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• W4226134083 endingPage "201" @default.
• W4226134083 startingPage "153" @default.
• W4226134083 abstract "The EPH receptor tyrosine kinases and their signaling partners, the EPHRINS, comprise a large class of cell signaling molecules that plays diverse roles in development. As cell membrane-anchored signaling molecules, they regulate cellular organization by modulating the strength of cellular contacts, usually by impacting the actin cytoskeleton or cell adhesion programs. Through these cellular functions, EPH/EPHRIN signaling often regulates tissue shape. Indeed, recent evidence indicates that this signaling family is ancient and associated with the origin of multicellularity. Though extensively studied, our understanding of the signaling mechanisms employed by this large family of signaling proteins remains patchwork, and a truly canonical EPH/EPHRIN signal transduction pathway is not known and may not exist. Instead, several foundational evolutionarily conserved mechanisms are overlaid by a myriad of tissue -specific functions, though common themes emerge from these as well. Here, I review recent advances and the related contexts that have provided new understanding of the conserved and varied molecular and cellular mechanisms employed by EPH/EPHRIN signaling during development." @default.
• W4226134083 created "2022-05-05" @default.
• W4226134083 creator A5002837885 @default.
• W4226134083 date "2022-01-01" @default.
• W4226134083 modified "2023-09-23" @default.
• W4226134083 title "Cellular and molecular mechanisms of EPH/EPHRIN signaling in evolution and development" @default.
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