FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4225978082> ?p ?o ?g. }

• W4225978082 endingPage "9686" @default.
• W4225978082 startingPage "9669" @default.
• W4225978082 abstract "In temporal lobe epilepsy, the ability of the dentate gyrus to limit excitatory cortical input to the hippocampus breaks down, leading to seizures. The dentate gyrus is also thought to help discriminate between similar memories by performing pattern separation, but whether epilepsy leads to a breakdown in this neural computation, and thus to mnemonic discrimination impairments, remains unknown. Here we show that temporal lobe epilepsy is characterized by behavioral deficits in mnemonic discrimination tasks, in both humans (females and males) and mice (C57Bl6 males, systemic low-dose kainate model). Using a recently developed assay in brain slices of the same epileptic mice, we reveal a decreased ability of the dentate gyrus to perform certain forms of pattern separation. This is because of a subset of granule cells with abnormal bursting that can develop independently of early EEG abnormalities. Overall, our results linking physiology, computation, and cognition in the same mice advance our understanding of episodic memory mechanisms and their dysfunction in epilepsy. SIGNIFICANCE STATEMENT People with temporal lobe epilepsy (TLE) often have learning and memory impairments, sometimes occurring earlier than the first seizure, but those symptoms and their biological underpinnings are poorly understood. We focused on the dentate gyrus, a brain region that is critical to avoid confusion between similar memories and is anatomically disorganized in TLE. We show that both humans and mice with TLE experience confusion between similar situations. This impairment coincides with a failure of the dentate gyrus to disambiguate similar input signals because of pathologic bursting in a subset of neurons. Our work bridges seizure-oriented and memory-oriented views of the dentate gyrus function, suggests a mechanism for cognitive symptoms in TLE, and supports a long-standing hypothesis of episodic memory theories." @default.
• W4225978082 created "2022-05-05" @default.
• W4225978082 creator A5008511575 @default.
• W4225978082 creator A5011757473 @default.
• W4225978082 creator A5012107182 @default.
• W4225978082 creator A5020454494 @default.
• W4225978082 creator A5045674963 @default.
• W4225978082 creator A5047492092 @default.
• W4225978082 creator A5057607744 @default.
• W4225978082 creator A5058329383 @default.
• W4225978082 creator A5088029540 @default.
• W4225978082 creator A5091245832 @default.
• W4225978082 date "2021-10-07" @default.
• W4225978082 modified "2023-10-17" @default.
• W4225978082 title "Deficits in Behavioral and Neuronal Pattern Separation in Temporal Lobe Epilepsy" @default.
• W4225978082 cites W1497432777 @default.
• W4225978082 cites W1504817278 @default.
• W4225978082 cites W1563004431 @default.
• W4225978082 cites W1589666289 @default.
• W4225978082 cites W1843158289 @default.
• W4225978082 cites W1860061297 @default.
• W4225978082 cites W1887565531 @default.
• W4225978082 cites W1906116459 @default.
• W4225978082 cites W1926193477 @default.
• W4225978082 cites W1965558640 @default.
• W4225978082 cites W1966474984 @default.
• W4225978082 cites W1966903916 @default.
• W4225978082 cites W1974289805 @default.
• W4225978082 cites W1975730562 @default.
• W4225978082 cites W1976714189 @default.
• W4225978082 cites W1980006923 @default.
• W4225978082 cites W1983628429 @default.
• W4225978082 cites W1990701202 @default.
• W4225978082 cites W1996118086 @default.
• W4225978082 cites W1997094114 @default.
• W4225978082 cites W2004017387 @default.
• W4225978082 cites W2012123457 @default.
• W4225978082 cites W2012667903 @default.
• W4225978082 cites W2014460069 @default.
• W4225978082 cites W2017055595 @default.
• W4225978082 cites W2022036472 @default.
• W4225978082 cites W2022686017 @default.
• W4225978082 cites W2028346421 @default.
• W4225978082 cites W2028635505 @default.
• W4225978082 cites W2029158661 @default.
• W4225978082 cites W2029598577 @default.
• W4225978082 cites W2033119928 @default.
• W4225978082 cites W2040652269 @default.
• W4225978082 cites W2040821610 @default.
• W4225978082 cites W2050386667 @default.
• W4225978082 cites W2055292598 @default.
• W4225978082 cites W2056992784 @default.
• W4225978082 cites W2057230367 @default.
• W4225978082 cites W2061446261 @default.
• W4225978082 cites W2063268783 @default.
• W4225978082 cites W2065337015 @default.
• W4225978082 cites W2072956069 @default.
• W4225978082 cites W2079239821 @default.
• W4225978082 cites W2082977820 @default.
• W4225978082 cites W2083201910 @default.
• W4225978082 cites W2085534172 @default.
• W4225978082 cites W2092284040 @default.
• W4225978082 cites W2096131894 @default.
• W4225978082 cites W2099751838 @default.
• W4225978082 cites W2103946141 @default.
• W4225978082 cites W2107165322 @default.
• W4225978082 cites W2111273472 @default.
• W4225978082 cites W2114093008 @default.
• W4225978082 cites W2115725934 @default.
• W4225978082 cites W2116464190 @default.
• W4225978082 cites W2119060662 @default.
• W4225978082 cites W2120629471 @default.
• W4225978082 cites W2122817080 @default.
• W4225978082 cites W2130044487 @default.
• W4225978082 cites W2152826846 @default.
• W4225978082 cites W2154731415 @default.
• W4225978082 cites W2167912320 @default.
• W4225978082 cites W2170972933 @default.
• W4225978082 cites W2207460105 @default.
• W4225978082 cites W2224362382 @default.
• W4225978082 cites W2225062018 @default.
• W4225978082 cites W2311241788 @default.
• W4225978082 cites W2338776442 @default.
• W4225978082 cites W2374315242 @default.
• W4225978082 cites W2416102887 @default.
• W4225978082 cites W2489879568 @default.
• W4225978082 cites W2502569473 @default.
• W4225978082 cites W2522618573 @default.
• W4225978082 cites W2548312700 @default.
• W4225978082 cites W2549468863 @default.
• W4225978082 cites W2554057527 @default.
• W4225978082 cites W2589649940 @default.
• W4225978082 cites W2596916613 @default.
• W4225978082 cites W2601952071 @default.
• W4225978082 cites W2618155558 @default.
• W4225978082 cites W2766932545 @default.
• W4225978082 cites W2787829706 @default.
• W4225978082 cites W2791770438 @default.

• next