Matches in SemOpenAlex for { <https://semopenalex.org/work/W4226070838> ?p ?o ?g. }
- W4226070838 abstract "Abstract G-protein coupled inwardly rectifying potassium (GIRK) channels are key players in inhibitory neurotransmission in heart and brain. We conducted molecular dynamics simulations to investigate the effect of a selectivity filter (SF) mutation, G154S, on GIRK2 structure and function. We observe mutation-induced loss of selectivity, changes in ion occupancy and altered filter geometry. Unexpectedly, we reveal aberrant SF dynamics in the mutant to be correlated with motions in the binding site of the channel activator Gβγ. This coupling is corroborated by electrophysiological experiments, revealing that GIRK2 wt activation by Gβγ reduces the affinity of Ba 2+ block. We further present a functional characterization of the human GIRK2 G154S mutant validating our computational findings. This study identifies an allosteric connection between the SF and a crucial activator binding site. This allosteric gating mechanism may also apply to other potassium channels that are modulated by accessory proteins." @default.
- W4226070838 created "2022-05-05" @default.
- W4226070838 creator A5006132677 @default.
- W4226070838 creator A5009058982 @default.
- W4226070838 creator A5033477963 @default.
- W4226070838 creator A5035447853 @default.
- W4226070838 creator A5053554450 @default.
- W4226070838 creator A5054988954 @default.
- W4226070838 creator A5061832576 @default.
- W4226070838 creator A5071063586 @default.
- W4226070838 creator A5084395646 @default.
- W4226070838 date "2022-04-11" @default.
- W4226070838 modified "2023-10-18" @default.
- W4226070838 title "A selectivity filter mutation provides insights into gating regulation of a K+ channel" @default.
- W4226070838 cites W1031578623 @default.
- W4226070838 cites W1492607105 @default.
- W4226070838 cites W1518056784 @default.
- W4226070838 cites W1594277617 @default.
- W4226070838 cites W1969356076 @default.
- W4226070838 cites W1981225934 @default.
- W4226070838 cites W1987232577 @default.
- W4226070838 cites W1991033228 @default.
- W4226070838 cites W1995952358 @default.
- W4226070838 cites W1997726536 @default.
- W4226070838 cites W2004736949 @default.
- W4226070838 cites W2007061409 @default.
- W4226070838 cites W2016555254 @default.
- W4226070838 cites W2018565348 @default.
- W4226070838 cites W2028317593 @default.
- W4226070838 cites W2030310238 @default.
- W4226070838 cites W2035166804 @default.
- W4226070838 cites W2035687084 @default.
- W4226070838 cites W2036260386 @default.
- W4226070838 cites W2040230882 @default.
- W4226070838 cites W2041051514 @default.
- W4226070838 cites W2043776403 @default.
- W4226070838 cites W2049475242 @default.
- W4226070838 cites W2054469296 @default.
- W4226070838 cites W2057228671 @default.
- W4226070838 cites W2057477511 @default.
- W4226070838 cites W2060012277 @default.
- W4226070838 cites W2060270263 @default.
- W4226070838 cites W2062346208 @default.
- W4226070838 cites W2081260116 @default.
- W4226070838 cites W2081693079 @default.
- W4226070838 cites W2081764386 @default.
- W4226070838 cites W2102246235 @default.
- W4226070838 cites W2113789703 @default.
- W4226070838 cites W2128572087 @default.
- W4226070838 cites W2128958818 @default.
- W4226070838 cites W2129646250 @default.
- W4226070838 cites W2131276706 @default.
- W4226070838 cites W2132243674 @default.
- W4226070838 cites W2138250649 @default.
- W4226070838 cites W2141494494 @default.
- W4226070838 cites W2144288821 @default.
- W4226070838 cites W2145170510 @default.
- W4226070838 cites W2153843155 @default.
- W4226070838 cites W2154780280 @default.
- W4226070838 cites W2158469559 @default.
- W4226070838 cites W2162598202 @default.
- W4226070838 cites W2191604030 @default.
- W4226070838 cites W2285869789 @default.
- W4226070838 cites W2474605288 @default.
- W4226070838 cites W2507433039 @default.
- W4226070838 cites W2517096290 @default.
- W4226070838 cites W2738141177 @default.
- W4226070838 cites W2802475651 @default.
- W4226070838 cites W2806096965 @default.
- W4226070838 cites W2883325391 @default.
- W4226070838 cites W2909605143 @default.
- W4226070838 cites W2972517328 @default.
- W4226070838 cites W2982396461 @default.
- W4226070838 cites W2990439682 @default.
- W4226070838 cites W3011293200 @default.
- W4226070838 cites W3081241911 @default.
- W4226070838 cites W3096948603 @default.
- W4226070838 cites W3107329155 @default.
- W4226070838 cites W3122745243 @default.
- W4226070838 cites W3194472259 @default.
- W4226070838 cites W4220968721 @default.
- W4226070838 cites W4299916937 @default.
- W4226070838 cites W51509680 @default.
- W4226070838 cites W1931048229 @default.
- W4226070838 doi "https://doi.org/10.1038/s42003-022-03303-1" @default.
- W4226070838 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35411015" @default.
- W4226070838 hasPublicationYear "2022" @default.
- W4226070838 type Work @default.
- W4226070838 citedByCount "1" @default.
- W4226070838 countsByYear W42260708382023 @default.
- W4226070838 crossrefType "journal-article" @default.
- W4226070838 hasAuthorship W4226070838A5006132677 @default.
- W4226070838 hasAuthorship W4226070838A5009058982 @default.
- W4226070838 hasAuthorship W4226070838A5033477963 @default.
- W4226070838 hasAuthorship W4226070838A5035447853 @default.
- W4226070838 hasAuthorship W4226070838A5053554450 @default.
- W4226070838 hasAuthorship W4226070838A5054988954 @default.
- W4226070838 hasAuthorship W4226070838A5061832576 @default.
- W4226070838 hasAuthorship W4226070838A5071063586 @default.
- W4226070838 hasAuthorship W4226070838A5084395646 @default.