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- W4226079932 abstract "In Alzheimer's disease (AD), hyper-phosphorylation and aggregation of tau correlate with clinical progression and represent a valid therapeutic target. A recent 20-year prospective study revealed an association between moderate to high frequency of Finnish sauna bathing and a lower incidence of dementia and AD, but the molecular mechanisms underlying these benefits remain uncertain. Here, we tested the hypothesis that sauna-like conditions could lower tau phosphorylation by increasing body temperature. We observed a decrease in tau phosphorylation in wild-type and hTau mice as well as in neuron-like cells when exposed to higher temperatures. These effects were correlated with specific changes in phosphatase and kinase activities, but not with inflammatory or heat shock responses. We also used a drug strategy to promote thermogenesis: topical application of menthol, which led to a sustained increase in body temperature in hTau mice, concomitant with a significant decrease in tau phosphorylation. Our results suggest that sauna-like conditions or menthol treatment could lower tau pathology through mild hyperthermia, and may provide promising therapeutic strategies for AD and other tauopathies." @default.
- W4226079932 created "2022-05-05" @default.
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- W4226079932 creator A5082307853 @default.
- W4226079932 date "2022-05-01" @default.
- W4226079932 modified "2023-10-18" @default.
- W4226079932 title "Sauna-like conditions or menthol treatment reduce tau phosphorylation through mild hyperthermia" @default.
- W4226079932 cites W1482651457 @default.
- W4226079932 cites W1512263006 @default.
- W4226079932 cites W1540758658 @default.
- W4226079932 cites W1581594616 @default.
- W4226079932 cites W1603257718 @default.
- W4226079932 cites W1798323727 @default.
- W4226079932 cites W186368040 @default.
- W4226079932 cites W1888263661 @default.
- W4226079932 cites W1896340197 @default.
- W4226079932 cites W1954244449 @default.
- W4226079932 cites W1963866679 @default.
- W4226079932 cites W1967899481 @default.
- W4226079932 cites W1969979382 @default.
- W4226079932 cites W1975040221 @default.
- W4226079932 cites W1976489088 @default.
- W4226079932 cites W1988022281 @default.
- W4226079932 cites W1988332799 @default.
- W4226079932 cites W1994922654 @default.
- W4226079932 cites W1995330222 @default.
- W4226079932 cites W2001746866 @default.
- W4226079932 cites W2007219241 @default.
- W4226079932 cites W2018733438 @default.
- W4226079932 cites W2018823212 @default.
- W4226079932 cites W2021590064 @default.
- W4226079932 cites W2022178426 @default.
- W4226079932 cites W2022655041 @default.
- W4226079932 cites W2022768805 @default.
- W4226079932 cites W2024239281 @default.
- W4226079932 cites W2028005779 @default.
- W4226079932 cites W2032566236 @default.
- W4226079932 cites W2033341230 @default.
- W4226079932 cites W2036011584 @default.
- W4226079932 cites W2043661712 @default.
- W4226079932 cites W2046892908 @default.
- W4226079932 cites W2046948369 @default.
- W4226079932 cites W2054619408 @default.
- W4226079932 cites W2059363704 @default.
- W4226079932 cites W2063193894 @default.
- W4226079932 cites W2063509404 @default.
- W4226079932 cites W2064038516 @default.
- W4226079932 cites W2064934110 @default.
- W4226079932 cites W2067291975 @default.
- W4226079932 cites W2077859404 @default.
- W4226079932 cites W2078377364 @default.
- W4226079932 cites W2078599058 @default.
- W4226079932 cites W2079766520 @default.
- W4226079932 cites W2082209384 @default.
- W4226079932 cites W2088075448 @default.
- W4226079932 cites W2093650784 @default.
- W4226079932 cites W2097398649 @default.
- W4226079932 cites W2099257100 @default.
- W4226079932 cites W2100621873 @default.
- W4226079932 cites W2107057154 @default.
- W4226079932 cites W2115814152 @default.
- W4226079932 cites W2116411751 @default.
- W4226079932 cites W2118813218 @default.
- W4226079932 cites W2119257675 @default.
- W4226079932 cites W2123608334 @default.
- W4226079932 cites W2126279450 @default.
- W4226079932 cites W2130723719 @default.
- W4226079932 cites W2137903075 @default.
- W4226079932 cites W2138357260 @default.
- W4226079932 cites W2155048015 @default.
- W4226079932 cites W2158266441 @default.
- W4226079932 cites W2161965097 @default.
- W4226079932 cites W2162297135 @default.
- W4226079932 cites W2164136371 @default.
- W4226079932 cites W2165300686 @default.
- W4226079932 cites W2169720285 @default.
- W4226079932 cites W2189621653 @default.
- W4226079932 cites W2226005455 @default.
- W4226079932 cites W2226786300 @default.
- W4226079932 cites W2236088215 @default.
- W4226079932 cites W2255615413 @default.
- W4226079932 cites W2324851902 @default.
- W4226079932 cites W2512527296 @default.
- W4226079932 cites W2530884864 @default.
- W4226079932 cites W2533142483 @default.
- W4226079932 cites W2571262563 @default.
- W4226079932 cites W2583982124 @default.
- W4226079932 cites W2585490395 @default.
- W4226079932 cites W2589440020 @default.
- W4226079932 cites W2605036205 @default.