FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4225987224> ?p ?o ?g. }

• W4225987224 abstract "Beyond the CNS, urotensin II (UII) and its receptor (UT) are functionally expressed in peripheral tissues of the endocrine, cardiovascular, and renal systems. The expression levels of UII and UT in the kidney and circulating UII levels are increased in diabetes. UII also promotes mesangial proliferation and matrix accumulation in vitro. Here, we evaluate the effect of UT deletion on the development of hyperglycemia and diabetic kidney disease (DKD) in streptozotocin (STZ)-treated mice. Ten-week-old WT and UT knockout (KO) mice were injected with STZ for 5 days to induce diabetes. Blood glucose levels were measured weekly, and necropsy was performed 12 weeks after STZ injection. UT ablation slowed hyperglycemia and glucosuria in STZ-treated mice. UT KO also ameliorated STZ-induced increase in HbA1c, but not STZ-induced decrease in plasma insulin levels. However, STZ-induced increases in plasma glucagon concentration and immunohistochemical staining for glucagon in pancreatic islets were lessened in UT KO mice. UT ablation also protected against STZ-induced kidney derangements, including albuminuria, mesangial expansion, glomerular lesions, and glomerular endoplasmic reticulum stress. UT is expressed in a cultured pancreatic alpha cell line, and its activation by UII triggered membrane depolarization, T- and L-type voltage-gated Ca2+channel-dependent Ca2+influx, and glucagon secretion. These findings suggest that apart from direct action on the kidneys to cause injury, UT activation by UII may result in DKD by promoting hyperglycemia via induction of glucagon secretion by pancreatic alpha cells." @default.
• W4225987224 created "2022-05-05" @default.
• W4225987224 creator A5011822238 @default.
• W4225987224 creator A5013795544 @default.
• W4225987224 creator A5016851807 @default.
• W4225987224 creator A5085082885 @default.
• W4225987224 creator A5089800747 @default.
• W4225987224 date "2022-03-01" @default.
• W4225987224 modified "2023-10-17" @default.
• W4225987224 title "Loss of urotensin II receptor diminishes hyperglycemia and kidney injury in streptozotocin-treated mice" @default.
• W4225987224 cites W1928609751 @default.
• W4225987224 cites W1948191990 @default.
• W4225987224 cites W1985158294 @default.
• W4225987224 cites W1988801692 @default.
• W4225987224 cites W1990334947 @default.
• W4225987224 cites W1997034695 @default.
• W4225987224 cites W2015811602 @default.
• W4225987224 cites W2020075835 @default.
• W4225987224 cites W2025993954 @default.
• W4225987224 cites W2061643046 @default.
• W4225987224 cites W2063808488 @default.
• W4225987224 cites W2064720673 @default.
• W4225987224 cites W2074745209 @default.
• W4225987224 cites W2075105305 @default.
• W4225987224 cites W2082277504 @default.
• W4225987224 cites W2089125273 @default.
• W4225987224 cites W2090307119 @default.
• W4225987224 cites W2096396734 @default.
• W4225987224 cites W2098957321 @default.
• W4225987224 cites W2099540750 @default.
• W4225987224 cites W2101814428 @default.
• W4225987224 cites W2104208024 @default.
• W4225987224 cites W2106259414 @default.
• W4225987224 cites W2107614347 @default.
• W4225987224 cites W2130335200 @default.
• W4225987224 cites W2145363840 @default.
• W4225987224 cites W2145833822 @default.
• W4225987224 cites W2147582807 @default.
• W4225987224 cites W2147618512 @default.
• W4225987224 cites W2152578678 @default.
• W4225987224 cites W2153961098 @default.
• W4225987224 cites W2155292938 @default.
• W4225987224 cites W2157815513 @default.
• W4225987224 cites W2159765899 @default.
• W4225987224 cites W2159937109 @default.
• W4225987224 cites W2163595098 @default.
• W4225987224 cites W2188217851 @default.
• W4225987224 cites W2201833170 @default.
• W4225987224 cites W2464700450 @default.
• W4225987224 cites W2469239379 @default.
• W4225987224 cites W2778009653 @default.
• W4225987224 cites W2923328801 @default.
• W4225987224 cites W3027273835 @default.
• W4225987224 cites W3124710790 @default.
• W4225987224 doi "https://doi.org/10.1530/jme-21-0199" @default.
• W4225987224 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35244607" @default.
• W4225987224 hasPublicationYear "2022" @default.
• W4225987224 type Work @default.
• W4225987224 citedByCount "0" @default.
• W4225987224 crossrefType "journal-article" @default.
• W4225987224 hasAuthorship W4225987224A5011822238 @default.
• W4225987224 hasAuthorship W4225987224A5013795544 @default.
• W4225987224 hasAuthorship W4225987224A5016851807 @default.
• W4225987224 hasAuthorship W4225987224A5085082885 @default.
• W4225987224 hasAuthorship W4225987224A5089800747 @default.
• W4225987224 hasBestOaLocation W42259872241 @default.
• W4225987224 hasConcept C126322002 @default.
• W4225987224 hasConcept C134018914 @default.
• W4225987224 hasConcept C170493617 @default.
• W4225987224 hasConcept C185592680 @default.
• W4225987224 hasConcept C2778563252 @default.
• W4225987224 hasConcept C2779280383 @default.
• W4225987224 hasConcept C2779306644 @default.
• W4225987224 hasConcept C2779922275 @default.
• W4225987224 hasConcept C2779935178 @default.
• W4225987224 hasConcept C2780091579 @default.
• W4225987224 hasConcept C555293320 @default.
• W4225987224 hasConcept C71924100 @default.
• W4225987224 hasConceptScore W4225987224C126322002 @default.
• W4225987224 hasConceptScore W4225987224C134018914 @default.
• W4225987224 hasConceptScore W4225987224C170493617 @default.
• W4225987224 hasConceptScore W4225987224C185592680 @default.
• W4225987224 hasConceptScore W4225987224C2778563252 @default.
• W4225987224 hasConceptScore W4225987224C2779280383 @default.
• W4225987224 hasConceptScore W4225987224C2779306644 @default.
• W4225987224 hasConceptScore W4225987224C2779922275 @default.
• W4225987224 hasConceptScore W4225987224C2779935178 @default.
• W4225987224 hasConceptScore W4225987224C2780091579 @default.
• W4225987224 hasConceptScore W4225987224C555293320 @default.
• W4225987224 hasConceptScore W4225987224C71924100 @default.
• W4225987224 hasLocation W42259872241 @default.
• W4225987224 hasLocation W42259872242 @default.
• W4225987224 hasLocation W42259872243 @default.
• W4225987224 hasOpenAccess W4225987224 @default.
• W4225987224 hasPrimaryLocation W42259872241 @default.
• W4225987224 hasRelatedWork W1855195526 @default.
• W4225987224 hasRelatedWork W2002695797 @default.
• W4225987224 hasRelatedWork W2004012005 @default.
• W4225987224 hasRelatedWork W2028699422 @default.
• W4225987224 hasRelatedWork W2042839462 @default.

• next