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- W4225971917 abstract "Vaccination is a standout preventive measure to combat neosporosis among cattle herds. The present in silico study was done to evaluate the physicochemical properties and potent immunogenic epitopes of N. caninum SRS2 protein as a possible vaccine candidate. Web-based tools were used to predict physicochemical properties, antigenicity, allergenicity, solubility, posttranslational modification (PTM) sites, transmembrane domains and signal peptide, and secondary and tertiary structures as well as intrinsically disordered regions, followed by identification and screening of potential linear and conformational B-cell epitopes and those peptides having affinity to bind mouse major histocompatibility complex (MHC) and cytotoxic T lymphocyte (CTL). The protein had 401 residues with a molecular weight of 42 kDa, representing aliphatic index of 69.35 (thermotolerant) and GRAVY score of -0.294 (hydrophilic). There were 53 PTM sites without a signal peptide in the sequence. Secondary structure comprised mostly by extended strand, followed by helices and coils. The Ramachandran plot of the refined model showed 90.2%, 8.8%, 0.5%, and 0.5% residues in the favored, additional allowed, generously allowed, and disallowed regions, correspondingly. Additionally, various potential B-cell (linear and conformational), CTL, and MHC-binding epitopes were predicted for N. caninum SRS2. These epitopes could be further utilized in the multiepitope vaccine constructs directed against neosporosis." @default.
- W4225971917 created "2022-05-05" @default.
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- W4225971917 date "2022-04-06" @default.
- W4225971917 modified "2023-09-26" @default.
- W4225971917 title "Neospora caninum SRS2 Protein: Essential Vaccination Targets and Biochemical Features for Next-Generation Vaccine Design" @default.
- W4225971917 cites W1131968228 @default.
- W4225971917 cites W1570643690 @default.
- W4225971917 cites W1973107417 @default.
- W4225971917 cites W1978760648 @default.
- W4225971917 cites W1986191025 @default.
- W4225971917 cites W1992192767 @default.
- W4225971917 cites W1994958449 @default.
- W4225971917 cites W1998917415 @default.
- W4225971917 cites W2009588744 @default.
- W4225971917 cites W2012816847 @default.
- W4225971917 cites W2014495976 @default.
- W4225971917 cites W2015176909 @default.
- W4225971917 cites W2019498470 @default.
- W4225971917 cites W2022045788 @default.
- W4225971917 cites W2023667982 @default.
- W4225971917 cites W2025234785 @default.
- W4225971917 cites W2026485126 @default.
- W4225971917 cites W2031377053 @default.
- W4225971917 cites W2035014358 @default.
- W4225971917 cites W2037117861 @default.
- W4225971917 cites W2039135956 @default.
- W4225971917 cites W2041484272 @default.
- W4225971917 cites W2042650329 @default.
- W4225971917 cites W2047994201 @default.
- W4225971917 cites W2049404292 @default.
- W4225971917 cites W2051881983 @default.
- W4225971917 cites W2061182704 @default.
- W4225971917 cites W2066607062 @default.
- W4225971917 cites W2073958510 @default.
- W4225971917 cites W2080081312 @default.
- W4225971917 cites W2088859893 @default.
- W4225971917 cites W2095240344 @default.
- W4225971917 cites W2097874743 @default.
- W4225971917 cites W2098859487 @default.
- W4225971917 cites W2099606443 @default.
- W4225971917 cites W2099770099 @default.
- W4225971917 cites W2100577789 @default.
- W4225971917 cites W2102367710 @default.
- W4225971917 cites W2102993309 @default.
- W4225971917 cites W2104629795 @default.
- W4225971917 cites W2107141790 @default.
- W4225971917 cites W2110298304 @default.
- W4225971917 cites W2114671362 @default.
- W4225971917 cites W2130887658 @default.
- W4225971917 cites W2131321191 @default.
- W4225971917 cites W2136038481 @default.
- W4225971917 cites W2142529984 @default.
- W4225971917 cites W2149525061 @default.
- W4225971917 cites W2149545014 @default.
- W4225971917 cites W2151932306 @default.
- W4225971917 cites W2154267586 @default.
- W4225971917 cites W2156430664 @default.
- W4225971917 cites W2166029068 @default.
- W4225971917 cites W2171295581 @default.
- W4225971917 cites W2174245779 @default.
- W4225971917 cites W2409348646 @default.
- W4225971917 cites W2412997666 @default.
- W4225971917 cites W2620185010 @default.
- W4225971917 cites W2752092848 @default.
- W4225971917 cites W2796509398 @default.
- W4225971917 cites W2799758313 @default.
- W4225971917 cites W2898159424 @default.
- W4225971917 cites W2944387521 @default.
- W4225971917 cites W3029489239 @default.
- W4225971917 cites W3036711000 @default.
- W4225971917 cites W3042206999 @default.
- W4225971917 cites W3086829363 @default.
- W4225971917 cites W3092171256 @default.
- W4225971917 cites W3094164779 @default.
- W4225971917 cites W3095718819 @default.
- W4225971917 cites W3119507463 @default.
- W4225971917 cites W3131300559 @default.
- W4225971917 cites W3132449324 @default.
- W4225971917 cites W3166053245 @default.
- W4225971917 cites W3173438266 @default.
- W4225971917 cites W3189270311 @default.
- W4225971917 cites W4244736178 @default.
- W4225971917 cites W4365787718 @default.
- W4225971917 doi "https://doi.org/10.1155/2022/7070144" @default.
- W4225971917 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35434127" @default.
- W4225971917 hasPublicationYear "2022" @default.
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