FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4226074286> ?p ?o ?g. }

• W4226074286 abstract "Mosaic loss of Y chromosome (LOY) is the most common somatic change that occurs in circulating white blood cells of older men. LOY in leukocytes is associated with increased risk for all-cause mortality and a range of common disease such as hematological and non-hematological cancer, Alzheimer's disease, and cardiovascular events. Recent genome-wide association studies identified up to 156 germline variants associated with risk of LOY. The objective of this study was to use these variants to calculate a novel polygenic risk score (PRS) for LOY, and to assess the predictive performance of this score in a large independent population of older men.We calculated a PRS for LOY in 5131 men aged 70 years and older. Levels of LOY were estimated using microarrays and validated by whole genome sequencing. After adjusting for covariates, the PRS was a significant predictor of LOY (odds ratio [OR] = 1.74 per standard deviation of the PRS, 95% confidence intervals [CI] 1.62-1.86, p < 0.001). Men in the highest quintile of the PRS distribution had > fivefold higher risk of LOY than the lowest (OR = 5.05, 95% CI 4.05-6.32, p < 0.001). Adding the PRS to a LOY prediction model comprised of age, smoking and alcohol consumption significantly improved prediction (AUC = 0.628 [CI 0.61-0.64] to 0.695 [CI 0.67-0.71], p < 0.001).Our results suggest that a PRS for LOY could become a useful tool for risk prediction and targeted intervention for common disease in men." @default.
• W4226074286 created "2022-05-05" @default.
• W4226074286 creator A5001292564 @default.
• W4226074286 creator A5006713189 @default.
• W4226074286 creator A5038986974 @default.
• W4226074286 creator A5042187237 @default.
• W4226074286 creator A5049364469 @default.
• W4226074286 creator A5057379795 @default.
• W4226074286 creator A5062120099 @default.
• W4226074286 creator A5081228892 @default.
• W4226074286 creator A5088555276 @default.
• W4226074286 creator A5090656528 @default.
• W4226074286 date "2021-12-12" @default.
• W4226074286 modified "2023-10-03" @default.
• W4226074286 title "A polygenic risk score predicts mosaic loss of chromosome Y in circulating blood cells" @default.
• W4226074286 cites W158191276 @default.
• W4226074286 cites W1924244021 @default.
• W4226074286 cites W2014541905 @default.
• W4226074286 cites W2022174619 @default.
• W4226074286 cites W2040290929 @default.
• W4226074286 cites W2046886831 @default.
• W4226074286 cites W2057731718 @default.
• W4226074286 cites W2084194797 @default.
• W4226074286 cites W2089920619 @default.
• W4226074286 cites W2099085143 @default.
• W4226074286 cites W2104549677 @default.
• W4226074286 cites W2121743948 @default.
• W4226074286 cites W2145084170 @default.
• W4226074286 cites W2159393617 @default.
• W4226074286 cites W2161633633 @default.
• W4226074286 cites W2163104142 @default.
• W4226074286 cites W2222141405 @default.
• W4226074286 cites W2325975545 @default.
• W4226074286 cites W2328176404 @default.
• W4226074286 cites W2403642712 @default.
• W4226074286 cites W2510973425 @default.
• W4226074286 cites W2566323743 @default.
• W4226074286 cites W2588728606 @default.
• W4226074286 cites W2593251617 @default.
• W4226074286 cites W2599652322 @default.
• W4226074286 cites W2605722421 @default.
• W4226074286 cites W2724364141 @default.
• W4226074286 cites W2740242149 @default.
• W4226074286 cites W2799880655 @default.
• W4226074286 cites W2886173007 @default.
• W4226074286 cites W2889469195 @default.
• W4226074286 cites W2889884522 @default.
• W4226074286 cites W2891412296 @default.
• W4226074286 cites W2892288854 @default.
• W4226074286 cites W2897860657 @default.
• W4226074286 cites W2902268616 @default.
• W4226074286 cites W2981230482 @default.
• W4226074286 cites W2981923411 @default.
• W4226074286 cites W2990327991 @default.
• W4226074286 cites W2990625978 @default.
• W4226074286 cites W2998995497 @default.
• W4226074286 cites W3002728042 @default.
• W4226074286 cites W3005102891 @default.
• W4226074286 cites W3010598609 @default.
• W4226074286 cites W3010784781 @default.
• W4226074286 cites W3040344572 @default.
• W4226074286 cites W3104698488 @default.
• W4226074286 cites W3148534650 @default.
• W4226074286 cites W3185832339 @default.
• W4226074286 cites W3127917937 @default.
• W4226074286 doi "https://doi.org/10.1186/s13578-021-00716-z" @default.
• W4226074286 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34895331" @default.
• W4226074286 hasPublicationYear "2021" @default.
• W4226074286 type Work @default.
• W4226074286 citedByCount "5" @default.
• W4226074286 countsByYear W42260742862022 @default.
• W4226074286 countsByYear W42260742862023 @default.
• W4226074286 crossrefType "journal-article" @default.
• W4226074286 hasAuthorship W4226074286A5001292564 @default.
• W4226074286 hasAuthorship W4226074286A5006713189 @default.
• W4226074286 hasAuthorship W4226074286A5038986974 @default.
• W4226074286 hasAuthorship W4226074286A5042187237 @default.
• W4226074286 hasAuthorship W4226074286A5049364469 @default.
• W4226074286 hasAuthorship W4226074286A5057379795 @default.
• W4226074286 hasAuthorship W4226074286A5062120099 @default.
• W4226074286 hasAuthorship W4226074286A5081228892 @default.
• W4226074286 hasAuthorship W4226074286A5088555276 @default.
• W4226074286 hasAuthorship W4226074286A5090656528 @default.
• W4226074286 hasBestOaLocation W42260742861 @default.
• W4226074286 hasConcept C104317684 @default.
• W4226074286 hasConcept C11783203 @default.
• W4226074286 hasConcept C126322002 @default.
• W4226074286 hasConcept C135763542 @default.
• W4226074286 hasConcept C143998085 @default.
• W4226074286 hasConcept C153209595 @default.
• W4226074286 hasConcept C156957248 @default.
• W4226074286 hasConcept C2779134260 @default.
• W4226074286 hasConcept C2908647359 @default.
• W4226074286 hasConcept C2993137441 @default.
• W4226074286 hasConcept C44249647 @default.
• W4226074286 hasConcept C54355233 @default.
• W4226074286 hasConcept C71924100 @default.
• W4226074286 hasConcept C86803240 @default.
• W4226074286 hasConcept C99454951 @default.
• W4226074286 hasConceptScore W4226074286C104317684 @default.

• next