FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4226051697> ?p ?o ?g. }

• W4226051697 abstract "Abstract Background The giant panda ( Ailuropoda melanoleuca ) is a well-known, rare and endangered species. Baylisascaris schroederi is a pathogenic ascarid. Infection with B. schroederi may cause death in giant pandas. At present, the immune evasion mechanism of B. schroederi is little known. Cysteine protease inhibitors (CPI) play important roles in the regulation of host immune responses against certain nematodes. In this study, we focused on the analysis of the regulation of B. schroederi migratory larvae CPI (rBsCPI-1) on mice immune cells. Methods First, the pattern recognition receptors on the surface of peripheral blood mononuclear cells (PBMCs) and the signal pathways that transduce extracellular signals into the nucleus activated by rBsCPI-1 were identified. Then, the regulatory effects of rBsCPI-1 on PBMCs physiological activities were detected. Finally, the effects of rBsCPI-1 on TLR signaling pathway activation and NF-κB phosphorylation in mice immunized with recombinant protein were analysed. Results The results suggested that rBsCPI-1 secreted by B. schroederi migratory larvae is mainly recognized by TLR2 and TLR4 on PBMCs. Extracellular signals are transduced into the nucleus through the MAPK and NF-κB signaling pathways, enhancing the phagocytosis, migration, and apoptosis of PBMCs; meanwhile, rBsCPI-1 induces high expression of NO. Thus, rBsCPI-1 plays a role in immune regulation. In addition, the high expression of negative regulatory factors also ensured that TLR activation is maintained at the optimal level. Conclusions rBsCPI-1 can transduce regulatory signals into immune cells by activating the TLR2/4-NF-κB/MAPK signaling pathway, having a certain regulatory effect on the physiological activities. Meanwhile, rBsCPI-1 can maintain the immune response in a balance by limiting the over-activation of the TLRs signaling pathway and thus contributes to B. schroederi immune evasion. Graphical Abstract" @default.
• W4226051697 created "2022-05-05" @default.
• W4226051697 creator A5012841823 @default.
• W4226051697 creator A5022047064 @default.
• W4226051697 creator A5031861925 @default.
• W4226051697 creator A5035778127 @default.
• W4226051697 creator A5040269731 @default.
• W4226051697 creator A5040822775 @default.
• W4226051697 creator A5086192777 @default.
• W4226051697 creator A5090346341 @default.
• W4226051697 date "2022-04-04" @default.
• W4226051697 modified "2023-09-25" @default.
• W4226051697 title "Regulatory effects of a novel cysteine protease inhibitor in Baylisascaris schroederi migratory larvae on mice immune cells" @default.
• W4226051697 cites W1547736903 @default.
• W4226051697 cites W1832818975 @default.
• W4226051697 cites W1876851871 @default.
• W4226051697 cites W1960809236 @default.
• W4226051697 cites W1984967104 @default.
• W4226051697 cites W1995744610 @default.
• W4226051697 cites W2011060686 @default.
• W4226051697 cites W2017895578 @default.
• W4226051697 cites W2028949865 @default.
• W4226051697 cites W2040321036 @default.
• W4226051697 cites W2041905742 @default.
• W4226051697 cites W2042433863 @default.
• W4226051697 cites W2052834898 @default.
• W4226051697 cites W2061570808 @default.
• W4226051697 cites W2077058436 @default.
• W4226051697 cites W2090750956 @default.
• W4226051697 cites W2135449563 @default.
• W4226051697 cites W2143321106 @default.
• W4226051697 cites W2149848093 @default.
• W4226051697 cites W2157590511 @default.
• W4226051697 cites W2168435069 @default.
• W4226051697 cites W2485004164 @default.
• W4226051697 cites W2568332637 @default.
• W4226051697 cites W2586779720 @default.
• W4226051697 cites W2595037158 @default.
• W4226051697 cites W2730604637 @default.
• W4226051697 cites W2735815555 @default.
• W4226051697 cites W2768522829 @default.
• W4226051697 cites W2789627713 @default.
• W4226051697 cites W2793300034 @default.
• W4226051697 cites W2909988704 @default.
• W4226051697 cites W2913951678 @default.
• W4226051697 cites W2951205651 @default.
• W4226051697 cites W2988614336 @default.
• W4226051697 cites W2999268672 @default.
• W4226051697 cites W3001505967 @default.
• W4226051697 cites W3006851158 @default.
• W4226051697 cites W3012283572 @default.
• W4226051697 cites W3013726226 @default.
• W4226051697 cites W3014538402 @default.
• W4226051697 cites W3014808794 @default.
• W4226051697 cites W3087064747 @default.
• W4226051697 cites W3092695514 @default.
• W4226051697 cites W3096924213 @default.
• W4226051697 cites W3197558150 @default.
• W4226051697 cites W4249383371 @default.
• W4226051697 cites W46604872 @default.
• W4226051697 doi "https://doi.org/10.1186/s13071-022-05240-8" @default.
• W4226051697 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35379304" @default.
• W4226051697 hasPublicationYear "2022" @default.
• W4226051697 type Work @default.
• W4226051697 citedByCount "1" @default.
• W4226051697 countsByYear W42260516972022 @default.
• W4226051697 crossrefType "journal-article" @default.
• W4226051697 hasAuthorship W4226051697A5012841823 @default.
• W4226051697 hasAuthorship W4226051697A5022047064 @default.
• W4226051697 hasAuthorship W4226051697A5031861925 @default.
• W4226051697 hasAuthorship W4226051697A5035778127 @default.
• W4226051697 hasAuthorship W4226051697A5040269731 @default.
• W4226051697 hasAuthorship W4226051697A5040822775 @default.
• W4226051697 hasAuthorship W4226051697A5086192777 @default.
• W4226051697 hasAuthorship W4226051697A5090346341 @default.
• W4226051697 hasBestOaLocation W42260516971 @default.
• W4226051697 hasConcept C181199279 @default.
• W4226051697 hasConcept C203014093 @default.
• W4226051697 hasConcept C2776070231 @default.
• W4226051697 hasConcept C2776714187 @default.
• W4226051697 hasConcept C2777283782 @default.
• W4226051697 hasConcept C2781236682 @default.
• W4226051697 hasConcept C55493867 @default.
• W4226051697 hasConcept C57074206 @default.
• W4226051697 hasConcept C62478195 @default.
• W4226051697 hasConcept C86803240 @default.
• W4226051697 hasConcept C8891405 @default.
• W4226051697 hasConcept C95444343 @default.
• W4226051697 hasConceptScore W4226051697C181199279 @default.
• W4226051697 hasConceptScore W4226051697C203014093 @default.
• W4226051697 hasConceptScore W4226051697C2776070231 @default.
• W4226051697 hasConceptScore W4226051697C2776714187 @default.
• W4226051697 hasConceptScore W4226051697C2777283782 @default.
• W4226051697 hasConceptScore W4226051697C2781236682 @default.
• W4226051697 hasConceptScore W4226051697C55493867 @default.
• W4226051697 hasConceptScore W4226051697C57074206 @default.
• W4226051697 hasConceptScore W4226051697C62478195 @default.
• W4226051697 hasConceptScore W4226051697C86803240 @default.
• W4226051697 hasConceptScore W4226051697C8891405 @default.
• W4226051697 hasConceptScore W4226051697C95444343 @default.

• next