FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4226083121> ?p ?o ?g. }

• W4226083121 abstract "You have accessJournal of UrologyCME1 May 2022MP45-12 PTEN LOSS AND DIFFUSIVE KI67 PREDICT BIOCHEMICAL RECURRENCE OF LOCALIZED PROSTATE CANCER AFTER RADICAL PROSTATECTOMY: A VALIDATION COHORT STUDY Che Hsueh Yang, Yi Sheng Lin, Wei Chun Weng, Chin Heng Lu, Chung Hsiao Chin, Tang Yi Tsao, Chao Yu Hsu, Min Che Tung, and Yen Chuan Ou Che Hsueh YangChe Hsueh Yang More articles by this author , Yi Sheng LinYi Sheng Lin More articles by this author , Wei Chun WengWei Chun Weng More articles by this author , Chin Heng LuChin Heng Lu More articles by this author , Chung Hsiao ChinChung Hsiao Chin More articles by this author , Tang Yi TsaoTang Yi Tsao More articles by this author , Chao Yu HsuChao Yu Hsu More articles by this author , Min Che TungMin Che Tung More articles by this author , and Yen Chuan OuYen Chuan Ou More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000002611.12AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Although Ki67 and PTEN emerge as promising markers of localized prostate cancer (PC) after radical prostatectomy (RP), they are still not recommended for routine risk assessments in guidelines. This study aims to validate their prognostic values in time-to- biochemical recurrence (BCR) of localized PC after RP. METHODS: Between 2015 and 2017, men of localized PC after robot-assisted RP were retrospectively reviewed. Their specimens were re-stained with immunohistochemical (IHC) markers of Ki67 and PTEN and were interpreted according to suggestions of International Society of Urological Pathology. Diffusive Ki67 was defined as 30% positivity (diffusive: Ki67+, non-diffusive: Ki67-) and PTEN was categorized into intact (PTEN +), heterogenous loss(PTEN-) and homogenous loss (PTEN 2-). Independent variables of Ki67 and PTEN were examined through univariable and multivariable Cox regression, and dependent variable was time-to-BCR. Other meaningful independent variables in univariable Cox regression would be incorporated into multivariable Cox regression analysis with Ki67 and PTEN. Kaplan Meier (KM) curve was applied to visualize and compare survival outcomes. RESULTS: A total of 215 men were reviewed with a mean surveillance of 66.85±6.62 months. Meaningful variables analyzed with Ki67 and PTEN in multivariable Cox regression were preoperative PSA, primary Gleason score, T stage, N stage, perineural invasion, angiolymphatic invasion,tumor percentage and positive surgical margins. In multivariable Cox regression of time-to-BCR, PTEN- (HR:1.95 (1.10-3.43)), PTEN 2- (HR:3.08 (1.78-5.35)) and Ki67+(HR:2.38 (1.47-3.83)) were significant factors. In KM curve, except for the comparison of Ki67-/PTEN 2- and Ki67+/PTEN+ (p=0.476), all subgroups comparisons were statistically significant (p<0.05). CONCLUSIONS: PTEN 2-, PTEN - and Ki67+ are all related to BCR of localized PC after RP. Judging from KM curve, Ki67+ and PTEN 2- are in higher risks developing BCR than PTEN -, and PTEN 2- is equivalent to Ki67+ in predicting BCR after RP. Source of Funding: Nothing to disclose © 2022 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 207Issue Supplement 5May 2022Page: e767 Advertisement Copyright & Permissions© 2022 by American Urological Association Education and Research, Inc.MetricsAuthor Information Che Hsueh Yang More articles by this author Yi Sheng Lin More articles by this author Wei Chun Weng More articles by this author Chin Heng Lu More articles by this author Chung Hsiao Chin More articles by this author Tang Yi Tsao More articles by this author Chao Yu Hsu More articles by this author Min Che Tung More articles by this author Yen Chuan Ou More articles by this author Expand All Advertisement PDF DownloadLoading ..." @default.
• W4226083121 created "2022-05-05" @default.
• W4226083121 creator A5025851216 @default.
• W4226083121 creator A5031487364 @default.
• W4226083121 creator A5042924351 @default.
• W4226083121 creator A5049476572 @default.
• W4226083121 creator A5049650135 @default.
• W4226083121 creator A5055597096 @default.
• W4226083121 creator A5060204103 @default.
• W4226083121 creator A5061753773 @default.
• W4226083121 creator A5076633444 @default.
• W4226083121 date "2022-05-01" @default.
• W4226083121 modified "2023-10-12" @default.
• W4226083121 title "MP45-12 PTEN LOSS AND DIFFUSIVE KI67 PREDICT BIOCHEMICAL RECURRENCE OF LOCALIZED PROSTATE CANCER AFTER RADICAL PROSTATECTOMY: A VALIDATION COHORT STUDY" @default.
• W4226083121 doi "https://doi.org/10.1097/ju.0000000000002611.12" @default.
• W4226083121 hasPublicationYear "2022" @default.
• W4226083121 type Work @default.
• W4226083121 citedByCount "0" @default.
• W4226083121 crossrefType "journal-article" @default.
• W4226083121 hasAuthorship W4226083121A5025851216 @default.
• W4226083121 hasAuthorship W4226083121A5031487364 @default.
• W4226083121 hasAuthorship W4226083121A5042924351 @default.
• W4226083121 hasAuthorship W4226083121A5049476572 @default.
• W4226083121 hasAuthorship W4226083121A5049650135 @default.
• W4226083121 hasAuthorship W4226083121A5055597096 @default.
• W4226083121 hasAuthorship W4226083121A5060204103 @default.
• W4226083121 hasAuthorship W4226083121A5061753773 @default.
• W4226083121 hasAuthorship W4226083121A5076633444 @default.
• W4226083121 hasConcept C105702510 @default.
• W4226083121 hasConcept C121608353 @default.
• W4226083121 hasConcept C126322002 @default.
• W4226083121 hasConcept C126894567 @default.
• W4226083121 hasConcept C143998085 @default.
• W4226083121 hasConcept C185592680 @default.
• W4226083121 hasConcept C190283241 @default.
• W4226083121 hasConcept C204232928 @default.
• W4226083121 hasConcept C2777008409 @default.
• W4226083121 hasConcept C2777609662 @default.
• W4226083121 hasConcept C2779466945 @default.
• W4226083121 hasConcept C2779881321 @default.
• W4226083121 hasConcept C2780192828 @default.
• W4226083121 hasConcept C55493867 @default.
• W4226083121 hasConcept C71924100 @default.
• W4226083121 hasConcept C72563966 @default.
• W4226083121 hasConcept C86554907 @default.
• W4226083121 hasConceptScore W4226083121C105702510 @default.
• W4226083121 hasConceptScore W4226083121C121608353 @default.
• W4226083121 hasConceptScore W4226083121C126322002 @default.
• W4226083121 hasConceptScore W4226083121C126894567 @default.
• W4226083121 hasConceptScore W4226083121C143998085 @default.
• W4226083121 hasConceptScore W4226083121C185592680 @default.
• W4226083121 hasConceptScore W4226083121C190283241 @default.
• W4226083121 hasConceptScore W4226083121C204232928 @default.
• W4226083121 hasConceptScore W4226083121C2777008409 @default.
• W4226083121 hasConceptScore W4226083121C2777609662 @default.
• W4226083121 hasConceptScore W4226083121C2779466945 @default.
• W4226083121 hasConceptScore W4226083121C2779881321 @default.
• W4226083121 hasConceptScore W4226083121C2780192828 @default.
• W4226083121 hasConceptScore W4226083121C55493867 @default.
• W4226083121 hasConceptScore W4226083121C71924100 @default.
• W4226083121 hasConceptScore W4226083121C72563966 @default.
• W4226083121 hasConceptScore W4226083121C86554907 @default.
• W4226083121 hasIssue "Supplement 5" @default.
• W4226083121 hasLocation W42260831211 @default.
• W4226083121 hasOpenAccess W4226083121 @default.
• W4226083121 hasPrimaryLocation W42260831211 @default.
• W4226083121 hasRelatedWork W2026113581 @default.
• W4226083121 hasRelatedWork W2072198445 @default.
• W4226083121 hasRelatedWork W2116884624 @default.
• W4226083121 hasRelatedWork W2325390404 @default.
• W4226083121 hasRelatedWork W2559494340 @default.
• W4226083121 hasRelatedWork W2732526761 @default.
• W4226083121 hasRelatedWork W2895347925 @default.
• W4226083121 hasRelatedWork W2972701944 @default.
• W4226083121 hasRelatedWork W3150909901 @default.
• W4226083121 hasRelatedWork W3197039060 @default.
• W4226083121 hasVolume "207" @default.
• W4226083121 isParatext "false" @default.
• W4226083121 isRetracted "false" @default.
• W4226083121 workType "article" @default.