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- W4225993886 abstract "Abstract Eukaryotic genomes are pervasively transcribed by RNA polymerase II (RNAPII), and transcription of long non-coding RNAs often overlaps with coding gene promoters. This might lead to coding gene repression in a process named Transcription Interference (TI). In Saccharomyces cerevisiae, TI is mainly driven by antisense non-coding transcription and occurs through re-shaping of promoter Nucleosome-Depleted Regions (NDRs). In this study, we developed a genetic screen to identify new players involved in Antisense-Mediated Transcription Interference (AMTI). Among the candidates, we found the HIR histone chaperone complex known to be involved in de novo histone deposition. Using genome-wide approaches, we reveal that HIR-dependent histone deposition represses the promoters of SAGA-dependent genes via antisense non-coding transcription. However, while antisense transcription is enriched at promoters of SAGA-dependent genes, this feature is not sufficient to define the mode of gene regulation. We further show that the balance between HIR-dependent nucleosome incorporation and transcription factor binding at promoters directs transcription into a SAGA- or TFIID-dependent regulation. This study sheds light on a new connection between antisense non-coding transcription and the nature of coding transcription initiation." @default.
- W4225993886 created "2022-05-05" @default.
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- W4225993886 date "2022-04-26" @default.
- W4225993886 modified "2023-10-11" @default.
- W4225993886 title "Antisense-mediated repression of SAGA-dependent genes involves the HIR histone chaperone" @default.
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- W4225993886 doi "https://doi.org/10.1093/nar/gkac264" @default.
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- W4225993886 hasPublicationYear "2022" @default.
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