Matches in SemOpenAlex for { <https://semopenalex.org/work/W4226143248> ?p ?o ?g. }
- W4226143248 abstract "Diabetic retinopathy is a prototypical microvascular disorder. Hyperglycemia causes a multiple pathological changes in the retinal vasculature. It has been suggested that apoptosis of pericytes due to high glucose levels plays a key role in the development of the earliest events during diabetic retinopathy. Advancement of the disease resulted in a progressive vessel leakage leading to edematous distortion of macula and increase in hypoxia inducing development of neovascularization with sight threatening complications. Four basis hypotheses explaining the hyperglycemia harmful effects were suggested: (1) increased glucose flux through the aldose reductase pathway, (2) overproduction of advanced glycation end products, (3) activation of protein kinase C isoforms, and (4) increased glucose flux via the hexosamine pathway. It was admitted as well that apoptosis of neurons and glial cell activation occur even earlier than vascular damage. Disturbance in glial cell functions leads to increase in metabolic abnormalities such as glutamate accumulation, promotion of inflammation, and oxidative stress resulting in neuron apoptosis and deterioration of vascular disorders. Clarification of significant biochemical mechanisms involving in the development of diabetic retinopathy can help to create new effective ways in diabetic retinopathy treatment." @default.
- W4226143248 created "2022-05-05" @default.
- W4226143248 creator A5008540937 @default.
- W4226143248 date "2022-04-06" @default.
- W4226143248 modified "2023-09-26" @default.
- W4226143248 title "Pathophysiology of Diabetic Retinopathy" @default.
- W4226143248 cites W164884231 @default.
- W4226143248 cites W1783580437 @default.
- W4226143248 cites W1968352279 @default.
- W4226143248 cites W1969536547 @default.
- W4226143248 cites W1971104032 @default.
- W4226143248 cites W1971255749 @default.
- W4226143248 cites W1971853219 @default.
- W4226143248 cites W1975028551 @default.
- W4226143248 cites W1976442335 @default.
- W4226143248 cites W1982852850 @default.
- W4226143248 cites W1988917398 @default.
- W4226143248 cites W1990243165 @default.
- W4226143248 cites W1993503963 @default.
- W4226143248 cites W1993721436 @default.
- W4226143248 cites W1993968665 @default.
- W4226143248 cites W1996337164 @default.
- W4226143248 cites W1997245401 @default.
- W4226143248 cites W1998606727 @default.
- W4226143248 cites W1999688174 @default.
- W4226143248 cites W1999745906 @default.
- W4226143248 cites W2014829681 @default.
- W4226143248 cites W2020554150 @default.
- W4226143248 cites W2021338387 @default.
- W4226143248 cites W2024206845 @default.
- W4226143248 cites W2026703782 @default.
- W4226143248 cites W2030895970 @default.
- W4226143248 cites W2031503758 @default.
- W4226143248 cites W2031740343 @default.
- W4226143248 cites W2039017984 @default.
- W4226143248 cites W2042550512 @default.
- W4226143248 cites W2043406584 @default.
- W4226143248 cites W2046433337 @default.
- W4226143248 cites W2047094134 @default.
- W4226143248 cites W2047956321 @default.
- W4226143248 cites W2055484170 @default.
- W4226143248 cites W2057328170 @default.
- W4226143248 cites W2059921071 @default.
- W4226143248 cites W2064710522 @default.
- W4226143248 cites W2064836014 @default.
- W4226143248 cites W2066290187 @default.
- W4226143248 cites W2067514854 @default.
- W4226143248 cites W2072457325 @default.
- W4226143248 cites W2073080713 @default.
- W4226143248 cites W2073290778 @default.
- W4226143248 cites W2073296546 @default.
- W4226143248 cites W2073826444 @default.
- W4226143248 cites W2074639523 @default.
- W4226143248 cites W2075553837 @default.
- W4226143248 cites W2077726387 @default.
- W4226143248 cites W2080627917 @default.
- W4226143248 cites W2082730029 @default.
- W4226143248 cites W2086256951 @default.
- W4226143248 cites W2086524338 @default.
- W4226143248 cites W2087899702 @default.
- W4226143248 cites W2091804586 @default.
- W4226143248 cites W2094233549 @default.
- W4226143248 cites W2102348049 @default.
- W4226143248 cites W2102665979 @default.
- W4226143248 cites W2108337314 @default.
- W4226143248 cites W2111867309 @default.
- W4226143248 cites W2116709740 @default.
- W4226143248 cites W2117568221 @default.
- W4226143248 cites W2118387029 @default.
- W4226143248 cites W2124149196 @default.
- W4226143248 cites W2124751311 @default.
- W4226143248 cites W2125014313 @default.
- W4226143248 cites W2127963035 @default.
- W4226143248 cites W2128640792 @default.
- W4226143248 cites W2142007424 @default.
- W4226143248 cites W2147457499 @default.
- W4226143248 cites W2149342137 @default.
- W4226143248 cites W2149372275 @default.
- W4226143248 cites W2150180275 @default.
- W4226143248 cites W2154228322 @default.
- W4226143248 cites W2155295568 @default.
- W4226143248 cites W2156849498 @default.
- W4226143248 cites W2159891170 @default.
- W4226143248 cites W2160907352 @default.
- W4226143248 cites W2169298067 @default.
- W4226143248 cites W2172356054 @default.
- W4226143248 cites W2198544205 @default.
- W4226143248 cites W2250017028 @default.
- W4226143248 cites W2298712327 @default.
- W4226143248 cites W2313838053 @default.
- W4226143248 cites W2346484181 @default.
- W4226143248 cites W2750410498 @default.
- W4226143248 cites W2809489644 @default.
- W4226143248 cites W2883798682 @default.
- W4226143248 cites W2979622486 @default.
- W4226143248 cites W2980652609 @default.
- W4226143248 cites W3087235483 @default.
- W4226143248 cites W4232828526 @default.
- W4226143248 cites W4235630558 @default.
- W4226143248 cites W4236050547 @default.