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- W4225943522 abstract "Pairs of interacting transcription factors (TFs) have previously been shown to bind to enhancers and promoters and contribute to their physical interactions. However, to date, we have limited knowledge about such TF pairs. To fill this void, we systematically studied the co-occurrence of TF-binding motifs in interacting enhancer-promoter (EP) pairs in seven human cell lines. We discovered 423 motif pairs that significantly co-occur in enhancers and promoters of interacting EP pairs. We demonstrated that these motif pairs are biologically meaningful and significantly enriched with motif pairs of known interacting TF pairs. We also showed that the identified motif pairs facilitated the discovery of the interacting EP pairs. The developed pipeline, EPmotifPair, together with the predicted motifs and motif pairs, is available at https://doi.org/10.6084/m9.figshare.14192000. Our study provides a comprehensive list of motif pairs that may contribute to EP physical interactions, which facilitate generating meaningful hypotheses for experimental validation." @default.
- W4225943522 created "2022-05-05" @default.
- W4225943522 creator A5025241501 @default.
- W4225943522 creator A5034418164 @default.
- W4225943522 creator A5053178146 @default.
- W4225943522 date "2022-02-07" @default.
- W4225943522 modified "2023-09-30" @default.
- W4225943522 title "A systematic study of motif pairs that may facilitate enhancer–promoter interactions" @default.
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- W4225943522 doi "https://doi.org/10.1515/jib-2021-0038" @default.
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