FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4226137924> ?p ?o ?g. }

• W4226137924 abstract "Although extensive use of antiretroviral therapy (ART) has made great progress in controlling HIV replication and improving CD4+ T cell recovery, the immune reconstitution remained insufficient in some patients, who were defined as poor immunological responders (PIRs). These PIRs were at a high risk of AIDS-related and non-AIDS complications, resulting in higher morbidity and mortality rate. Thus, it is a major challenge and urgently needed to distinguish PIRs early and improve their immune function in time. Immune activation is a key factor that leads to impaired immune reconstitution in people living with HIV (PLWH) who are receiving effective ART. Double negative T cells (DNT) were reported to associate with the control of immune activation during HIV infection. However, the precise mechanisms by which DNT cells exerted their suppressive capacity during HIV infection remained puzzled. CD73, both a soluble and a membrane-bound form, display immunosuppressive effects through producing adenosine (ADO). Thus, whether DNT cells expressed CD73 and mediated immune suppression through CD73-ADO pathway needs to be investigated. Here, we found a significant downregulation of CD73 expression on DNT cells in treatment-naïve PLWH (TNs) compared to healthy controls, accompanied with increased concentration of sCD73 in plasma. Both the frequency of CD73+ DNT cells and the level of plasma sCD73 recovered after ART treatment. However, PIRs showed decreased percentage of CD73+ DNT cells compared to immunological responders (IRs). The frequency of CD73+ DNT cells was positively correlated with CD4+ T cell count and CD4/CD8 ratio, and negatively correlated with immune activation in PLWH. The level of sCD73 also showed a negative correlation to CD4+ T cell count and CD4/CD8 ratio. More importantly, in the present cohort, a higher level of sCD73 at the time of initiating ART could predict poor immune reconstitution in PLWH after long-term ART. Our findings highlighted the importance of CD73+ DNT cells and sCD73 in the disease progression and immune reconstitution of PLWH, and provided evidences for sCD73 as a potential biomarker of predicting immune recovery." @default.
• W4226137924 created "2022-05-05" @default.
• W4226137924 creator A5001714299 @default.
• W4226137924 creator A5002616979 @default.
• W4226137924 creator A5004140817 @default.
• W4226137924 creator A5007728076 @default.
• W4226137924 creator A5023494462 @default.
• W4226137924 creator A5027130695 @default.
• W4226137924 creator A5029574705 @default.
• W4226137924 creator A5041479429 @default.
• W4226137924 creator A5047589359 @default.
• W4226137924 creator A5052304130 @default.
• W4226137924 creator A5056496295 @default.
• W4226137924 creator A5081085876 @default.
• W4226137924 date "2022-04-04" @default.
• W4226137924 modified "2023-09-25" @default.
• W4226137924 title "Decreased CD73+ Double-Negative T Cells and Elevated Level of Soluble CD73 Correlated With and Predicted Poor Immune Reconstitution in HIV-Infected Patients After Antiretroviral Therapy" @default.
• W4226137924 cites W1507917955 @default.
• W4226137924 cites W1967974256 @default.
• W4226137924 cites W1974409640 @default.
• W4226137924 cites W1976882223 @default.
• W4226137924 cites W1995858393 @default.
• W4226137924 cites W1996511424 @default.
• W4226137924 cites W1998353416 @default.
• W4226137924 cites W2003422391 @default.
• W4226137924 cites W2009116479 @default.
• W4226137924 cites W2011030259 @default.
• W4226137924 cites W2027063158 @default.
• W4226137924 cites W2031283370 @default.
• W4226137924 cites W2033172239 @default.
• W4226137924 cites W2037081974 @default.
• W4226137924 cites W2038797605 @default.
• W4226137924 cites W2053252472 @default.
• W4226137924 cites W2065573353 @default.
• W4226137924 cites W2074659126 @default.
• W4226137924 cites W2086241566 @default.
• W4226137924 cites W2086556660 @default.
• W4226137924 cites W2087092404 @default.
• W4226137924 cites W2091815611 @default.
• W4226137924 cites W2095050873 @default.
• W4226137924 cites W2096081051 @default.
• W4226137924 cites W2097292233 @default.
• W4226137924 cites W2100903133 @default.
• W4226137924 cites W2115184655 @default.
• W4226137924 cites W2117200807 @default.
• W4226137924 cites W2131842611 @default.
• W4226137924 cites W2132567665 @default.
• W4226137924 cites W2138694347 @default.
• W4226137924 cites W2141465448 @default.
• W4226137924 cites W2153092839 @default.
• W4226137924 cites W2155651193 @default.
• W4226137924 cites W2155653612 @default.
• W4226137924 cites W2156020711 @default.
• W4226137924 cites W2157444253 @default.
• W4226137924 cites W2162883643 @default.
• W4226137924 cites W2162946230 @default.
• W4226137924 cites W2318478172 @default.
• W4226137924 cites W2320151632 @default.
• W4226137924 cites W2398244149 @default.
• W4226137924 cites W2402741651 @default.
• W4226137924 cites W2403903608 @default.
• W4226137924 cites W2534110833 @default.
• W4226137924 cites W2559983598 @default.
• W4226137924 cites W2567643666 @default.
• W4226137924 cites W2588330184 @default.
• W4226137924 cites W2620136843 @default.
• W4226137924 cites W2788122721 @default.
• W4226137924 cites W2793901723 @default.
• W4226137924 cites W2898132987 @default.
• W4226137924 cites W2898178240 @default.
• W4226137924 cites W2904184497 @default.
• W4226137924 cites W2911465813 @default.
• W4226137924 cites W2911862132 @default.
• W4226137924 cites W2913753851 @default.
• W4226137924 cites W2914834573 @default.
• W4226137924 cites W2923552871 @default.
• W4226137924 cites W2945250975 @default.
• W4226137924 cites W2945612803 @default.
• W4226137924 cites W2960437015 @default.
• W4226137924 cites W2965479901 @default.
• W4226137924 cites W2968552908 @default.
• W4226137924 cites W2971169687 @default.
• W4226137924 cites W2981793542 @default.
• W4226137924 cites W2990110232 @default.
• W4226137924 cites W3001393750 @default.
• W4226137924 cites W3008504135 @default.
• W4226137924 cites W3015878386 @default.
• W4226137924 cites W3044609350 @default.
• W4226137924 cites W3045589411 @default.
• W4226137924 cites W3047617082 @default.
• W4226137924 cites W3089099444 @default.
• W4226137924 cites W3110674904 @default.
• W4226137924 cites W3116810251 @default.
• W4226137924 cites W3129815729 @default.
• W4226137924 cites W3130124799 @default.
• W4226137924 cites W3166260715 @default.
• W4226137924 cites W3184124949 @default.
• W4226137924 cites W3193450770 @default.
• W4226137924 cites W3201817149 @default.
• W4226137924 cites W3202858575 @default.

• next