Matches in SemOpenAlex for { <https://semopenalex.org/work/W4226084265> ?p ?o ?g. }
Showing items 1 to 59 of
59
with 100 items per page.
- W4226084265 abstract "Abstract The V-domain immunoglobulin suppressor of T cell activation (VISTA) is thought to be a non-redundant T cell regulation checkpoint of the PD-1/PD-L1 axis. VISTA has recently emerged as an anti-tumor immunotherapy agent. To understand the genomic and immunological signatures of VISTA, we evaluated its expression levels, prognostic effects, mutation and copy number alterations, and immune infiltration signatures by pan-cancer analysis via multiple public datasets. Relative to normal tissues, tumour tissues frequently exhibit VISTA downregulation. Survival and immune infiltration signature analyses indicated that VISTA expression was differently correlated with outcome and immune infiltration level among various cancer types. Nevertheless, VISTA upregulation increased the survival and immune infiltration levels in breast, lung, and skin cancers but did not markedly improve survival and was only weakly correlated with the immune infiltration level in ovarian cancer. The VISTA pan-cancer mutation rate was almost 2%. The major mutation type was missense, followed by synonymous substitution with C>T. Functional annotation and pathway enrichment analyses revealed that VISTA-related genes and proteins participated in the T cell and Toll-like receptor signalling pathways, innate immune and inflammatory responses, and negative regulation of NF-κB transcription and interleukins. The foregoing results may help clarify the mechanism of VISTA in tumour immune response." @default.
- W4226084265 created "2022-05-05" @default.
- W4226084265 creator A5034036616 @default.
- W4226084265 creator A5058288595 @default.
- W4226084265 creator A5074408138 @default.
- W4226084265 date "2022-03-17" @default.
- W4226084265 modified "2023-10-15" @default.
- W4226084265 title "The Genomic and Immunologic Signature of VISTA Based on a Pan-cancer Analysis" @default.
- W4226084265 doi "https://doi.org/10.21203/rs.3.rs-1383203/v1" @default.
- W4226084265 hasPublicationYear "2022" @default.
- W4226084265 type Work @default.
- W4226084265 citedByCount "0" @default.
- W4226084265 crossrefType "posted-content" @default.
- W4226084265 hasAuthorship W4226084265A5034036616 @default.
- W4226084265 hasAuthorship W4226084265A5058288595 @default.
- W4226084265 hasAuthorship W4226084265A5074408138 @default.
- W4226084265 hasBestOaLocation W42260842651 @default.
- W4226084265 hasConcept C104317684 @default.
- W4226084265 hasConcept C127561419 @default.
- W4226084265 hasConcept C136449434 @default.
- W4226084265 hasConcept C159654299 @default.
- W4226084265 hasConcept C203014093 @default.
- W4226084265 hasConcept C2777701055 @default.
- W4226084265 hasConcept C2780851360 @default.
- W4226084265 hasConcept C501734568 @default.
- W4226084265 hasConcept C502942594 @default.
- W4226084265 hasConcept C54355233 @default.
- W4226084265 hasConcept C75563809 @default.
- W4226084265 hasConcept C86803240 @default.
- W4226084265 hasConcept C8891405 @default.
- W4226084265 hasConceptScore W4226084265C104317684 @default.
- W4226084265 hasConceptScore W4226084265C127561419 @default.
- W4226084265 hasConceptScore W4226084265C136449434 @default.
- W4226084265 hasConceptScore W4226084265C159654299 @default.
- W4226084265 hasConceptScore W4226084265C203014093 @default.
- W4226084265 hasConceptScore W4226084265C2777701055 @default.
- W4226084265 hasConceptScore W4226084265C2780851360 @default.
- W4226084265 hasConceptScore W4226084265C501734568 @default.
- W4226084265 hasConceptScore W4226084265C502942594 @default.
- W4226084265 hasConceptScore W4226084265C54355233 @default.
- W4226084265 hasConceptScore W4226084265C75563809 @default.
- W4226084265 hasConceptScore W4226084265C86803240 @default.
- W4226084265 hasConceptScore W4226084265C8891405 @default.
- W4226084265 hasLocation W42260842651 @default.
- W4226084265 hasOpenAccess W4226084265 @default.
- W4226084265 hasPrimaryLocation W42260842651 @default.
- W4226084265 hasRelatedWork W1379988 @default.
- W4226084265 hasRelatedWork W1413525 @default.
- W4226084265 hasRelatedWork W19799706 @default.
- W4226084265 hasRelatedWork W28840701 @default.
- W4226084265 hasRelatedWork W29620779 @default.
- W4226084265 hasRelatedWork W34010751 @default.
- W4226084265 hasRelatedWork W34501487 @default.
- W4226084265 hasRelatedWork W38272178 @default.
- W4226084265 hasRelatedWork W6050890 @default.
- W4226084265 hasRelatedWork W8270909 @default.
- W4226084265 isParatext "false" @default.
- W4226084265 isRetracted "false" @default.
- W4226084265 workType "article" @default.