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- W4225916400 abstract "Background: aortic valve stenosis is an important clinical condition, with a significant mortality rate in the elderly. Plasma values of alkaline phosphatase (ALP) have been shown to act as a marker of prognosis in different clinical conditions and in the general population. Methods: Plasma levels of alkaline phosphatase were studied in a cohort of patients with aortic valve stenosis, and a five-year survival evaluation was carried out. Results: 24 patients were under study, of which 12 were dead at 5-year follow-up. The median age at baseline evaluation was 79 years (interquartile range, 72-85 years), and 11 patients were of the female sex (13 were male). The median value of ALP, of 83 IU/L, was used to separate patients into two groups; 2 patients died in the group with low ALP values versus 10 patients who died in the group with high ALP values. Using ALP with the same cut-off level, Kaplan Meyer study with log-rank analysis showed a significance level <0.01. Cox regression analysis showed an overall significant result, with a significant level for plasma ALP (significance level 0.03), but not for age, sex or transvalvular gradient (assessed by echocardiography). Conclusions: Elevated plasma ALP is associated to increased mortality risk in aortic valve stenosis patients. This finding may merit evaluation in studies with a larger number of patients." @default.
- W4225916400 created "2022-05-05" @default.
- W4225916400 creator A5087337932 @default.
- W4225916400 date "2022-03-16" @default.
- W4225916400 modified "2023-10-16" @default.
- W4225916400 title "Plasma alkaline phosphatase is associated to mortality risk in aortic valve stenosis patients." @default.
- W4225916400 doi "https://doi.org/10.1101/2022.03.15.22272399" @default.
- W4225916400 hasPublicationYear "2022" @default.
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