Matches in SemOpenAlex for { <https://semopenalex.org/work/W4226183896> ?p ?o ?g. }
- W4226183896 abstract "The top cause of mortality in patients with nonalcoholic fatty liver disease (NAFLD) is cardiovascular complications. However, mechanisms of NAFLD-associated vasculopathy remain understudied. Here, we show that blood outgrowth endothelial cells (BOECs) from NAFLD subjects exhibit global transcriptional upregulation of chemokines and human leukocyte antigens. In mouse models of diet-induced NAFLD, we confirm heightened endothelial expressions of CXCL12 in the aortas and the liver vasculatures, and increased retention of infiltrated leukocytes within the vessel walls. To elucidate endothelial-immune crosstalk, we performed immunoprofiling by single-cell analysis, uncovering T cell intensification in NAFLD patients. Functionally, treatment with a CXCL12-neutralizing antibody is effective at moderating the enhanced chemotactic effect of NAFLD BOECs in recruiting CD8+ T lymphocytes. Interference with the CXCL12-CXCR4 axis using a CXCR4 antagonist also averts the impact of immune cell transendothelial migration and restores endothelial barrier integrity. Clinically, we detect threefold more circulating damaged endothelial cells in NAFLD patients than in healthy controls. Our work provides insight into the modulation of interactions with effector immune cells to mitigate endothelial injury in NAFLD." @default.
- W4226183896 created "2022-05-05" @default.
- W4226183896 creator A5003086004 @default.
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- W4226183896 creator A5084768721 @default.
- W4226183896 date "2022-04-11" @default.
- W4226183896 modified "2023-10-09" @default.
- W4226183896 title "Endothelial‐immune crosstalk contributes to vasculopathy in nonalcoholic fatty liver disease" @default.
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