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- W4225916403 abstract "The presence of foreign or misplaced nucleic acids is a dangerous signal that triggers innate immune responses by activating cytosolic DNA sensor cyclic GMP-AMP synthase (cGAS) and binding to its downstream signaling effector stimulator of interferon genes (STING). Then the cGAS-STING pathway activation links nucleic acid-sensing to immune responses and pathogenic entities clearance. However, the overactivation of this signaling pathway leads to fatal immune disorders and contributes to the progression of many human inflammatory diseases. Therefore, optimal activation of this pathway is crucial for the elimination of invading pathogens and the maintenance of immune homeostasis. In this review, we will summarize its fundamental roles in initiating host defense against invading pathogens and discuss its pathogenic roles in multiple neuro-inflammatory diseases, such as Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), amyotrophic lateral sclerosis (ALS), multiple sclerosis (MS) and other neurodegenerative diseases." @default.
- W4225916403 created "2022-05-05" @default.
- W4225916403 creator A5030511597 @default.
- W4225916403 creator A5045382404 @default.
- W4225916403 creator A5055196801 @default.
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- W4225916403 creator A5066080636 @default.
- W4225916403 creator A5091166184 @default.
- W4225916403 creator A5091356240 @default.
- W4225916403 date "2022-02-01" @default.
- W4225916403 modified "2023-10-17" @default.
- W4225916403 title "cGAS-STING-mediated IFN-I Response in Host Defense and Neuroinflammatory Diseases" @default.
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