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• W4225919367 abstract "Ganoderma lucidum is a representative white-rot fungus that has great potential to degrade lignocellulose biomass. Laccase is recognized as a class of the most important lignin-degrading enzymes in G. lucidum. However, the comprehensive regulatory mechanisms of laccase are still lacking. Based on the genome sequence of G. lucidum, 15 laccase genes were identified and their encoding proteins were analyzed in this study. All of the laccase proteins are predicted to be multicopper oxidases with conserved copper-binding domains. Most laccase proteins were secreted enzymes in addition to Lac14 in which the signal peptide could not be predicted. The activity of all laccases showed the highest level at pH 3.0 or pH 7.0, with total laccase activity of approximately 200 U/mg protein. Silencing PacC resulted in a 5.2 fold increase in laccase activity compared with WT. Five laccase genes (lac1, lac6, lac9, lac10 and lac14) showed an increased transcription levels (approximately 1.5-5.6 fold) in the PacC-silenced strains versus that in WT, while other laccase genes were downregulated or unchanged. The extracellular pH value was about 3.1, which was more acidic in the PacC-silenced strains than in the WT (pH 3.5). Moreover, maintaining the fermentation pH resulted in a downregulation of laccase activity which is induced by silencing PacC. Our findings indicate that in addition to its function in acidification of environmental pH, PacC plays an important role in regulating laccase activity in fungi." @default.
• W4225919367 created "2022-05-05" @default.
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• W4225919367 date "2022-01-06" @default.
• W4225919367 modified "2023-10-09" @default.
• W4225919367 title "Improvement of laccase activity by silencing PacC in Ganoderma lucidum" @default.
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• W4225919367 doi "https://doi.org/10.1007/s11274-021-03216-x" @default.
• W4225919367 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34989903" @default.
• W4225919367 hasPublicationYear "2022" @default.
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