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• W4226025919 startingPage "603" @default.
• W4226025919 abstract "Ovarian cancer is the leading cause of mortality due to gynecologic malignancy. The majority of women diagnosed with the most common subtype, high-grade serous ovarian carcinoma (HGSC), develop resistance to conventional therapies despite initial response to treatment. HGSC tumors displaying DNA damage repair (DDR) gene deficiency and high chromosomal instability mainly associate with higher cytotoxic immune cell infiltration and expression of genes associated with these immune pathways. Despite the high level of immune infiltration observed, the majority of patients with HGSC have not benefited from immunomodulatory treatments as the mechanistic basis of this infiltration is unclear. This lack of response can be primarily attributed to heterogeneity at the levels of both cancer cell genetic alterations and the tumour immune microenvironment. Strategies to enhance anti-tumour immunity have been investigated in ovarian cancer, of which interferon activating therapies present as an attractive option. Of the several type I interferon (IFN-1) stimulating therapies, exogenously activating the cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) pathway is emerging as a promising avenue. Herein, we highlight our current understanding of how constitutive and induced cGAS-STING pathway activation influences the ovarian tumour microenvironment. We further elaborate on the links between the genomic alterations prevalent in ovarian tumours and how the resultant immune phenotypes can make them more susceptible to exogenous STING pathway activation and potentiate immune-mediated killing of cancer cells. The therapeutic potential of cGAS-STING pathway activation in ovarian cancer and factors implicating treatment outcomes are discussed, providing a rationale for future combinatorial treatment approaches on the backbone of chemotherapy." @default.
• W4226025919 created "2022-05-05" @default.
• W4226025919 creator A5005468871 @default.
• W4226025919 creator A5006796069 @default.
• W4226025919 creator A5008428956 @default.
• W4226025919 creator A5055456849 @default.
• W4226025919 creator A5088578448 @default.
• W4226025919 date "2022-04-05" @default.
• W4226025919 modified "2023-10-14" @default.
• W4226025919 title "The STING pathway: Therapeutic vulnerabilities in ovarian cancer" @default.
• W4226025919 cites W1781764024 @default.
• W4226025919 cites W1821140461 @default.
• W4226025919 cites W1971620413 @default.
• W4226025919 cites W1994826332 @default.
• W4226025919 cites W2000177767 @default.
• W4226025919 cites W2012855647 @default.
• W4226025919 cites W2019888542 @default.
• W4226025919 cites W2027163190 @default.
• W4226025919 cites W2047958526 @default.
• W4226025919 cites W2060004514 @default.
• W4226025919 cites W2066797185 @default.
• W4226025919 cites W2097750604 @default.
• W4226025919 cites W2099610218 @default.
• W4226025919 cites W2111900617 @default.
• W4226025919 cites W2121982897 @default.
• W4226025919 cites W2132413371 @default.
• W4226025919 cites W2135660738 @default.
• W4226025919 cites W2137074525 @default.
• W4226025919 cites W2154171253 @default.
• W4226025919 cites W2164629825 @default.
• W4226025919 cites W2166937531 @default.
• W4226025919 cites W2176629342 @default.
• W4226025919 cites W2220279767 @default.
• W4226025919 cites W2438866487 @default.
• W4226025919 cites W2502288506 @default.
• W4226025919 cites W2515679040 @default.
• W4226025919 cites W2527992063 @default.
• W4226025919 cites W2528536528 @default.
• W4226025919 cites W2552487040 @default.
• W4226025919 cites W2579136823 @default.
• W4226025919 cites W2579137335 @default.
• W4226025919 cites W2724690266 @default.
• W4226025919 cites W2748037493 @default.
• W4226025919 cites W2754482076 @default.
• W4226025919 cites W2765953690 @default.
• W4226025919 cites W2777932404 @default.
• W4226025919 cites W2783585287 @default.
• W4226025919 cites W2783667606 @default.
• W4226025919 cites W2794063791 @default.
• W4226025919 cites W2800654890 @default.
• W4226025919 cites W2802480234 @default.
• W4226025919 cites W2807979064 @default.
• W4226025919 cites W2884264032 @default.
• W4226025919 cites W2885708852 @default.
• W4226025919 cites W2889973703 @default.
• W4226025919 cites W2890875511 @default.
• W4226025919 cites W2897257669 @default.
• W4226025919 cites W2902038187 @default.
• W4226025919 cites W2902967495 @default.
• W4226025919 cites W2903718866 @default.
• W4226025919 cites W2906152084 @default.
• W4226025919 cites W2906160139 @default.
• W4226025919 cites W2912593436 @default.
• W4226025919 cites W2912593557 @default.
• W4226025919 cites W2919704769 @default.
• W4226025919 cites W2922049377 @default.
• W4226025919 cites W2948338608 @default.
• W4226025919 cites W2958040314 @default.
• W4226025919 cites W2961683572 @default.
• W4226025919 cites W2966261467 @default.
• W4226025919 cites W2966340800 @default.
• W4226025919 cites W2966710588 @default.
• W4226025919 cites W2972388126 @default.
• W4226025919 cites W2975141952 @default.
• W4226025919 cites W2980065541 @default.
• W4226025919 cites W2990742618 @default.
• W4226025919 cites W2993136094 @default.
• W4226025919 cites W2995171541 @default.
• W4226025919 cites W2998015544 @default.
• W4226025919 cites W2999745029 @default.
• W4226025919 cites W3000675092 @default.
• W4226025919 cites W3010197652 @default.
• W4226025919 cites W3022344729 @default.
• W4226025919 cites W3024191006 @default.
• W4226025919 cites W3031036292 @default.
• W4226025919 cites W3035115742 @default.
• W4226025919 cites W3038007966 @default.
• W4226025919 cites W3041933748 @default.
• W4226025919 cites W3043558366 @default.
• W4226025919 cites W3044997479 @default.
• W4226025919 cites W3047618013 @default.
• W4226025919 cites W3049241962 @default.
• W4226025919 cites W3101276404 @default.
• W4226025919 cites W3106005610 @default.
• W4226025919 cites W3111468108 @default.
• W4226025919 cites W3113156128 @default.
• W4226025919 cites W3113261035 @default.
• W4226025919 cites W3119259933 @default.

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