FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4226093337> ?p ?o ?g. }

• W4226093337 abstract "The kinase mTOR is a signaling hub for pathways that regulate cellular growth. In neurons, the subcellular localization of mTOR takes on increased significance. Here, we review findings on the localization of mTOR in axons and offer a perspective on how these may impact our understanding of nervous system development, function, and disease. We propose a model where mTOR accumulates in local foci we term mTOR outposts, which can be found in processes distant from a neuron’s cell body. In this model, pathways that funnel through mTOR are gated by local outposts to spatially select and amplify local signaling. The presence or absence of mTOR outposts in a segment of axon or dendrite may determine whether regional mTOR-dependent signals, such as nutrient and growth factor signaling, register toward neuron-wide responses. In this perspective, we present the emerging evidence for mTOR outposts in neurons, their putative roles as spatial gatekeepers of signaling inputs, and the implications of the mTOR outpost model for neuronal protein synthesis, signal transduction, and synaptic plasticity." @default.
• W4226093337 created "2022-05-05" @default.
• W4226093337 creator A5018262904 @default.
• W4226093337 creator A5025873184 @default.
• W4226093337 creator A5050103948 @default.
• W4226093337 creator A5087786020 @default.
• W4226093337 date "2022-04-07" @default.
• W4226093337 modified "2023-09-26" @default.
• W4226093337 title "Neuronal mTOR Outposts: Implications for Translation, Signaling, and Plasticity" @default.
• W4226093337 cites W1523304533 @default.
• W4226093337 cites W1600856176 @default.
• W4226093337 cites W1963688091 @default.
• W4226093337 cites W1966516510 @default.
• W4226093337 cites W1966901093 @default.
• W4226093337 cites W1972087054 @default.
• W4226093337 cites W1973109734 @default.
• W4226093337 cites W1976392245 @default.
• W4226093337 cites W1981006540 @default.
• W4226093337 cites W1981097208 @default.
• W4226093337 cites W1987030209 @default.
• W4226093337 cites W2003982930 @default.
• W4226093337 cites W2012480785 @default.
• W4226093337 cites W2014295524 @default.
• W4226093337 cites W2014722170 @default.
• W4226093337 cites W2021512296 @default.
• W4226093337 cites W2024451767 @default.
• W4226093337 cites W2028489659 @default.
• W4226093337 cites W2042573239 @default.
• W4226093337 cites W2049883153 @default.
• W4226093337 cites W2053955820 @default.
• W4226093337 cites W2056001326 @default.
• W4226093337 cites W2056772716 @default.
• W4226093337 cites W2065323140 @default.
• W4226093337 cites W2069292824 @default.
• W4226093337 cites W2072298966 @default.
• W4226093337 cites W2074375304 @default.
• W4226093337 cites W2086236919 @default.
• W4226093337 cites W2089351762 @default.
• W4226093337 cites W2091285282 @default.
• W4226093337 cites W2100155309 @default.
• W4226093337 cites W2103739793 @default.
• W4226093337 cites W2117002197 @default.
• W4226093337 cites W2124825357 @default.
• W4226093337 cites W2136272779 @default.
• W4226093337 cites W2140937954 @default.
• W4226093337 cites W2164965868 @default.
• W4226093337 cites W2237564533 @default.
• W4226093337 cites W2291443053 @default.
• W4226093337 cites W2319350350 @default.
• W4226093337 cites W2354407467 @default.
• W4226093337 cites W2469298590 @default.
• W4226093337 cites W2536391716 @default.
• W4226093337 cites W2583725498 @default.
• W4226093337 cites W2588806647 @default.
• W4226093337 cites W2593816418 @default.
• W4226093337 cites W2745057783 @default.
• W4226093337 cites W2766243612 @default.
• W4226093337 cites W2789909579 @default.
• W4226093337 cites W2797718870 @default.
• W4226093337 cites W2887287746 @default.
• W4226093337 cites W2889261354 @default.
• W4226093337 cites W2897395578 @default.
• W4226093337 cites W2898928876 @default.
• W4226093337 cites W2903713826 @default.
• W4226093337 cites W2909422392 @default.
• W4226093337 cites W2913556175 @default.
• W4226093337 cites W2945232783 @default.
• W4226093337 cites W2949232106 @default.
• W4226093337 cites W2953683903 @default.
• W4226093337 cites W2979459757 @default.
• W4226093337 cites W2995312562 @default.
• W4226093337 cites W3007521094 @default.
• W4226093337 cites W3042760041 @default.
• W4226093337 cites W3101190292 @default.
• W4226093337 cites W3130488722 @default.
• W4226093337 cites W3198140022 @default.
• W4226093337 cites W3207078712 @default.
• W4226093337 doi "https://doi.org/10.3389/fncel.2022.853634" @default.
• W4226093337 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35465614" @default.
• W4226093337 hasPublicationYear "2022" @default.
• W4226093337 type Work @default.
• W4226093337 citedByCount "2" @default.
• W4226093337 countsByYear W42260933372023 @default.
• W4226093337 crossrefType "journal-article" @default.
• W4226093337 hasAuthorship W4226093337A5018262904 @default.
• W4226093337 hasAuthorship W4226093337A5025873184 @default.
• W4226093337 hasAuthorship W4226093337A5050103948 @default.
• W4226093337 hasAuthorship W4226093337A5087786020 @default.
• W4226093337 hasBestOaLocation W42260933371 @default.
• W4226093337 hasConcept C104317684 @default.
• W4226093337 hasConcept C105580179 @default.
• W4226093337 hasConcept C149364088 @default.
• W4226093337 hasConcept C169760540 @default.
• W4226093337 hasConcept C170493617 @default.
• W4226093337 hasConcept C2779530196 @default.
• W4226093337 hasConcept C2909523446 @default.
• W4226093337 hasConcept C4746552 @default.
• W4226093337 hasConcept C54355233 @default.
• W4226093337 hasConcept C62478195 @default.
• W4226093337 hasConcept C86554907 @default.

• next