Matches in SemOpenAlex for { <https://semopenalex.org/work/W4226101143> ?p ?o ?g. }
- W4226101143 abstract "Despite antigen affinity of B cells varying from cell to cell, functional analyses of antigen-reactive B cells on individual B cells are missing due to technical difficulties. Especially in the field of autoimmune diseases, promising pathogenic B cells have not been adequately studied to date because of its rarity. In this study, functions of autoantigen-reactive B cells in autoimmune disease were analyzed at the single-cell level. Since topoisomerase I is a distinct autoantigen, we targeted systemic sclerosis as autoimmune disease. Decreased and increased affinities for topoisomerase I of topoisomerase I-reactive B cells led to anti-inflammatory and pro-inflammatory cytokine production associated with the inhibition and development of fibrosis, which is the major symptom of systemic sclerosis. Furthermore, inhibition of pro-inflammatory cytokine production and increased affinity of topoisomerase I-reactive B cells suppressed fibrosis. These results indicate that autoantigen-reactive B cells contribute to the disease manifestations in autoimmune disease through their antigen affinity." @default.
- W4226101143 created "2022-05-05" @default.
- W4226101143 creator A5007508591 @default.
- W4226101143 creator A5016934524 @default.
- W4226101143 creator A5019299627 @default.
- W4226101143 creator A5022897413 @default.
- W4226101143 creator A5033923183 @default.
- W4226101143 creator A5040282514 @default.
- W4226101143 creator A5045059471 @default.
- W4226101143 creator A5055017117 @default.
- W4226101143 creator A5068827161 @default.
- W4226101143 creator A5073032934 @default.
- W4226101143 creator A5085069960 @default.
- W4226101143 date "2021-12-02" @default.
- W4226101143 modified "2023-09-30" @default.
- W4226101143 title "Single-cell-level protein analysis revealing the roles of autoantigen-reactive B lymphocytes in autoimmune disease and the murine model" @default.
- W4226101143 cites W1970705584 @default.
- W4226101143 cites W1996882626 @default.
- W4226101143 cites W2003064316 @default.
- W4226101143 cites W2009501393 @default.
- W4226101143 cites W2027949435 @default.
- W4226101143 cites W2028921539 @default.
- W4226101143 cites W2052599602 @default.
- W4226101143 cites W2053889945 @default.
- W4226101143 cites W2057800919 @default.
- W4226101143 cites W2063264144 @default.
- W4226101143 cites W2065142023 @default.
- W4226101143 cites W2069094983 @default.
- W4226101143 cites W2075400164 @default.
- W4226101143 cites W2078066300 @default.
- W4226101143 cites W2100274551 @default.
- W4226101143 cites W2105577215 @default.
- W4226101143 cites W2111310940 @default.
- W4226101143 cites W2121855655 @default.
- W4226101143 cites W2132531551 @default.
- W4226101143 cites W2147925625 @default.
- W4226101143 cites W2167935917 @default.
- W4226101143 cites W2234483047 @default.
- W4226101143 cites W2347093301 @default.
- W4226101143 cites W2485267084 @default.
- W4226101143 cites W2588874415 @default.
- W4226101143 cites W2592584994 @default.
- W4226101143 cites W2618952129 @default.
- W4226101143 cites W2765490201 @default.
- W4226101143 cites W2808835989 @default.
- W4226101143 cites W2840657406 @default.
- W4226101143 cites W2886240927 @default.
- W4226101143 cites W2918542982 @default.
- W4226101143 cites W2924576972 @default.
- W4226101143 cites W2949836700 @default.
- W4226101143 cites W2974215443 @default.
- W4226101143 cites W2980604767 @default.
- W4226101143 cites W3165411983 @default.
- W4226101143 cites W908721847 @default.
- W4226101143 doi "https://doi.org/10.7554/elife.67209" @default.
- W4226101143 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34854378" @default.
- W4226101143 hasPublicationYear "2021" @default.
- W4226101143 type Work @default.
- W4226101143 citedByCount "23" @default.
- W4226101143 countsByYear W42261011432022 @default.
- W4226101143 countsByYear W42261011432023 @default.
- W4226101143 crossrefType "journal-article" @default.
- W4226101143 hasAuthorship W4226101143A5007508591 @default.
- W4226101143 hasAuthorship W4226101143A5016934524 @default.
- W4226101143 hasAuthorship W4226101143A5019299627 @default.
- W4226101143 hasAuthorship W4226101143A5022897413 @default.
- W4226101143 hasAuthorship W4226101143A5033923183 @default.
- W4226101143 hasAuthorship W4226101143A5040282514 @default.
- W4226101143 hasAuthorship W4226101143A5045059471 @default.
- W4226101143 hasAuthorship W4226101143A5055017117 @default.
- W4226101143 hasAuthorship W4226101143A5068827161 @default.
- W4226101143 hasAuthorship W4226101143A5073032934 @default.
- W4226101143 hasAuthorship W4226101143A5085069960 @default.
- W4226101143 hasBestOaLocation W42261011431 @default.
- W4226101143 hasConcept C147483822 @default.
- W4226101143 hasConcept C159654299 @default.
- W4226101143 hasConcept C203014093 @default.
- W4226101143 hasConcept C2778453870 @default.
- W4226101143 hasConcept C2778690821 @default.
- W4226101143 hasConcept C2779075594 @default.
- W4226101143 hasConcept C2780130043 @default.
- W4226101143 hasConcept C86803240 @default.
- W4226101143 hasConceptScore W4226101143C147483822 @default.
- W4226101143 hasConceptScore W4226101143C159654299 @default.
- W4226101143 hasConceptScore W4226101143C203014093 @default.
- W4226101143 hasConceptScore W4226101143C2778453870 @default.
- W4226101143 hasConceptScore W4226101143C2778690821 @default.
- W4226101143 hasConceptScore W4226101143C2779075594 @default.
- W4226101143 hasConceptScore W4226101143C2780130043 @default.
- W4226101143 hasConceptScore W4226101143C86803240 @default.
- W4226101143 hasLocation W42261011431 @default.
- W4226101143 hasLocation W42261011432 @default.
- W4226101143 hasLocation W42261011433 @default.
- W4226101143 hasLocation W42261011434 @default.
- W4226101143 hasOpenAccess W4226101143 @default.
- W4226101143 hasPrimaryLocation W42261011431 @default.
- W4226101143 hasRelatedWork W161285251 @default.
- W4226101143 hasRelatedWork W1996550726 @default.
- W4226101143 hasRelatedWork W2037083575 @default.
- W4226101143 hasRelatedWork W2040191638 @default.