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• W4226185275 endingPage "164" @default.
• W4226185275 startingPage "143" @default.
• W4226185275 abstract "Monocarboxylate transporters (or MCTs) are widely distributed in the body and responsible for the uptake of short-chain monocarboxylates, hormones, nutrients, amino acids, as well as xenobiotics. In total, there are 14 isoforms of the MCT family (MCTs 1–14, SLC16A1–14 ), with MCTs 1–4 extensively characterized as proton-dependent transporters with a critical role in the transport of products of the glycolysis cycle (i.e., lactate and pyruvate), as well as ketone bodies, across plasma membranes. The other MCTs 5–14 have not been extensively evaluated; however, their substrate specificities have more recently begun to be characterized. Monocarboxylate substrates are also transported by two members of the SLC5A family in a sodium-dependent manner, namely, SMCT1 ( SLC5A8 ) and SMCT2 ( SLC5A12 ). This review will provide a summary of the current literature focusing on the characterization, function, and regulation of the monocarboxylate transporters, and on their roles in drug disposition and in health and disease." @default.
• W4226185275 created "2022-05-05" @default.
• W4226185275 creator A5048552069 @default.
• W4226185275 creator A5050416801 @default.
• W4226185275 date "2022-04-05" @default.
• W4226185275 modified "2023-10-16" @default.
• W4226185275 title "MONOCARBOXYLIC ACID TRANSPORTERS" @default.
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