Matches in SemOpenAlex for { <https://semopenalex.org/work/W4226012912> ?p ?o ?g. }
- W4226012912 abstract "During ontogeny, macrophage populations emerge in the Yolk Sac (YS) via two distinct progenitor waves, prior to hematopoietic stem cell development. Macrophage progenitors from the primitive/early EMP and transient-definitive/late EMP waves both contribute to various resident primitive macrophage populations in the developing embryonic organs. Identifying factors that modulates early stages of macrophage progenitor development may lead to a better understanding of defective function of specific resident macrophage subsets. Here we show that YS primitive macrophage progenitors express Lyl-1, a bHLH transcription factor related to SCL/Tal-1. Transcriptomic analysis of YS macrophage progenitors indicate that primitive macrophage progenitors present at embryonic day 9 are clearly distinct from those present at later stages. Disruption of Lyl-1 basic helix-loop-helix domain leads initially to an increased emergence of primitive macrophage progenitors, and later to their defective differentiation. These defects are associated with a disrupted expression of gene sets related to embryonic patterning and neurodevelopment. Lyl-1-deficiency also induce a reduced production of mature macrophages/microglia in the early brain, as well as a transient reduction of the microglia pool at midgestation and in the newborn. We thus identify Lyl-1 as a critical regulator of primitive macrophages and microglia development, which disruption may impair resident-macrophage function during organogenesis." @default.
- W4226012912 created "2022-05-05" @default.
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- W4226012912 date "2021-12-09" @default.
- W4226012912 modified "2023-10-16" @default.
- W4226012912 title "Lyl-1 regulates primitive macrophages and microglia development" @default.
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- W4226012912 doi "https://doi.org/10.1038/s42003-021-02886-5" @default.
- W4226012912 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34887504" @default.
- W4226012912 hasPublicationYear "2021" @default.
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