Matches in SemOpenAlex for { <https://semopenalex.org/work/W4226147122> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W4226147122 abstract "Abstract Introduction residents of long-term care facilities (LTCFs) are at high risk of adverse outcomes from SARS-CoV-2. We aimed to estimate the vaccine effectiveness (VE) of one and two doses of BNT162b2 and ChAdOx-1 against SARS CoV-2 infection and COVID-19-related death in residents of LTCFs. Methods this observational study used testing, vaccination and mortality data for LTCF residents aged ≥ 65 years who were regularly tested regardless of symptoms from 8 December 2020 to 30 September 2021 in England. Adjusted VE, calculated as one minus adjusted hazard ratio, was estimated using time-varying Cox proportional hazards models for infection and death within 28 days of positive test result. Vaccine status was defined by receipt of one or two doses of vaccine and assessed over a range of intervals. Results of 197,885 LTCF residents, 47,087 (23.8%) had a positive test and 11,329 (5.8%) died within 28 days of a positive test during the study period. Relative to unvaccinated individuals, VE for infection was highest for ChAdOx-1 at 61% (40–74%) at 1–4 weeks and for BNT162b2 at 69% (52–80%) at 11–15 weeks following the second dose. Against death, VE was highest for ChAdOx-1 at 83% (58–94%) at 1–4 weeks and for BNT162b2 at 91% (75–97%) at 11–15 weeks following second dose. Conclusions compared with unvaccinated residents, vaccination with one dose of BNT162b2 or ChAdOx-1 provided moderate protection against infection and death in residents of LTCFs. Protection against death improved after two doses. However, some waning of protection over time was noted." @default.
- W4226147122 created "2022-05-05" @default.
- W4226147122 creator A5029944065 @default.
- W4226147122 creator A5038691513 @default.
- W4226147122 creator A5039036533 @default.
- W4226147122 creator A5051037765 @default.
- W4226147122 creator A5052449898 @default.
- W4226147122 creator A5063780388 @default.
- W4226147122 creator A5072485453 @default.
- W4226147122 creator A5074707067 @default.
- W4226147122 date "2022-05-01" @default.
- W4226147122 modified "2023-09-26" @default.
- W4226147122 title "Effectiveness of BNT162b2 and ChAdOx-1 vaccines in residents of long-term care facilities in England using a time-varying proportional hazards model" @default.
- W4226147122 cites W2119964825 @default.
- W4226147122 cites W3042833857 @default.
- W4226147122 cites W3111255098 @default.
- W4226147122 cites W3158276912 @default.
- W4226147122 cites W3160138987 @default.
- W4226147122 cites W3166524079 @default.
- W4226147122 cites W3167745226 @default.
- W4226147122 cites W3174534250 @default.
- W4226147122 cites W3178337677 @default.
- W4226147122 cites W3184226105 @default.
- W4226147122 cites W3214652073 @default.
- W4226147122 cites W4226054307 @default.
- W4226147122 doi "https://doi.org/10.1093/ageing/afac115" @default.
- W4226147122 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35596946" @default.
- W4226147122 hasPublicationYear "2022" @default.
- W4226147122 type Work @default.
- W4226147122 citedByCount "5" @default.
- W4226147122 countsByYear W42261471222022 @default.
- W4226147122 countsByYear W42261471222023 @default.
- W4226147122 crossrefType "journal-article" @default.
- W4226147122 hasAuthorship W4226147122A5029944065 @default.
- W4226147122 hasAuthorship W4226147122A5038691513 @default.
- W4226147122 hasAuthorship W4226147122A5039036533 @default.
- W4226147122 hasAuthorship W4226147122A5051037765 @default.
- W4226147122 hasAuthorship W4226147122A5052449898 @default.
- W4226147122 hasAuthorship W4226147122A5063780388 @default.
- W4226147122 hasAuthorship W4226147122A5072485453 @default.
- W4226147122 hasAuthorship W4226147122A5074707067 @default.
- W4226147122 hasBestOaLocation W42261471221 @default.
- W4226147122 hasConcept C126322002 @default.
- W4226147122 hasConcept C159110408 @default.
- W4226147122 hasConcept C194828623 @default.
- W4226147122 hasConcept C203014093 @default.
- W4226147122 hasConcept C207103383 @default.
- W4226147122 hasConcept C22070199 @default.
- W4226147122 hasConcept C23131810 @default.
- W4226147122 hasConcept C2779134260 @default.
- W4226147122 hasConcept C2780233487 @default.
- W4226147122 hasConcept C3008058167 @default.
- W4226147122 hasConcept C44249647 @default.
- W4226147122 hasConcept C50382708 @default.
- W4226147122 hasConcept C524204448 @default.
- W4226147122 hasConcept C71924100 @default.
- W4226147122 hasConceptScore W4226147122C126322002 @default.
- W4226147122 hasConceptScore W4226147122C159110408 @default.
- W4226147122 hasConceptScore W4226147122C194828623 @default.
- W4226147122 hasConceptScore W4226147122C203014093 @default.
- W4226147122 hasConceptScore W4226147122C207103383 @default.
- W4226147122 hasConceptScore W4226147122C22070199 @default.
- W4226147122 hasConceptScore W4226147122C23131810 @default.
- W4226147122 hasConceptScore W4226147122C2779134260 @default.
- W4226147122 hasConceptScore W4226147122C2780233487 @default.
- W4226147122 hasConceptScore W4226147122C3008058167 @default.
- W4226147122 hasConceptScore W4226147122C44249647 @default.
- W4226147122 hasConceptScore W4226147122C50382708 @default.
- W4226147122 hasConceptScore W4226147122C524204448 @default.
- W4226147122 hasConceptScore W4226147122C71924100 @default.
- W4226147122 hasIssue "5" @default.
- W4226147122 hasLocation W42261471221 @default.
- W4226147122 hasLocation W42261471222 @default.
- W4226147122 hasLocation W42261471223 @default.
- W4226147122 hasOpenAccess W4226147122 @default.
- W4226147122 hasPrimaryLocation W42261471221 @default.
- W4226147122 hasRelatedWork W2410078100 @default.
- W4226147122 hasRelatedWork W2765980456 @default.
- W4226147122 hasRelatedWork W2976382042 @default.
- W4226147122 hasRelatedWork W2986927582 @default.
- W4226147122 hasRelatedWork W2994686985 @default.
- W4226147122 hasRelatedWork W3010379971 @default.
- W4226147122 hasRelatedWork W3112727085 @default.
- W4226147122 hasRelatedWork W3181290183 @default.
- W4226147122 hasRelatedWork W3217408445 @default.
- W4226147122 hasRelatedWork W4383817509 @default.
- W4226147122 hasVolume "51" @default.
- W4226147122 isParatext "false" @default.
- W4226147122 isRetracted "false" @default.
- W4226147122 workType "article" @default.