Matches in SemOpenAlex for { <https://semopenalex.org/work/W4226136002> ?p ?o ?g. }
- W4226136002 endingPage "325" @default.
- W4226136002 startingPage "309" @default.
- W4226136002 abstract "One hundred fifty yolk sac tumors (YSTs) of the ovary in patients from 1 to 61 (mean: 21.5) years of age are described; 75% of the patients were in the second and third decades and only 1 was above 50 years of age. The clinical manifestations were typically related to a fast-growing adnexal mass; endocrine manifestations (hirsutism) were present in only 2 cases. The tumors were all unilateral and 70% were ≥15 cm; an associated dermoid cyst was present in 20 cases. The tumors were solid and cystic in 57% of the cases, 25% were multicystic, and 18% uniformly solid. The solid tissue was typically tan to pink or yellow and often friable with hemorrhage and necrosis; smaller solid neoplasms were sometime uniformly yellow. The most common histologic pattern was reticular composed of an irregular meshwork of spaces that was conspicuous in 68% of the neoplasms but present to at least a minor degree in all of them. That appearance almost always merged with small to large cysts that were prominent in about 40% of tumors. In 25% of the tumors, cysts sometimes associated with a cellular stroma (the polyvesicular pattern), were present but conspicuous in only half these cases. One third of the tumors had a labyrinthine pattern, 22% glands, and 6% a festoon pattern. Papillae with a central blood vessel (Schiller-Duval bodies) were seen in one-third of the tumors but were numerous in only 5% of them. Nonspecific appearing papillae were seen in 10% of the tumors. A solid growth of cells with pale cytoplasm was seen in one-third of the tumors but was conspicuous in only half of that subset. The solid appearance was typically reminiscent of that of dysgerminoma, but lacked the septa and lymphocytic infiltrate of that neoplasm. Nine tumors had a component of cells with scant cytoplasm resulting in a blastema-like appearance and 3 had cells with abundant clear cytoplasm. Cords and clusters of cells were common but did not dominate the microscopic appearance. The stroma typically had a nonspecific collagenous to edematous appearance. Stromal luteinization was seen in 12 tumors; in 5 this was likely due to the patient being pregnant. Two tumors had minor foci of cells that resembled hepatocytes. Hyaline bodies were seen in most of the tumors and were often conspicuous. The neoplastic cells typically had modest amounts of lightly staining cytoplasm and only mild nuclear pleomorphism. Cells lining cysts were often flattened sometimes resulting in a deceptively innocuous appearance. Many of the tumors (mostly consultation cases), caused diagnostic difficulty; tumors in the differential diagnosis included clear cell carcinoma, embryonal carcinoma, Sertoli-Leydig cell tumor, and juvenile granulosa cell tumor. The patient age and marked elevation of the serum alpha-fetoprotein level (if measured) is helpful in many of these considerations. The overtly malignant gross appearance of most YSTs contrasts with certain other tumors in the differential and the association of some YSTs with dermoid cyst and many clear cell carcinomas with endometriosis may be helpful. The vast majority of ovarian YSTs are dominated microscopically by merging of reticular and cystic patterns which, although focally mimicked by other neoplasms, are in general characteristic, and distinctive features of other neoplasms are absent. Immunohistochemistry, particularly for alpha-fetoprotein and glypican 3, and lack of staining for various markers of other neoplasms is helpful but overlap exists and these results must be considered in the context of the overall clinical, gross, and microscopic features. YSTs dominated by hepatoid and glandular features are rare and their categorization as YSTs should be done cautiously if thoroughly sampled tumors show no evidence of classic features of YST emphasized herein and first elaborated by the Danish investigator Gunnar Teilum whose seminal observations have stood the test of time." @default.
- W4226136002 created "2022-05-05" @default.
- W4226136002 creator A5047687139 @default.
- W4226136002 creator A5063558415 @default.
- W4226136002 creator A5069885975 @default.
- W4226136002 date "2021-08-30" @default.
- W4226136002 modified "2023-10-16" @default.
- W4226136002 title "Yolk Sac Tumor of the Ovary" @default.
- W4226136002 cites W1511441981 @default.
- W4226136002 cites W1575058439 @default.
- W4226136002 cites W181409 @default.
- W4226136002 cites W1914326941 @default.
- W4226136002 cites W1966452163 @default.
- W4226136002 cites W1970221300 @default.
- W4226136002 cites W1972232254 @default.
- W4226136002 cites W1972482349 @default.
- W4226136002 cites W1974571552 @default.
- W4226136002 cites W1975285884 @default.
- W4226136002 cites W1976048583 @default.
- W4226136002 cites W1978002176 @default.
- W4226136002 cites W1978748242 @default.
- W4226136002 cites W1981516609 @default.
- W4226136002 cites W1986891431 @default.
- W4226136002 cites W1987508362 @default.
- W4226136002 cites W1995833230 @default.
- W4226136002 cites W1998554304 @default.
- W4226136002 cites W2003189167 @default.
- W4226136002 cites W2014246282 @default.
- W4226136002 cites W2015996838 @default.
- W4226136002 cites W2017904672 @default.
- W4226136002 cites W2029494363 @default.
- W4226136002 cites W2031858219 @default.
- W4226136002 cites W2035223930 @default.
- W4226136002 cites W2036315508 @default.
- W4226136002 cites W2039268307 @default.
- W4226136002 cites W2041726447 @default.
- W4226136002 cites W2043713584 @default.
- W4226136002 cites W2044057956 @default.
- W4226136002 cites W2051968334 @default.
- W4226136002 cites W2056665540 @default.
- W4226136002 cites W2057191364 @default.
- W4226136002 cites W2060165317 @default.
- W4226136002 cites W2060883842 @default.
- W4226136002 cites W2062478826 @default.
- W4226136002 cites W2064695540 @default.
- W4226136002 cites W2071192806 @default.
- W4226136002 cites W2079366546 @default.
- W4226136002 cites W2084242426 @default.
- W4226136002 cites W2086228440 @default.
- W4226136002 cites W2089967916 @default.
- W4226136002 cites W2094789868 @default.
- W4226136002 cites W2094795672 @default.
- W4226136002 cites W2095647436 @default.
- W4226136002 cites W2098301455 @default.
- W4226136002 cites W2106241360 @default.
- W4226136002 cites W2120734014 @default.
- W4226136002 cites W2152634619 @default.
- W4226136002 cites W2158579685 @default.
- W4226136002 cites W2315093245 @default.
- W4226136002 cites W2319029548 @default.
- W4226136002 cites W2329443781 @default.
- W4226136002 cites W2329999734 @default.
- W4226136002 cites W2472939533 @default.
- W4226136002 cites W2605598385 @default.
- W4226136002 cites W2620836569 @default.
- W4226136002 cites W2745989101 @default.
- W4226136002 cites W2767852617 @default.
- W4226136002 cites W2897207534 @default.
- W4226136002 cites W2933059043 @default.
- W4226136002 cites W2939688148 @default.
- W4226136002 cites W3036049087 @default.
- W4226136002 cites W3111011361 @default.
- W4226136002 cites W3128119372 @default.
- W4226136002 cites W4296116471 @default.
- W4226136002 doi "https://doi.org/10.1097/pas.0000000000001793" @default.
- W4226136002 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34469331" @default.
- W4226136002 hasPublicationYear "2021" @default.
- W4226136002 type Work @default.
- W4226136002 citedByCount "4" @default.
- W4226136002 countsByYear W42261360022022 @default.
- W4226136002 countsByYear W42261360022023 @default.
- W4226136002 crossrefType "journal-article" @default.
- W4226136002 hasAuthorship W4226136002A5047687139 @default.
- W4226136002 hasAuthorship W4226136002A5063558415 @default.
- W4226136002 hasAuthorship W4226136002A5069885975 @default.
- W4226136002 hasConcept C105702510 @default.
- W4226136002 hasConcept C134018914 @default.
- W4226136002 hasConcept C142724271 @default.
- W4226136002 hasConcept C196843134 @default.
- W4226136002 hasConcept C204232928 @default.
- W4226136002 hasConcept C2777043721 @default.
- W4226136002 hasConcept C2778324911 @default.
- W4226136002 hasConcept C2780597408 @default.
- W4226136002 hasConcept C52124034 @default.
- W4226136002 hasConcept C71924100 @default.
- W4226136002 hasConcept C86803240 @default.
- W4226136002 hasConcept C95190701 @default.
- W4226136002 hasConcept C95444343 @default.