FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4226184441> ?p ?o ?g. }

• W4226184441 endingPage "855" @default.
• W4226184441 startingPage "847" @default.
• W4226184441 abstract "Pathological complete response after neoadjuvant chemoradiotherapy in locally advanced rectal cancer patients is related to a favorable prognosis. The identification of early biomarkers predictive of pathological complete response would help optimize the multimodality management of the patients. A panel of 11 tumor-related proteins was investigated by immunohistochemistry in the pretreatment biopsy of a group of locally advanced rectal cancer patients to identify early biomarkers of pathological complete response to neoadjuvant chemoradiotherapy. A mono-institutional retrospective cohort of 95 stage II/III locally advanced rectal cancer patients treated with neoadjuvant chemoradiotherapy and surgery was selected based on clinicalpathological characteristics and the availability of a pretreatment tumor biopsy. Eleven selected protein marker expression (MLH1, GLUT1, Ki67, CA-IX, CXCR4, COX2, CXCL12, HIF1, VEGF, CD44, and RAD51) was investigated. The optimal cutoff values were calculated by receiver operating characteristic curve analysis. Classification and regression tree analysis was performed to investigate the biomarker interaction. Patients presenting either Ki-67 or HIF1 or RAD51 below the cutoff value, or CXCR4 or COX2 above the cutoff value, were more likely to get a pathological complete response. Classification and regression tree analysis identified three groups of patients resulting from the combination of Ki-67 and CXCR4 expression. Patients with high expression of Ki-67 had the lowest chance to get a pathological complete response (18%), as compared to patients with low expression of both Ki-67 and CXCR4 (29%), and patients with low Ki-67 and high CXCR4 expression (70%). Pretreatment Ki-67, CXCR4, COX2, HIF1, and RAD51 in tumor biopsies are associated with pathological complete response after neoadjuvant chemoradiotherapy in locally advanced rectal cancer. A combined evaluation of Ki-67 and CXCR4 would increase their predictive potential. If validated, their optimal cutoff could be used to select patients for a tailored multimodality treatment." @default.
• W4226184441 created "2022-05-05" @default.
• W4226184441 creator A5000554056 @default.
• W4226184441 creator A5011458062 @default.
• W4226184441 creator A5038393792 @default.
• W4226184441 creator A5048971171 @default.
• W4226184441 creator A5050466922 @default.
• W4226184441 creator A5053612464 @default.
• W4226184441 creator A5058657353 @default.
• W4226184441 creator A5064664824 @default.
• W4226184441 creator A5067570459 @default.
• W4226184441 creator A5068048791 @default.
• W4226184441 creator A5086793612 @default.
• W4226184441 creator A5090745215 @default.
• W4226184441 date "2021-12-31" @default.
• W4226184441 modified "2023-10-16" @default.
• W4226184441 title "A Panel of Tumor Biomarkers to Predict Complete Pathological Response to Neoadjuvant Treatment in Locally Advanced Rectal Cancer" @default.
• W4226184441 cites W1867767808 @default.
• W4226184441 cites W1926135885 @default.
• W4226184441 cites W1935024879 @default.
• W4226184441 cites W1967628954 @default.
• W4226184441 cites W1974090191 @default.
• W4226184441 cites W1974698218 @default.
• W4226184441 cites W1977468182 @default.
• W4226184441 cites W1979832413 @default.
• W4226184441 cites W2034537272 @default.
• W4226184441 cites W2035367372 @default.
• W4226184441 cites W2044243545 @default.
• W4226184441 cites W2044245267 @default.
• W4226184441 cites W2045981586 @default.
• W4226184441 cites W2057901226 @default.
• W4226184441 cites W2069012164 @default.
• W4226184441 cites W2071975250 @default.
• W4226184441 cites W2083813478 @default.
• W4226184441 cites W2106014206 @default.
• W4226184441 cites W2124886112 @default.
• W4226184441 cites W2137935883 @default.
• W4226184441 cites W2144717403 @default.
• W4226184441 cites W2161875727 @default.
• W4226184441 cites W2169623192 @default.
• W4226184441 cites W2172247857 @default.
• W4226184441 cites W2207554953 @default.
• W4226184441 cites W2746193291 @default.
• W4226184441 cites W2767185612 @default.
• W4226184441 cites W2782675598 @default.
• W4226184441 cites W2793498516 @default.
• W4226184441 cites W2900137567 @default.
• W4226184441 cites W2921882373 @default.
• W4226184441 cites W2993242178 @default.
• W4226184441 cites W2996343497 @default.
• W4226184441 cites W2998097762 @default.
• W4226184441 cites W3018351558 @default.
• W4226184441 doi "https://doi.org/10.3727/096504021x16232280278813" @default.
• W4226184441 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34108073" @default.
• W4226184441 hasPublicationYear "2021" @default.
• W4226184441 type Work @default.
• W4226184441 citedByCount "3" @default.
• W4226184441 countsByYear W42261844412022 @default.
• W4226184441 countsByYear W42261844412023 @default.
• W4226184441 crossrefType "journal-article" @default.
• W4226184441 hasAuthorship W4226184441A5000554056 @default.
• W4226184441 hasAuthorship W4226184441A5011458062 @default.
• W4226184441 hasAuthorship W4226184441A5038393792 @default.
• W4226184441 hasAuthorship W4226184441A5048971171 @default.
• W4226184441 hasAuthorship W4226184441A5050466922 @default.
• W4226184441 hasAuthorship W4226184441A5053612464 @default.
• W4226184441 hasAuthorship W4226184441A5058657353 @default.
• W4226184441 hasAuthorship W4226184441A5064664824 @default.
• W4226184441 hasAuthorship W4226184441A5067570459 @default.
• W4226184441 hasAuthorship W4226184441A5068048791 @default.
• W4226184441 hasAuthorship W4226184441A5086793612 @default.
• W4226184441 hasAuthorship W4226184441A5090745215 @default.
• W4226184441 hasBestOaLocation W42261844411 @default.
• W4226184441 hasConcept C121608353 @default.
• W4226184441 hasConcept C126322002 @default.
• W4226184441 hasConcept C142724271 @default.
• W4226184441 hasConcept C143998085 @default.
• W4226184441 hasConcept C146357865 @default.
• W4226184441 hasConcept C151730666 @default.
• W4226184441 hasConcept C207886595 @default.
• W4226184441 hasConcept C2775934546 @default.
• W4226184441 hasConcept C2778292576 @default.
• W4226184441 hasConcept C2778424827 @default.
• W4226184441 hasConcept C2781197716 @default.
• W4226184441 hasConcept C526805850 @default.
• W4226184441 hasConcept C530470458 @default.
• W4226184441 hasConcept C55493867 @default.
• W4226184441 hasConcept C58471807 @default.
• W4226184441 hasConcept C71924100 @default.
• W4226184441 hasConcept C86803240 @default.
• W4226184441 hasConceptScore W4226184441C121608353 @default.
• W4226184441 hasConceptScore W4226184441C126322002 @default.
• W4226184441 hasConceptScore W4226184441C142724271 @default.
• W4226184441 hasConceptScore W4226184441C143998085 @default.
• W4226184441 hasConceptScore W4226184441C146357865 @default.
• W4226184441 hasConceptScore W4226184441C151730666 @default.
• W4226184441 hasConceptScore W4226184441C207886595 @default.
• W4226184441 hasConceptScore W4226184441C2775934546 @default.

• next