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• W4226200904 abstract "Adrenal masses are a frequent finding in clinical practice. Many of them are incidentally discovered with a prevalence of 4% in patients undergoing abdominal anatomic imaging and require a differential diagnosis. Biochemical tests, evaluating hormonal production of both adrenal cortex and medulla (in particular, mineralocorticoids, glucocorticoids and catecholamines), have a primary importance in distinguishing functional or non-functional lesions. Conventional imaging techniques, in particular computerized tomography (CT) and magnetic resonance imaging (MRI), are required to differentiate between benign and malignant lesions according to their appearance (size stability, contrast enhanced CT and/or chemical shift on MRI). In selected patients, functional imaging is a non-invasive tool able to explore the metabolic pathways involved thus providing additional diagnostic information. Several single photon emission tomography (SPET) and positron emission tomography (PET) radiopharmaceuticals have been developed and are available, each of them suitable for studying specific pathological conditions. In functional masses causing hypersecreting diseases (mainly adrenal hypercortisolism, primary hyperaldosteronism and pheochromocytoma), functional imaging can lateralize the involvement and guide the therapeutic strategy in both unilateral and bilateral lesions. In non-functioning adrenal masses with inconclusive imaging findings at CT/MR, [18F]-FDG evaluation of tumor metabolism can be helpful to characterize them by distinguishing between benign nodules and primary malignant adrenal disease (mainly adrenocortical carcinoma), thus modulating the surgical approach. In oncologic patients, [18F]-FDG uptake can differentiate between benign nodule and adrenal metastasis from extra-adrenal primary malignancies." @default.
• W4226200904 created "2022-05-05" @default.
• W4226200904 creator A5021128491 @default.
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• W4226200904 creator A5068167563 @default.
• W4226200904 creator A5083292228 @default.
• W4226200904 date "2022-05-01" @default.
• W4226200904 modified "2023-10-18" @default.
• W4226200904 title "Integration of molecular imaging in the personalized approach of patients with adrenal masses" @default.
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• W4226200904 doi "https://doi.org/10.23736/s1824-4785.22.03449-5" @default.
• W4226200904 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35343669" @default.
• W4226200904 hasPublicationYear "2022" @default.
• W4226200904 type Work @default.

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