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- W4226089802 abstract "Previous works have shown that zearalenone (ZEA), as an estrogenic pollutant, has adverse effects on mammalian folliculogenesis. In the present study, we found that prolonged exposure of female mice to ZEA around the end of pregnancy caused severe impairment of primordial follicle formation in the ovaries of newborn mice and altered the expression of many genes in oocytes as revealed by single-cell RNA sequencing (scRNA-seq). These changes were associated with morphological and molecular alterations of mitochondria, increased autophagic markers in oocytes, and epigenetic changes in the ovaries of newborn mice from ZEA-exposed mothers. The latter increased expression of HDAC2 deacetylases was leading to decreased levels of H3K9ac and H4K12ac. Most of these modifications were relieved when the expression of Hdac2 in newborn ovaries was reduced by RNA interference during in vitro culture in the presence of ZEA. Such changes were also alleviated in offspring ovaries from mothers treated with both ZEA and the coenzyme Q10 (CoQ10), which is known to be able to restore mitochondrial activities. We concluded that impaired mitochondrial activities in oocytes caused by ZEA are at the origin of metabolic alterations that modify the expression of genes controlling autophagy and primordial follicle assembly through changes in epigenetic histones." @default.
- W4226089802 created "2022-05-05" @default.
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- W4226089802 date "2022-04-26" @default.
- W4226089802 modified "2023-10-08" @default.
- W4226089802 title "Impaired primordial follicle assembly in offspring ovaries from zearalenone-exposed mothers involves reduced mitochondrial activity and altered epigenetics in oocytes" @default.
- W4226089802 cites W1487070667 @default.
- W4226089802 cites W1553155385 @default.
- W4226089802 cites W1575189699 @default.
- W4226089802 cites W1949822692 @default.
- W4226089802 cites W1972266551 @default.
- W4226089802 cites W1995276261 @default.
- W4226089802 cites W2002927783 @default.
- W4226089802 cites W2022018162 @default.
- W4226089802 cites W2042434654 @default.
- W4226089802 cites W2046716387 @default.
- W4226089802 cites W2050532980 @default.
- W4226089802 cites W2060364936 @default.
- W4226089802 cites W2061320431 @default.
- W4226089802 cites W2072844557 @default.
- W4226089802 cites W2074261055 @default.
- W4226089802 cites W2085150290 @default.
- W4226089802 cites W2086655682 @default.
- W4226089802 cites W2095000965 @default.
- W4226089802 cites W2100413434 @default.
- W4226089802 cites W2100876394 @default.
- W4226089802 cites W2114413271 @default.
- W4226089802 cites W2131438908 @default.
- W4226089802 cites W2135758370 @default.
- W4226089802 cites W2136503478 @default.
- W4226089802 cites W2168744563 @default.
- W4226089802 cites W2178637762 @default.
- W4226089802 cites W2238637024 @default.
- W4226089802 cites W2340087533 @default.
- W4226089802 cites W2344651444 @default.
- W4226089802 cites W2515036978 @default.
- W4226089802 cites W2578802873 @default.
- W4226089802 cites W2587517962 @default.
- W4226089802 cites W2588557803 @default.
- W4226089802 cites W2595363380 @default.
- W4226089802 cites W2607562467 @default.
- W4226089802 cites W2611604673 @default.
- W4226089802 cites W2619419337 @default.
- W4226089802 cites W2620117134 @default.
- W4226089802 cites W2624934949 @default.
- W4226089802 cites W2767172151 @default.
- W4226089802 cites W2769518155 @default.
- W4226089802 cites W2770715322 @default.
- W4226089802 cites W2784328279 @default.
- W4226089802 cites W2806092358 @default.
- W4226089802 cites W2806977025 @default.
- W4226089802 cites W2883257411 @default.
- W4226089802 cites W2898430398 @default.
- W4226089802 cites W2934744260 @default.
- W4226089802 cites W2956078079 @default.
- W4226089802 cites W2971157369 @default.
- W4226089802 cites W2980244547 @default.
- W4226089802 cites W2981218333 @default.
- W4226089802 cites W2990171578 @default.
- W4226089802 cites W2991479732 @default.
- W4226089802 cites W2997036293 @default.
- W4226089802 cites W3002203064 @default.
- W4226089802 cites W3004127014 @default.
- W4226089802 cites W3007013004 @default.
- W4226089802 cites W3021021855 @default.
- W4226089802 cites W3028816559 @default.
- W4226089802 cites W3033619070 @default.
- W4226089802 cites W3046899611 @default.
- W4226089802 cites W3047055630 @default.
- W4226089802 cites W3047337201 @default.
- W4226089802 cites W3047354140 @default.
- W4226089802 cites W3049103159 @default.
- W4226089802 cites W3084172866 @default.
- W4226089802 cites W3087696848 @default.
- W4226089802 cites W3091637827 @default.
- W4226089802 cites W3106286382 @default.
- W4226089802 cites W3107793053 @default.
- W4226089802 cites W3108397438 @default.
- W4226089802 cites W3114323970 @default.
- W4226089802 cites W3115309851 @default.
- W4226089802 cites W3118104863 @default.
- W4226089802 cites W3118521001 @default.
- W4226089802 cites W3119680760 @default.
- W4226089802 cites W3136379023 @default.
- W4226089802 cites W3137277001 @default.
- W4226089802 cites W3158170171 @default.
- W4226089802 cites W3160658419 @default.
- W4226089802 cites W3164602447 @default.
- W4226089802 cites W3173256764 @default.
- W4226089802 doi "https://doi.org/10.1007/s00018-022-04288-0" @default.
- W4226089802 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35469021" @default.
- W4226089802 hasPublicationYear "2022" @default.
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