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- W4226159970 abstract "This study examined if isoliquiritigenin (ISL) attenuates high-fat diet (HFD)-induced intestinal damage and if this involves modulating Nrf2. Rats included 5 groups (n = 8/group): control (vehicle), ISL, HFD, HFD + ISL, and HFD + ISL + brusatol (an inhibitor of Nrf2). Treatments with the vehicle and ISL (30 mg/kg) were given orally. With no effect on intestinal lipids, ISL improved the duodenal structure in HFD rats and reduced the duodenal levels of malondialdehyde, tumor necrosis factor-α, interleukin-6, macrophage chemoattractant protein-1, and nuclear levels of NF-κB p65. Also, ISL increased the intestinal levels of superoxide dismutase, catalase, glutathione, and the cytoplasmic and nuclear levels of Nrf2. Furthermore, ISL lowered circulatory levels of lipopolysaccharides, deactivated the myosin light chain kinase (MLCK), and increased mRNA claudin-1, occluding, and zonula occludens‑1. All these effects were prevented by co-treatment of brusatol. In conclusion, ISL is a potent activator of Nrf2 intestinal inflammatory disorders." @default.
- W4226159970 created "2022-05-05" @default.
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- W4226159970 date "2022-05-01" @default.
- W4226159970 modified "2023-09-26" @default.
- W4226159970 title "Isoliquiritigenin attenuates high-fat diet-induced intestinal damage by suppressing inflammation and oxidative stress and through activating Nrf2" @default.
- W4226159970 cites W1934175771 @default.
- W4226159970 cites W1969175670 @default.
- W4226159970 cites W1976513478 @default.
- W4226159970 cites W1988581085 @default.
- W4226159970 cites W1998845439 @default.
- W4226159970 cites W1999301422 @default.
- W4226159970 cites W2007636933 @default.
- W4226159970 cites W2011275458 @default.
- W4226159970 cites W2019819611 @default.
- W4226159970 cites W2020001496 @default.
- W4226159970 cites W2024346860 @default.
- W4226159970 cites W2039386910 @default.
- W4226159970 cites W2041457801 @default.
- W4226159970 cites W2048594557 @default.
- W4226159970 cites W2059429149 @default.
- W4226159970 cites W2077553363 @default.
- W4226159970 cites W2078378773 @default.
- W4226159970 cites W2080737951 @default.
- W4226159970 cites W2081216494 @default.
- W4226159970 cites W2082650560 @default.
- W4226159970 cites W2083188761 @default.
- W4226159970 cites W2088342461 @default.
- W4226159970 cites W2089262171 @default.
- W4226159970 cites W2090248973 @default.
- W4226159970 cites W2113909829 @default.
- W4226159970 cites W2131077069 @default.
- W4226159970 cites W2138411980 @default.
- W4226159970 cites W2141811439 @default.
- W4226159970 cites W2150775693 @default.
- W4226159970 cites W2155208388 @default.
- W4226159970 cites W2168526937 @default.
- W4226159970 cites W2180606871 @default.
- W4226159970 cites W2237302776 @default.
- W4226159970 cites W2330995066 @default.
- W4226159970 cites W2338087295 @default.
- W4226159970 cites W2412748597 @default.
- W4226159970 cites W2467250481 @default.
- W4226159970 cites W2582175844 @default.
- W4226159970 cites W2594772834 @default.
- W4226159970 cites W2625710117 @default.
- W4226159970 cites W2757426791 @default.
- W4226159970 cites W2767402071 @default.
- W4226159970 cites W2770769936 @default.
- W4226159970 cites W2792823858 @default.
- W4226159970 cites W2800031275 @default.
- W4226159970 cites W2800582794 @default.
- W4226159970 cites W2810092004 @default.
- W4226159970 cites W2810650444 @default.
- W4226159970 cites W2862622874 @default.
- W4226159970 cites W2895931754 @default.
- W4226159970 cites W2897484221 @default.
- W4226159970 cites W2899439955 @default.
- W4226159970 cites W2922929052 @default.
- W4226159970 cites W2953603115 @default.
- W4226159970 cites W2966171867 @default.
- W4226159970 cites W2968616252 @default.
- W4226159970 cites W2982095812 @default.
- W4226159970 cites W3010179887 @default.
- W4226159970 cites W3010677937 @default.
- W4226159970 cites W3010773257 @default.
- W4226159970 cites W3013352992 @default.
- W4226159970 cites W3015398345 @default.
- W4226159970 cites W3024275060 @default.
- W4226159970 cites W3045325746 @default.
- W4226159970 cites W3084466957 @default.
- W4226159970 cites W3088955666 @default.
- W4226159970 cites W3089174933 @default.
- W4226159970 cites W3093053350 @default.
- W4226159970 cites W3095150012 @default.
- W4226159970 cites W3126175104 @default.
- W4226159970 cites W3153958012 @default.
- W4226159970 cites W3170592680 @default.
- W4226159970 cites W3173324319 @default.
- W4226159970 cites W3194324433 @default.
- W4226159970 cites W3198174770 @default.
- W4226159970 cites W3211530674 @default.
- W4226159970 cites W4200536364 @default.
- W4226159970 cites W4244982230 @default.
- W4226159970 cites W893455078 @default.
- W4226159970 doi "https://doi.org/10.1016/j.jff.2022.105058" @default.
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