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- W4226082012 abstract "The analysis of circulating tumor DNA (ctDNA) turns out to be increasingly significant considering its potential value in the clinical diagnosis of cancer. Herein, a ctDNA electrochemical biosensor was developed with a low detection limit and high selectivity by using three-dimensional graphene-like homogeneous carbon architecture (3D-GHC600) loaded with gold-platinum (AuPt). The 3D-GHC600 was derived from the annealing process of copper-based metal-organic framework (denoted as Cu-BTC) at the optimal temperature (600 °C), which includes the merits of large area, rich mesopores, homogeneous size and morphology, and 3D structure. AuPt was formed on the 3D-GHC600 surface via an in-situ reduction reaction. Characterizations demonstrated that the resultant composite catalyst (AuPt/3D-GHC600) was prepared successfully and exhibited remarkable electrochemical properties. Further, the catalyst was used as a label of signal probes (SPs) to form SPs-label. The hybridization reactions were completed by layer-by-layer recognition of capture probes (CPs), target DNA (tDNA), and SPs-label on the electrode, thus forming a sandwich-like structure. The current signals of the SPs-label toward the electrocatalytic reduction of H2O2 were recorded in all tests for tDNA analysis. Accordingly, this recommended biosensor of tDNA showed good performance including a wide linear range of 10−8 M − 10−17 M with a detection limit of 2.25 × 10−18 M (S/N = 3), excellent selectivity for the recognition of different interferences, satisfying reproducibility, good stability, and outstanding recovery. These results demonstrated the promising application of the biosensor in the detection of ctDNA." @default.
- W4226082012 created "2022-05-05" @default.
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- W4226082012 date "2022-06-01" @default.
- W4226082012 modified "2023-10-18" @default.
- W4226082012 title "Three-dimensional graphene-like homogeneous carbon architecture loaded with gold-platinum for the electrochemical detection of circulating tumor DNA" @default.
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- W4226082012 doi "https://doi.org/10.1016/j.mtchem.2022.100892" @default.
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