Matches in SemOpenAlex for { <https://semopenalex.org/work/W4226193791> ?p ?o ?g. }
- W4226193791 endingPage "926" @default.
- W4226193791 startingPage "913" @default.
- W4226193791 abstract "To identify the molecular subtypes of glioblastoma multiforme (GBM) related to M2 macrophage-based prognostic genes, then to preliminarily explore their biological functions and construct immunotherapy response gene models.We used R language to analyze GBM microarray data, and other tools, including xCell and CIBERSORTx, to identify subtypes of GBM that related to M2 macrophages. The process started with the exploration of biological functions of the two subtypes by pathway analyses and GSEA, and continued with a combined procedure of constructing an M2 macrophage-related prognostic gene model and exploring the immune treatment response for GBM.A high abundance of M2 macrophages in GBM was associated with poor prognosis. According to M2 macrophage-related prognostic genes, GBM was divided into two subtypes (cluster A and cluster B). The differential gene enrichment analysis of the two clusters showed that cluster A was less enriched in M2 macrophages and had immunopotential. The M2score, which was constructed based on M2 macrophage-related prognostic genes, was not only related to the survival and prognosis of patients with GBM, but also predictive of the effectiveness of immunotherapy in these patients. This result has been effectively verified in an external data set.GBM was successfully divided into two subtypes according to M2-macrophage-related prognostic genes. In GBM, a high M2score may indicate better clinical outcome and enhancement of the immunotherapy response." @default.
- W4226193791 created "2022-05-05" @default.
- W4226193791 creator A5018239354 @default.
- W4226193791 creator A5022605132 @default.
- W4226193791 creator A5057708297 @default.
- W4226193791 creator A5063573275 @default.
- W4226193791 creator A5069239502 @default.
- W4226193791 creator A5069569173 @default.
- W4226193791 date "2022-01-01" @default.
- W4226193791 modified "2023-10-18" @default.
- W4226193791 title "Construction of Molecular Subtypes and Related Prognostic and Immune Response Models Based on M2 Macrophages in Glioblastoma" @default.
- W4226193791 cites W1966327575 @default.
- W4226193791 cites W1985664084 @default.
- W4226193791 cites W2039429561 @default.
- W4226193791 cites W2046540324 @default.
- W4226193791 cites W2063632665 @default.
- W4226193791 cites W2079487111 @default.
- W4226193791 cites W2105528101 @default.
- W4226193791 cites W2107731988 @default.
- W4226193791 cites W2113942802 @default.
- W4226193791 cites W2117692326 @default.
- W4226193791 cites W2118413367 @default.
- W4226193791 cites W2123040085 @default.
- W4226193791 cites W2146512944 @default.
- W4226193791 cites W2154526619 @default.
- W4226193791 cites W2158681922 @default.
- W4226193791 cites W2161289668 @default.
- W4226193791 cites W2169353806 @default.
- W4226193791 cites W2263206910 @default.
- W4226193791 cites W2346814081 @default.
- W4226193791 cites W2366536035 @default.
- W4226193791 cites W2524721548 @default.
- W4226193791 cites W2554863679 @default.
- W4226193791 cites W2593640726 @default.
- W4226193791 cites W2599750069 @default.
- W4226193791 cites W2610403529 @default.
- W4226193791 cites W2615301036 @default.
- W4226193791 cites W2740090202 @default.
- W4226193791 cites W2785803176 @default.
- W4226193791 cites W2795168220 @default.
- W4226193791 cites W2886498337 @default.
- W4226193791 cites W2888701389 @default.
- W4226193791 cites W2902149445 @default.
- W4226193791 cites W2903686952 @default.
- W4226193791 cites W2916545965 @default.
- W4226193791 cites W2916897461 @default.
- W4226193791 cites W2920600229 @default.
- W4226193791 cites W2951559215 @default.
- W4226193791 cites W2951880440 @default.
- W4226193791 cites W2952001873 @default.
- W4226193791 cites W2977446819 @default.
- W4226193791 cites W2980586391 @default.
- W4226193791 cites W2984698492 @default.
- W4226193791 cites W2989776766 @default.
- W4226193791 cites W3000887590 @default.
- W4226193791 cites W3002651826 @default.
- W4226193791 cites W3005738728 @default.
- W4226193791 cites W3009454722 @default.
- W4226193791 cites W3011370684 @default.
- W4226193791 cites W3012668557 @default.
- W4226193791 cites W3034998481 @default.
- W4226193791 cites W3094114963 @default.
- W4226193791 cites W3097020791 @default.
- W4226193791 cites W3099876323 @default.
- W4226193791 cites W3108593458 @default.
- W4226193791 cites W3109713080 @default.
- W4226193791 cites W3111111518 @default.
- W4226193791 cites W3119640668 @default.
- W4226193791 cites W3130587337 @default.
- W4226193791 cites W3134862796 @default.
- W4226193791 cites W3155161680 @default.
- W4226193791 cites W3174246647 @default.
- W4226193791 cites W3179907307 @default.
- W4226193791 cites W3205390641 @default.
- W4226193791 doi "https://doi.org/10.2147/ijgm.s343152" @default.
- W4226193791 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35115817" @default.
- W4226193791 hasPublicationYear "2022" @default.
- W4226193791 type Work @default.
- W4226193791 citedByCount "1" @default.
- W4226193791 countsByYear W42261937912022 @default.
- W4226193791 crossrefType "journal-article" @default.
- W4226193791 hasAuthorship W4226193791A5018239354 @default.
- W4226193791 hasAuthorship W4226193791A5022605132 @default.
- W4226193791 hasAuthorship W4226193791A5057708297 @default.
- W4226193791 hasAuthorship W4226193791A5063573275 @default.
- W4226193791 hasAuthorship W4226193791A5069239502 @default.
- W4226193791 hasAuthorship W4226193791A5069569173 @default.
- W4226193791 hasBestOaLocation W42261937911 @default.
- W4226193791 hasConcept C104317684 @default.
- W4226193791 hasConcept C143998085 @default.
- W4226193791 hasConcept C150194340 @default.
- W4226193791 hasConcept C202751555 @default.
- W4226193791 hasConcept C203014093 @default.
- W4226193791 hasConcept C2776194525 @default.
- W4226193791 hasConcept C2777701055 @default.
- W4226193791 hasConcept C2779244956 @default.
- W4226193791 hasConcept C502942594 @default.
- W4226193791 hasConcept C54355233 @default.