein (TBP). We found that UAF recognizes DNA using a hexameric histone-like scaffold with markedly different interactions compared with the nucleosome and the histone-fold-rich transcription factor IID (TFIID). In parallel, UAF positions TBP for Core Factor binding, which leads to Pol I recruitment, while sequestering it from DNA and Pol II/III–specific transcription factors. Our work thus reveals the structural basis of RNA Pol selection by a transcription factor." @default.
- W4225908034 created "2022-05-05" @default.
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- W4225908034 date "2022-04-22" @default.
- W4225908034 modified "2023-10-16" @default.
- W4225908034 title "Mechanism of RNA polymerase I selection by transcription factor UAF" @default.
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- W4225908034 doi "https://doi.org/10.1126/sciadv.abn5725" @default.
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