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• W4225971931 abstract "The generation of breast implant-associated anaplastic large-cell lymphoma (BIA-ALCL) is closely associated with textured implants. The phenotype of BIA-ALCL cells is well examined, but its cell of origin remains unknown. Here we investigate what types of T cells are recruited and differentiated in the surrounding capsules and tissues as a consequence of continuous contact with a textured surface.Capsule and pericapsule tissues were recovered from patients who had textured or smooth tissue expanders (TEs). These samples were enzymatically digested, and T cells in the samples were analyzed using flow cytometry. Peripheral blood mononuclear cells from the same donors were utilized as a control.Effector memory CD4+ T cells predominantly infiltrated capsules and tissues without apparent differences between textured and smooth TEs. In these effector memory CD4+ T cells, CD4+ resident memory T cells were generated by smooth TEs but not by textured TEs. However, TNFRSF8/CD30 mRNA expression is higher in the CD69- effector memory CD4+ T cells than in the CD69+ ones.Textured and smooth TEs differentially recruit and/or differentiate T cells in situ." @default.
• W4225971931 created "2022-05-05" @default.
• W4225971931 creator A5003712746 @default.
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• W4225971931 date "2022-03-01" @default.
• W4225971931 modified "2023-09-25" @default.
• W4225971931 title "Tissue Expander–associated T Cells: Relevance to Breast Implant–associated Anaplastic Large-cell Lymphoma" @default.
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• W4225971931 doi "https://doi.org/10.1097/gox.0000000000004148" @default.
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