Matches in SemOpenAlex for { <https://semopenalex.org/work/W4226017138> ?p ?o ?g. }
- W4226017138 endingPage "301" @default.
- W4226017138 startingPage "287" @default.
- W4226017138 abstract "Myelination by oligodendrocytes is crucial for neuronal survival and function, and defects in myelination or failure in myelin repair can lead to axonal degeneration and various neurological diseases. At present, the factors that promote myelination and overcome the remyelination block in demyelinating diseases are poorly defined. Although the roles of protein-coding genes in oligodendrocyte differentiation have been extensively studied, the majority of the mammalian genome is transcribed into noncoding RNAs, and the functions of these molecules in myelination are poorly characterized. Long noncoding RNAs (lncRNAs) regulate transcription at multiple levels, providing spatiotemporal control and robustness for cell type-specific gene expression and physiological functions. lncRNAs have been shown to regulate neural cell-type specification, differentiation, and maintenance of cell identity, and dysregulation of lncRNA function has been shown to contribute to neurological diseases. In this review, we discuss recent advances in our understanding of the functions of lncRNAs in oligodendrocyte development and myelination as well their roles in neurological diseases and brain tumorigenesis. A more systematic characterization of lncRNA functional networks will be instrumental for a better understanding of CNS myelination, myelin disorders, and myelin repair." @default.
- W4226017138 created "2022-05-05" @default.
- W4226017138 creator A5012842010 @default.
- W4226017138 creator A5014243012 @default.
- W4226017138 creator A5017947172 @default.
- W4226017138 creator A5028380647 @default.
- W4226017138 creator A5051212623 @default.
- W4226017138 creator A5090341582 @default.
- W4226017138 date "2022-04-03" @default.
- W4226017138 modified "2023-09-23" @default.
- W4226017138 title "Long Noncoding RNAs in CNS Myelination and Disease" @default.
- W4226017138 cites W1575907081 @default.
- W4226017138 cites W1649032905 @default.
- W4226017138 cites W1835026554 @default.
- W4226017138 cites W1879996757 @default.
- W4226017138 cites W1938046568 @default.
- W4226017138 cites W1966880041 @default.
- W4226017138 cites W1973854653 @default.
- W4226017138 cites W1976383834 @default.
- W4226017138 cites W1979283544 @default.
- W4226017138 cites W1985286185 @default.
- W4226017138 cites W1989453114 @default.
- W4226017138 cites W1992605446 @default.
- W4226017138 cites W2003553455 @default.
- W4226017138 cites W2003924215 @default.
- W4226017138 cites W2007812767 @default.
- W4226017138 cites W2010231497 @default.
- W4226017138 cites W2011145849 @default.
- W4226017138 cites W2011598785 @default.
- W4226017138 cites W2015845481 @default.
- W4226017138 cites W2016928754 @default.
- W4226017138 cites W2021038808 @default.
- W4226017138 cites W2021548599 @default.
- W4226017138 cites W2029173942 @default.
- W4226017138 cites W2030658020 @default.
- W4226017138 cites W2032183472 @default.
- W4226017138 cites W2033094967 @default.
- W4226017138 cites W2038838851 @default.
- W4226017138 cites W2039262205 @default.
- W4226017138 cites W2046387002 @default.
- W4226017138 cites W2050794883 @default.
- W4226017138 cites W2051282896 @default.
- W4226017138 cites W2052902484 @default.
- W4226017138 cites W2054275187 @default.
- W4226017138 cites W2064835029 @default.
- W4226017138 cites W2071512787 @default.
- W4226017138 cites W2079588819 @default.
- W4226017138 cites W2084170466 @default.
- W4226017138 cites W2084194517 @default.
- W4226017138 cites W2085359313 @default.
- W4226017138 cites W2088748522 @default.
- W4226017138 cites W2091161969 @default.
- W4226017138 cites W2091204895 @default.
- W4226017138 cites W2098503291 @default.
- W4226017138 cites W2103015533 @default.
- W4226017138 cites W2105349784 @default.
- W4226017138 cites W2105479667 @default.
- W4226017138 cites W2111688179 @default.
- W4226017138 cites W2112282280 @default.
- W4226017138 cites W2113286169 @default.
- W4226017138 cites W2117719082 @default.
- W4226017138 cites W2121646982 @default.
- W4226017138 cites W2124940469 @default.
- W4226017138 cites W2125920059 @default.
- W4226017138 cites W2127154740 @default.
- W4226017138 cites W2128464557 @default.
- W4226017138 cites W2130313087 @default.
- W4226017138 cites W2131306683 @default.
- W4226017138 cites W2133437679 @default.
- W4226017138 cites W2134476703 @default.
- W4226017138 cites W2137782572 @default.
- W4226017138 cites W2138884188 @default.
- W4226017138 cites W2145931730 @default.
- W4226017138 cites W2147061679 @default.
- W4226017138 cites W2151341331 @default.
- W4226017138 cites W2166810745 @default.
- W4226017138 cites W2170804629 @default.
- W4226017138 cites W2172062863 @default.
- W4226017138 cites W2184997675 @default.
- W4226017138 cites W2198153867 @default.
- W4226017138 cites W2199550613 @default.
- W4226017138 cites W2204082443 @default.
- W4226017138 cites W2207064026 @default.
- W4226017138 cites W2234093367 @default.
- W4226017138 cites W2257936017 @default.
- W4226017138 cites W2288968461 @default.
- W4226017138 cites W2311921258 @default.
- W4226017138 cites W2313421525 @default.
- W4226017138 cites W2465240885 @default.
- W4226017138 cites W2510075458 @default.
- W4226017138 cites W2540143287 @default.
- W4226017138 cites W2549644306 @default.
- W4226017138 cites W2560385907 @default.
- W4226017138 cites W2565212965 @default.
- W4226017138 cites W2567665210 @default.
- W4226017138 cites W2575401126 @default.
- W4226017138 cites W2588834106 @default.
- W4226017138 cites W2589984951 @default.