Matches in SemOpenAlex for { <https://semopenalex.org/work/W4225935494> ?p ?o ?g. }
- W4225935494 abstract "To elucidate the complex physiological process of testis development and spermatogenesis in Sika deer, this study evaluated the changes of miRNA and mRNA profiles in the four developmental stages of testis in the juvenile (1-year-old), adolescence (3-year-old), adult (5-year-old), and aged (10-year-old) stages. The results showed that a total of 198 mature, 66 novel miRNAs, and 23,558 differentially expressed (DE) unigenes were obtained; 14,918 (8,413 up and 6,505 down), 4,988 (2,453 up and 2,535 down), and 5,681 (2,929 up and 2,752 down) DE unigenes, as well as 88 (43 up and 45 down), 102 (44 up and 58 down), and 54 (18 up and 36 down) DE miRNAs were identified in 3- vs. 1-, 5- vs. 3-, and 10- vs. 5-year-old testes, respectively. By integrating miRNA and mRNA expression profiles, we predicted 10,790 mRNA-mRNA and 69,883 miRNA-mRNA interaction sites. The target genes were enriched by GO and KEGG pathways to obtain DE mRNA (IGF1R, ALKBH5, Piwil, HIF1A, BRDT, etc.) and DE miRNA (miR-140, miR-145, miR-7, miR-26a, etc.), which play an important role in testis development and spermatogenesis. The data show that DE miRNAs could regulate testis developmental and spermatogenesis through signaling pathways, including the MAPK signaling pathway, p53 signaling pathway, PI3K-Akt signaling pathway, Hippo signaling pathway, etc. miR-140 was confirmed to directly target mutant IGF1R-3'UTR by the Luciferase reporter assays. This study provides a useful resource for future studies on the role of miRNA regulation in testis development and spermatogenesis." @default.
- W4225935494 created "2022-05-05" @default.
- W4225935494 creator A5002543434 @default.
- W4225935494 creator A5009927645 @default.
- W4225935494 creator A5042393474 @default.
- W4225935494 creator A5043070856 @default.
- W4225935494 creator A5048279362 @default.
- W4225935494 creator A5048995986 @default.
- W4225935494 creator A5056297363 @default.
- W4225935494 creator A5059216253 @default.
- W4225935494 creator A5059238197 @default.
- W4225935494 creator A5065172118 @default.
- W4225935494 creator A5073746039 @default.
- W4225935494 creator A5078122001 @default.
- W4225935494 creator A5079278204 @default.
- W4225935494 creator A5085371677 @default.
- W4225935494 creator A5087698356 @default.
- W4225935494 creator A5088141758 @default.
- W4225935494 date "2022-04-05" @default.
- W4225935494 modified "2023-09-30" @default.
- W4225935494 title "Comparison of miRNA and mRNA Expression in Sika Deer Testes With Age" @default.
- W4225935494 cites W144423133 @default.
- W4225935494 cites W1522985800 @default.
- W4225935494 cites W1843736399 @default.
- W4225935494 cites W1970306865 @default.
- W4225935494 cites W1979815139 @default.
- W4225935494 cites W1985673772 @default.
- W4225935494 cites W1986205831 @default.
- W4225935494 cites W1987245339 @default.
- W4225935494 cites W1994251361 @default.
- W4225935494 cites W1994478098 @default.
- W4225935494 cites W2002414595 @default.
- W4225935494 cites W2006489768 @default.
- W4225935494 cites W2010123565 @default.
- W4225935494 cites W2014551385 @default.
- W4225935494 cites W2018603404 @default.
- W4225935494 cites W2021787411 @default.
- W4225935494 cites W2026844931 @default.
- W4225935494 cites W2027859640 @default.
- W4225935494 cites W2033082106 @default.
- W4225935494 cites W2038774738 @default.
- W4225935494 cites W2039776069 @default.
- W4225935494 cites W2048144983 @default.
- W4225935494 cites W2053834034 @default.
- W4225935494 cites W2054970102 @default.
- W4225935494 cites W2055923228 @default.
- W4225935494 cites W2056993481 @default.
- W4225935494 cites W2065226274 @default.
- W4225935494 cites W2070053574 @default.
- W4225935494 cites W2077689619 @default.
- W4225935494 cites W2078252393 @default.
- W4225935494 cites W2082634826 @default.
- W4225935494 cites W2085816363 @default.
- W4225935494 cites W2086017543 @default.
- W4225935494 cites W2091125096 @default.
- W4225935494 cites W2097100969 @default.
- W4225935494 cites W2099516845 @default.
- W4225935494 cites W2100802885 @default.
- W4225935494 cites W2109747123 @default.
- W4225935494 cites W2114044152 @default.
- W4225935494 cites W2117533395 @default.
- W4225935494 cites W2121580962 @default.
- W4225935494 cites W2124104364 @default.
- W4225935494 cites W2124871651 @default.
- W4225935494 cites W2127370867 @default.
- W4225935494 cites W2128256249 @default.
- W4225935494 cites W2136943381 @default.
- W4225935494 cites W2138626530 @default.
- W4225935494 cites W2140958036 @default.
- W4225935494 cites W2153101998 @default.
- W4225935494 cites W2158318580 @default.
- W4225935494 cites W2160491878 @default.
- W4225935494 cites W2165556478 @default.
- W4225935494 cites W2168003742 @default.
- W4225935494 cites W2168405256 @default.
- W4225935494 cites W2191062646 @default.
- W4225935494 cites W2264108830 @default.
- W4225935494 cites W2319235871 @default.
- W4225935494 cites W2323505719 @default.
- W4225935494 cites W2399287961 @default.
- W4225935494 cites W2564388338 @default.
- W4225935494 cites W2567346568 @default.
- W4225935494 cites W2588828267 @default.
- W4225935494 cites W2610038606 @default.
- W4225935494 cites W2618563520 @default.
- W4225935494 cites W2737388686 @default.
- W4225935494 cites W2743944639 @default.
- W4225935494 cites W2756422827 @default.
- W4225935494 cites W2768143155 @default.
- W4225935494 cites W2771787495 @default.
- W4225935494 cites W2781913855 @default.
- W4225935494 cites W2789804236 @default.
- W4225935494 cites W2789846580 @default.
- W4225935494 cites W2797804835 @default.
- W4225935494 cites W2799754057 @default.
- W4225935494 cites W2801317597 @default.
- W4225935494 cites W2806503798 @default.
- W4225935494 cites W2811007098 @default.
- W4225935494 cites W2884456048 @default.
- W4225935494 cites W2897709111 @default.