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- W4226156935 endingPage "e365" @default.
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- W4226156935 abstract "We review the literature on the efficacy and safety outcomes of secondary Descemet stripping endothelial keratoplasty (DSEK) and Descemet membrane endothelial keratoplasty (DMEK).Literature search of English-written publications up to September 27, 2020 in PubMed database, using the terms endothelial keratoplasty in combination with keywords secondary or repeat. In addition, we manually searched the references of the primary articles.Twenty-seven studies (n = 651 eyes) were retained and reviewed, including 10 studies on repeat DSEK, 8 studies on repeat DMEK, 6 studies of DMEK following DSEK, and 3 studies of DSEK after failed DMEK. All studies reported significant improvement in visual acuity after secondary endothelial keratoplasty (EK). Twelve studies compared visual outcomes between primary and secondary EK, reporting conflicting findings. Sixteen studies reported endothelial cell loss rates after secondary EK, and only 1 study reported significantly increased endothelial cell loss rates compared with primary EK. Allograft rejection episodes occurred in 1.8% of eyes (range, 0%-50%). Six studies compared complication rates between primary and secondary EK eyes, and only 1 study found a higher median number of complications. However, 2 studies reported higher regraft failure rates compared with primary EK eyes.Secondary EK is surgically feasible and renders significant visual improvement after failed primary EK, although it is not clear whether visual outcomes and allograft survival are comparable with primary EK, raising the question of whether secondary EK eyes are low risk as primary EK eyes. Further larger, prospective studies are encouraged to obtain additional quality data on secondary corneal endothelial allotransplantation." @default.
- W4226156935 created "2022-05-05" @default.
- W4226156935 creator A5053947328 @default.
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- W4226156935 creator A5081130984 @default.
- W4226156935 creator A5081269725 @default.
- W4226156935 creator A5088021535 @default.
- W4226156935 date "2021-03-04" @default.
- W4226156935 modified "2023-10-04" @default.
- W4226156935 title "Secondary Endothelial Keratoplasty—A Narrative Review of the Outcomes of Secondary Corneal Endothelial Allografts" @default.
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