Matches in SemOpenAlex for { <https://semopenalex.org/work/W4226109959> ?p ?o ?g. }
- W4226109959 endingPage "11" @default.
- W4226109959 startingPage "3" @default.
- W4226109959 abstract "Heterogeneity is a pervasive feature of cancer, and understanding the sources and regulatory mechanisms underlying heterogeneity could provide key insights to help improve the diagnosis and treatment of cancer. In this review, we discuss the origin of heterogeneity in the phenotype of individual cancer cells. Genotype-phenotype (G-P) maps are widely used in evolutionary biology to represent the complex interactions of genes and the environment that lead to phenotypes that impact fitness. Here, we present the rationale of an extended G-P (eG-P) map with a cone structure in cancer. The eG-P cone is formed by cells that are similar at the genome layer but gradually increase variability in the epigenome, transcriptome, proteome, metabolome, and signalome layers to produce large variability at the phenome layer. Experimental evidence from single-cell-omics analyses supporting the cancer eG-P cone concept is presented, and the impact of epimutations and the interaction of cancer and tumor microenvironmental eG-P cones are integrated with the current understanding of cancer biology. The eG-P cone concept uncovers potential therapeutic strategies to reduce cancer evolution and improve cancer treatment. More methods to study phenotypes in single cells will be the key to better understand cancer cell fitness in tumor biology and therapeutics." @default.
- W4226109959 created "2022-05-05" @default.
- W4226109959 creator A5007601785 @default.
- W4226109959 creator A5031267351 @default.
- W4226109959 creator A5063771938 @default.
- W4226109959 creator A5065138948 @default.
- W4226109959 creator A5065393698 @default.
- W4226109959 creator A5069797000 @default.
- W4226109959 date "2022-01-01" @default.
- W4226109959 modified "2023-10-17" @default.
- W4226109959 title "The Origins of Phenotypic Heterogeneity in Cancer" @default.
- W4226109959 cites W1965458767 @default.
- W4226109959 cites W1975466959 @default.
- W4226109959 cites W1978518799 @default.
- W4226109959 cites W1984571004 @default.
- W4226109959 cites W1997982747 @default.
- W4226109959 cites W2007452808 @default.
- W4226109959 cites W2009430092 @default.
- W4226109959 cites W2011637823 @default.
- W4226109959 cites W2013875639 @default.
- W4226109959 cites W2018288777 @default.
- W4226109959 cites W2038592503 @default.
- W4226109959 cites W2044339772 @default.
- W4226109959 cites W2049491375 @default.
- W4226109959 cites W2049820772 @default.
- W4226109959 cites W2066218351 @default.
- W4226109959 cites W2073302269 @default.
- W4226109959 cites W2078490888 @default.
- W4226109959 cites W2083086786 @default.
- W4226109959 cites W2093279379 @default.
- W4226109959 cites W2106391833 @default.
- W4226109959 cites W2111510713 @default.
- W4226109959 cites W2114123456 @default.
- W4226109959 cites W2116910749 @default.
- W4226109959 cites W2139015332 @default.
- W4226109959 cites W2146447332 @default.
- W4226109959 cites W2157150618 @default.
- W4226109959 cites W2158485828 @default.
- W4226109959 cites W2170343590 @default.
- W4226109959 cites W2171642372 @default.
- W4226109959 cites W2286667211 @default.
- W4226109959 cites W2320523858 @default.
- W4226109959 cites W2321162622 @default.
- W4226109959 cites W2332292689 @default.
- W4226109959 cites W2337546159 @default.
- W4226109959 cites W2586629973 @default.
- W4226109959 cites W2587686129 @default.
- W4226109959 cites W2588969809 @default.
- W4226109959 cites W2600453489 @default.
- W4226109959 cites W2603587832 @default.
- W4226109959 cites W2604169508 @default.
- W4226109959 cites W2607167117 @default.
- W4226109959 cites W2612496317 @default.
- W4226109959 cites W2621895366 @default.
- W4226109959 cites W2739492614 @default.
- W4226109959 cites W2742763599 @default.
- W4226109959 cites W2746288782 @default.
- W4226109959 cites W2767281692 @default.
- W4226109959 cites W2783417222 @default.
- W4226109959 cites W2786031287 @default.
- W4226109959 cites W2793965282 @default.
- W4226109959 cites W2794820058 @default.
- W4226109959 cites W2806425638 @default.
- W4226109959 cites W2806548054 @default.
- W4226109959 cites W2808421356 @default.
- W4226109959 cites W2810097927 @default.
- W4226109959 cites W2865352686 @default.
- W4226109959 cites W2883592521 @default.
- W4226109959 cites W2886248543 @default.
- W4226109959 cites W2891125665 @default.
- W4226109959 cites W2894795605 @default.
- W4226109959 cites W2898415660 @default.
- W4226109959 cites W2898806520 @default.
- W4226109959 cites W2901515128 @default.
- W4226109959 cites W2901738572 @default.
- W4226109959 cites W2902059429 @default.
- W4226109959 cites W2902964933 @default.
- W4226109959 cites W2904827199 @default.
- W4226109959 cites W2912390237 @default.
- W4226109959 cites W2916020270 @default.
- W4226109959 cites W2927575800 @default.
- W4226109959 cites W2937667996 @default.
- W4226109959 cites W2947548345 @default.
- W4226109959 cites W2949177718 @default.
- W4226109959 cites W2955352229 @default.
- W4226109959 cites W2970250038 @default.
- W4226109959 cites W2971867169 @default.
- W4226109959 cites W3005803699 @default.
- W4226109959 cites W3006308011 @default.
- W4226109959 cites W3012351699 @default.
- W4226109959 cites W3015646919 @default.
- W4226109959 cites W3022464154 @default.
- W4226109959 cites W3035653505 @default.
- W4226109959 cites W3038026221 @default.
- W4226109959 cites W3041851038 @default.
- W4226109959 cites W3045872583 @default.
- W4226109959 cites W3086700213 @default.
- W4226109959 cites W3089191828 @default.