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- W4226088112 abstract "Abstract Cancers are a collection of incapacitating diseases in which cells initiate to divide and spread to adjacent tissues in an uncontrolled manner. Many researches demonstrated the potential of bacterial pigments as promising anticancer agents Therefore, in this study, the cytotoxic effects of bacterial pigments were evaluated in breast and colon cancer cell lines. In this study, a total of 90 samples were collected from air, water, and soil from 28 different geographical areas of Iran. Forty isolates were selected based on differences in colony color and geographic regions. The MTT assay was used to evaluate the effect of pigment on MCF-7 and SW-48 cells. Bacteria whose pigment had the highest cytotoxic effect on cell lines were selected. Accurate identification was performed using PCR, and their relative purity was measured using TLC. Bacteria isolated from any three ecosystems are capable of producing pigments. Pigment-producing bacteria are more abundant in the soil than air and water. Among pigment-producing bacteria, 3 isolates had the highest cytotoxicity on MCF-7 cells, and 3 isolates had the greatest effect on SW-48 cells. The results of sequencing of isolates at the BLAST site showed that 6 isolates with cytotoxic effects were identified ( Micrococcus xinjiangensis , Dietzia , Arthrobacter agilis, Exigubacterium mexicanum , Bacillus beijingensis ). Chromatography shows that these pigmented bacteria have different pigment components.Pigment extraction from bacteria can be used as a complementary therapy or other therapies for breast and colon cancer in the future." @default.
- W4226088112 created "2022-05-05" @default.
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- W4226088112 date "2022-04-19" @default.
- W4226088112 modified "2023-09-27" @default.
- W4226088112 title "Evaluation of the effects of pigments produced by environmental bacteria on cancer cells" @default.
- W4226088112 doi "https://doi.org/10.21203/rs.3.rs-1105751/v2" @default.
- W4226088112 hasPublicationYear "2022" @default.
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