Matches in SemOpenAlex for { <https://semopenalex.org/work/W4226048230> ?p ?o ?g. }
- W4226048230 endingPage "262" @default.
- W4226048230 startingPage "262" @default.
- W4226048230 abstract "Background: Component compatibility is important to the modernization of traditional Chinese medicine. Studies have shown that San-ao decoction (SAD) can treat respiratory diseases by relaxing airway smooth muscle (ASM) and reducing airway hyper-responsiveness. However, whether its bioactive components and compatibility also present with similar relaxant effects remains unknown. This study aims to explore the potential relaxant property, dose-response relationship, and underlying mechanisms of the bioactive component compatibility in SAD. Methods: Network pharmacology was primarily used to identify the bioactive components of SAD and uncover its underlying mechanisms. ASM tension force measuring technique was utilized to verify the relaxant and dose-response effects on in vitro guinea pig ASM. Results: We postulated pseudoephedrine hydrochloride (PH), amygdalin (AM), and diammonium glycyrrhizate (DG) to be the bioactive components of SAD, which could effectively relax ASM in a dose-dependent manner on both acetylcholine-induced and spontaneous contraction. Both PH and AM could lead to DG dose–response curve shift. The regression equation of these three bioactive components was Y = −2.048 × X1 + 0.411 × X2 + 14.052 × X3 (X1, X2, X3 representing PH, AM, and DG, respectively). The underlying mechanisms of these components might be associated with the regulation of smooth muscle contraction. Conclusions: PH, AM, and DG are the bioactive components of SAD, which can relax ASM in a dose–response manner and exert a synergistic effect. Clinically, compatibility of these three bioactive components may serve as a new complementary and alternative treatment for respiratory diseases." @default.
- W4226048230 created "2022-05-05" @default.
- W4226048230 creator A5005818962 @default.
- W4226048230 creator A5021749487 @default.
- W4226048230 creator A5025241054 @default.
- W4226048230 creator A5033017179 @default.
- W4226048230 creator A5044359398 @default.
- W4226048230 creator A5074959373 @default.
- W4226048230 date "2022-01-01" @default.
- W4226048230 modified "2023-09-26" @default.
- W4226048230 title "Relaxant effect of bioactive component compatibility of <i>San-ao</i> decoction on <i>In vitro</i> guinea pig airway smooth muscle: A dose–response relationship study" @default.
- W4226048230 cites W1964819675 @default.
- W4226048230 cites W1970535845 @default.
- W4226048230 cites W1977709595 @default.
- W4226048230 cites W1994033752 @default.
- W4226048230 cites W2001953426 @default.
- W4226048230 cites W2007276837 @default.
- W4226048230 cites W2009563915 @default.
- W4226048230 cites W2009818284 @default.
- W4226048230 cites W2011174956 @default.
- W4226048230 cites W2021471527 @default.
- W4226048230 cites W2030864148 @default.
- W4226048230 cites W2044002635 @default.
- W4226048230 cites W2053995911 @default.
- W4226048230 cites W2076804940 @default.
- W4226048230 cites W2078077815 @default.
- W4226048230 cites W2099853664 @default.
- W4226048230 cites W2195424142 @default.
- W4226048230 cites W2198491272 @default.
- W4226048230 cites W2233753101 @default.
- W4226048230 cites W2333437914 @default.
- W4226048230 cites W2365138737 @default.
- W4226048230 cites W2404266754 @default.
- W4226048230 cites W2480521561 @default.
- W4226048230 cites W2531469489 @default.
- W4226048230 cites W2572514692 @default.
- W4226048230 cites W2573767349 @default.
- W4226048230 cites W2583265473 @default.
- W4226048230 cites W2601988452 @default.
- W4226048230 cites W2604775613 @default.
- W4226048230 cites W2610346184 @default.
- W4226048230 cites W2610984247 @default.
- W4226048230 cites W2613136430 @default.
- W4226048230 cites W2744030183 @default.
- W4226048230 cites W2765490090 @default.
- W4226048230 cites W2766511493 @default.
- W4226048230 cites W2767152425 @default.
- W4226048230 cites W2773188848 @default.
- W4226048230 cites W2789594745 @default.
- W4226048230 cites W2791925623 @default.
- W4226048230 cites W2792034293 @default.
- W4226048230 cites W2913147596 @default.
- W4226048230 doi "https://doi.org/10.4103/wjtcm.wjtcm_64_21" @default.
- W4226048230 hasPublicationYear "2022" @default.
- W4226048230 type Work @default.
- W4226048230 citedByCount "1" @default.
- W4226048230 countsByYear W42260482302022 @default.
- W4226048230 crossrefType "journal-article" @default.
- W4226048230 hasAuthorship W4226048230A5005818962 @default.
- W4226048230 hasAuthorship W4226048230A5021749487 @default.
- W4226048230 hasAuthorship W4226048230A5025241054 @default.
- W4226048230 hasAuthorship W4226048230A5033017179 @default.
- W4226048230 hasAuthorship W4226048230A5044359398 @default.
- W4226048230 hasAuthorship W4226048230A5074959373 @default.
- W4226048230 hasBestOaLocation W42260482301 @default.
- W4226048230 hasConcept C126322002 @default.
- W4226048230 hasConcept C163415756 @default.
- W4226048230 hasConcept C185592680 @default.
- W4226048230 hasConcept C190409667 @default.
- W4226048230 hasConcept C202751555 @default.
- W4226048230 hasConcept C2775910092 @default.
- W4226048230 hasConcept C2778815084 @default.
- W4226048230 hasConcept C55493867 @default.
- W4226048230 hasConcept C556039675 @default.
- W4226048230 hasConcept C71924100 @default.
- W4226048230 hasConcept C98274493 @default.
- W4226048230 hasConceptScore W4226048230C126322002 @default.
- W4226048230 hasConceptScore W4226048230C163415756 @default.
- W4226048230 hasConceptScore W4226048230C185592680 @default.
- W4226048230 hasConceptScore W4226048230C190409667 @default.
- W4226048230 hasConceptScore W4226048230C202751555 @default.
- W4226048230 hasConceptScore W4226048230C2775910092 @default.
- W4226048230 hasConceptScore W4226048230C2778815084 @default.
- W4226048230 hasConceptScore W4226048230C55493867 @default.
- W4226048230 hasConceptScore W4226048230C556039675 @default.
- W4226048230 hasConceptScore W4226048230C71924100 @default.
- W4226048230 hasConceptScore W4226048230C98274493 @default.
- W4226048230 hasIssue "2" @default.
- W4226048230 hasLocation W42260482301 @default.
- W4226048230 hasOpenAccess W4226048230 @default.
- W4226048230 hasPrimaryLocation W42260482301 @default.
- W4226048230 hasRelatedWork W2044829717 @default.
- W4226048230 hasRelatedWork W2059530044 @default.
- W4226048230 hasRelatedWork W2355818271 @default.
- W4226048230 hasRelatedWork W2358369871 @default.
- W4226048230 hasRelatedWork W2372193143 @default.
- W4226048230 hasRelatedWork W2383228534 @default.
- W4226048230 hasRelatedWork W2389552009 @default.