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- W4226034898 abstract "Gray zone lymphoma (GZL), a rare type of B-cell lymphoma (BCL), has features between diffuse large BCL and classical Hodgkin lymphoma (cHL) and an unfavorable outcome. The expression of PD-L1, encoded by chromosome 9p24.1, has been positively correlated with the copy number alteration of 9p24.1, and it has been associated with a high response rate to anti-PD-1 treatment in cHL and primary mediastinal large BCL (PMBCL). GZL shares similar genomic alterations with cHL and PMBCL, and thus, it may also respond well to anti-PD-1 treatment. However, little is known about the efficacy of anti-PD-1 treatment and the predictive role of PD-L1 expression in GZL. Here, we present a case of GZL refractory to first-line chemotherapy. The patient had a high expression of PD-L1 and was successfully treated with pembrolizumab as a salvage treatment, followed by autologous stem cell transplantation (ASCT) in January 2018. The patient still had a complete metabolic response 42 months after ASCT." @default.
- W4226034898 created "2022-05-05" @default.
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- W4226034898 date "2022-01-01" @default.
- W4226034898 modified "2023-09-23" @default.
- W4226034898 title "Pembrolizumab as a bridge to autologous stem cell transplantation in refractory gray zone lymphoma" @default.
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- W4226034898 doi "https://doi.org/10.4103/jcrp.jcrp_34_21" @default.
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