Matches in SemOpenAlex for { <https://semopenalex.org/work/W4226148914> ?p ?o ?g. }
- W4226148914 abstract "The transient receptor potential melastatin-subfamily member 7 (TRPM7) is a ubiquitously expressed membrane protein consisting of ion channel and protein kinase domains. TRPM7 plays a fundamental role in the cellular uptake of divalent cations such as Zn2+, Mg2+, and Ca2+, and thus shapes cellular excitability, plasticity, and metabolic activity. The molecular appearance and operation of TRPM7 channels in native tissues have remained unresolved. Here, we investigated the subunit composition of endogenous TRPM7 channels in rodent brain by multi-epitope affinity purification and high-resolution quantitative mass spectrometry (MS) analysis. We found that native TRPM7 channels are high-molecular-weight multi-protein complexes that contain the putative metal transporter proteins CNNM1-4 and a small G-protein ADP-ribosylation factor-like protein 15 (ARL15). Heterologous reconstitution experiments confirmed the formation of TRPM7/CNNM/ARL15 ternary complexes and indicated that complex formation effectively and specifically impacts TRPM7 activity. These results open up new avenues towards a mechanistic understanding of the cellular regulation and function of TRPM7 channels." @default.
- W4226148914 created "2022-05-05" @default.
- W4226148914 creator A5004526076 @default.
- W4226148914 creator A5014009136 @default.
- W4226148914 creator A5016255269 @default.
- W4226148914 creator A5026172623 @default.
- W4226148914 creator A5031032546 @default.
- W4226148914 creator A5032679885 @default.
- W4226148914 creator A5038815461 @default.
- W4226148914 creator A5051096774 @default.
- W4226148914 creator A5054211669 @default.
- W4226148914 creator A5058494902 @default.
- W4226148914 creator A5063041643 @default.
- W4226148914 creator A5065854689 @default.
- W4226148914 creator A5083310937 @default.
- W4226148914 creator A5084716908 @default.
- W4226148914 date "2021-11-12" @default.
- W4226148914 modified "2023-10-14" @default.
- W4226148914 title "The molecular appearance of native TRPM7 channel complexes identified by high-resolution proteomics" @default.
- W4226148914 cites W1559892880 @default.
- W4226148914 cites W1970119870 @default.
- W4226148914 cites W1970899379 @default.
- W4226148914 cites W1974956422 @default.
- W4226148914 cites W1981187805 @default.
- W4226148914 cites W1997808089 @default.
- W4226148914 cites W1997905862 @default.
- W4226148914 cites W2004277471 @default.
- W4226148914 cites W2016855276 @default.
- W4226148914 cites W2017326015 @default.
- W4226148914 cites W2022121838 @default.
- W4226148914 cites W2022645001 @default.
- W4226148914 cites W2025655555 @default.
- W4226148914 cites W2031972450 @default.
- W4226148914 cites W2033576768 @default.
- W4226148914 cites W2044517704 @default.
- W4226148914 cites W2058096544 @default.
- W4226148914 cites W2063062496 @default.
- W4226148914 cites W2066581734 @default.
- W4226148914 cites W2077131862 @default.
- W4226148914 cites W2078712719 @default.
- W4226148914 cites W2079172441 @default.
- W4226148914 cites W2081286585 @default.
- W4226148914 cites W2081465448 @default.
- W4226148914 cites W2087668761 @default.
- W4226148914 cites W2093870407 @default.
- W4226148914 cites W2096972525 @default.
- W4226148914 cites W2097463865 @default.
- W4226148914 cites W2102025441 @default.
- W4226148914 cites W2105027622 @default.
- W4226148914 cites W2123347941 @default.
- W4226148914 cites W2126283502 @default.
- W4226148914 cites W2127432085 @default.
- W4226148914 cites W2134913638 @default.
- W4226148914 cites W2137284096 @default.
- W4226148914 cites W2151512622 @default.
- W4226148914 cites W2155217644 @default.
- W4226148914 cites W2156783552 @default.
- W4226148914 cites W2158861376 @default.
- W4226148914 cites W2166073081 @default.
- W4226148914 cites W2255970755 @default.
- W4226148914 cites W2272200006 @default.
- W4226148914 cites W2294346876 @default.
- W4226148914 cites W2313039228 @default.
- W4226148914 cites W2554085235 @default.
- W4226148914 cites W2559646639 @default.
- W4226148914 cites W2564271594 @default.
- W4226148914 cites W2581018228 @default.
- W4226148914 cites W2584060755 @default.
- W4226148914 cites W2590202763 @default.
- W4226148914 cites W2593034715 @default.
- W4226148914 cites W2616561032 @default.
- W4226148914 cites W2734897374 @default.
- W4226148914 cites W2749306122 @default.
- W4226148914 cites W2766622315 @default.
- W4226148914 cites W2766635905 @default.
- W4226148914 cites W2767214141 @default.
- W4226148914 cites W2768099675 @default.
- W4226148914 cites W2792060787 @default.
- W4226148914 cites W2809367045 @default.
- W4226148914 cites W2885142817 @default.
- W4226148914 cites W2901147052 @default.
- W4226148914 cites W2911908266 @default.
- W4226148914 cites W2919341931 @default.
- W4226148914 cites W2947268131 @default.
- W4226148914 cites W2980519948 @default.
- W4226148914 cites W2994671969 @default.
- W4226148914 cites W3127653892 @default.
- W4226148914 cites W3157357317 @default.
- W4226148914 cites W3176054038 @default.
- W4226148914 cites W3193935362 @default.
- W4226148914 cites W3202195052 @default.
- W4226148914 cites W4233897684 @default.
- W4226148914 doi "https://doi.org/10.7554/elife.68544" @default.
- W4226148914 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34766907" @default.
- W4226148914 hasPublicationYear "2021" @default.
- W4226148914 type Work @default.
- W4226148914 citedByCount "24" @default.
- W4226148914 countsByYear W42261489142021 @default.
- W4226148914 countsByYear W42261489142022 @default.
- W4226148914 countsByYear W42261489142023 @default.