FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4226232391> ?p ?o ?g. }

• W4226232391 endingPage "579" @default.
• W4226232391 startingPage "575" @default.
• W4226232391 abstract "DNA hydroxymethylation may be induced by oxidative stress in lupus patients, so we investigated the association between DNA hydroxymethylation and demethylation with the antioxidant response. A case–control study was performed including lupus patients and matched healthy controls. Serum concentration of glutathione (GSH), glutathione disulphide (GSSG), superoxide dismutase (SOD) and total antioxidant capacity (TAC), 5-mC and 5-hmC were determined. One hundred and forty-two patients and 34 controls were included. 5-hmC levels were lower in SLE patients than in controls. GSH and GSSG values were lower in patients, while SOD levels were higher in patients. TAC did not show significant differences, but higher demethylation and lower hydroxydemethylation were associated to increased TAC values. Lower demethylation was associated with cytopenia and lower hydroxymethylation with longer course of the disease. Lower levels of GSH and GSSG and higher SOD values were associated with accumulated damage assessed by SLICC-ACR. Lower hydroxymethylation in patients than in controls was observed. Moreover, higher demethylation and lower hydroxymethylation leads to high TAC levels. DNA hydroxymethylation seems to be related to longer course of the disease. La hidroximetilación del ADN puede estar inducida por el estrés oxidativo en pacientes de lupus, por lo que estudiamos la asociación entre hidroximetilación del ADN y desmetilación sin respuesta antioxidante. Se realizó un control de casos que incluyó a pacientes de lupus pareados con controles sanos. Se calcularon la concentración sérica de glutatión (GSH), glutatión disulfuro (GSSG), superóxido dismutasa (SOD), capacidad antioxidante total (CAT), 5-mC y 5-hmC. Se incluyeron 142 pacientes y 34 controles. Los niveles de 5-hmC fueron menores en el grupo de pacientes de LES que en el de controles. Los valores de GSH y GSSG fueron menores en el grupo de pacientes, mientras que los valores de SOD fueron superiores en el grupo de pacientes. La CAT no reflejó diferencias significativas, pero el incremento de desmetilación y la disminución de hidroximetilación estuvieron asociados al incremento de los valores de la CAT. La disminución de la desmetilación estuvo asociada a citopenia, y la disminución de la hidroximetilación a un curso más corto de la enfermedad. Los niveles menores de GSH y GSSG, y los valores superiores de SOD estuvieron asociados a una acumulación del daño, según lo evaluado mediante SLICC-ACR. Se observó menor hidroximetilación en los pacientes que en los controles. Además, el incremento de la desmetilación y la disminución de la hidroximetilación conllevan unos altos niveles de CAT. La hidroximetilación del ADN parece estar relacionada con un curso más largo de la enfermedad." @default.
• W4226232391 created "2022-05-05" @default.
• W4226232391 creator A5005204305 @default.
• W4226232391 creator A5012906286 @default.
• W4226232391 creator A5014847194 @default.
• W4226232391 creator A5033087285 @default.
• W4226232391 creator A5036882505 @default.
• W4226232391 creator A5066820545 @default.
• W4226232391 date "2021-12-01" @default.
• W4226232391 modified "2023-10-16" @default.
• W4226232391 title "Decreased DNA hydroxymethylation and increased DNA demethylation are associated with high antioxidant response in systemic lupus erythematosus patients" @default.
• W4226232391 cites W1967244099 @default.
• W4226232391 cites W2005568666 @default.
• W4226232391 cites W2048791273 @default.
• W4226232391 cites W2065505163 @default.
• W4226232391 cites W2083673932 @default.
• W4226232391 cites W2089200603 @default.
• W4226232391 cites W2300770373 @default.
• W4226232391 cites W2972002224 @default.
• W4226232391 cites W776181457 @default.
• W4226232391 doi "https://doi.org/10.1016/j.medcle.2020.10.020" @default.
• W4226232391 hasPublicationYear "2021" @default.
• W4226232391 type Work @default.
• W4226232391 citedByCount "0" @default.
• W4226232391 crossrefType "journal-article" @default.
• W4226232391 hasAuthorship W4226232391A5005204305 @default.
• W4226232391 hasAuthorship W4226232391A5012906286 @default.
• W4226232391 hasAuthorship W4226232391A5014847194 @default.
• W4226232391 hasAuthorship W4226232391A5033087285 @default.
• W4226232391 hasAuthorship W4226232391A5036882505 @default.
• W4226232391 hasAuthorship W4226232391A5066820545 @default.
• W4226232391 hasConcept C104317684 @default.
• W4226232391 hasConcept C126322002 @default.
• W4226232391 hasConcept C134018914 @default.
• W4226232391 hasConcept C150194340 @default.
• W4226232391 hasConcept C153911025 @default.
• W4226232391 hasConcept C16824249 @default.
• W4226232391 hasConcept C181199279 @default.
• W4226232391 hasConcept C185592680 @default.
• W4226232391 hasConcept C190727270 @default.
• W4226232391 hasConcept C202199734 @default.
• W4226232391 hasConcept C203014093 @default.
• W4226232391 hasConcept C2775838275 @default.
• W4226232391 hasConcept C2776151105 @default.
• W4226232391 hasConcept C2776912625 @default.
• W4226232391 hasConcept C2778004101 @default.
• W4226232391 hasConcept C2778760513 @default.
• W4226232391 hasConcept C2779134260 @default.
• W4226232391 hasConcept C2993539680 @default.
• W4226232391 hasConcept C538909803 @default.
• W4226232391 hasConcept C55493867 @default.
• W4226232391 hasConcept C71924100 @default.
• W4226232391 hasConcept C86803240 @default.
• W4226232391 hasConceptScore W4226232391C104317684 @default.
• W4226232391 hasConceptScore W4226232391C126322002 @default.
• W4226232391 hasConceptScore W4226232391C134018914 @default.
• W4226232391 hasConceptScore W4226232391C150194340 @default.
• W4226232391 hasConceptScore W4226232391C153911025 @default.
• W4226232391 hasConceptScore W4226232391C16824249 @default.
• W4226232391 hasConceptScore W4226232391C181199279 @default.
• W4226232391 hasConceptScore W4226232391C185592680 @default.
• W4226232391 hasConceptScore W4226232391C190727270 @default.
• W4226232391 hasConceptScore W4226232391C202199734 @default.
• W4226232391 hasConceptScore W4226232391C203014093 @default.
• W4226232391 hasConceptScore W4226232391C2775838275 @default.
• W4226232391 hasConceptScore W4226232391C2776151105 @default.
• W4226232391 hasConceptScore W4226232391C2776912625 @default.
• W4226232391 hasConceptScore W4226232391C2778004101 @default.
• W4226232391 hasConceptScore W4226232391C2778760513 @default.
• W4226232391 hasConceptScore W4226232391C2779134260 @default.
• W4226232391 hasConceptScore W4226232391C2993539680 @default.
• W4226232391 hasConceptScore W4226232391C538909803 @default.
• W4226232391 hasConceptScore W4226232391C55493867 @default.
• W4226232391 hasConceptScore W4226232391C71924100 @default.
• W4226232391 hasConceptScore W4226232391C86803240 @default.
• W4226232391 hasIssue "12" @default.
• W4226232391 hasLocation W42262323911 @default.
• W4226232391 hasOpenAccess W4226232391 @default.
• W4226232391 hasPrimaryLocation W42262323911 @default.
• W4226232391 hasRelatedWork W1964799598 @default.
• W4226232391 hasRelatedWork W2067568257 @default.
• W4226232391 hasRelatedWork W2143075629 @default.
• W4226232391 hasRelatedWork W2213996271 @default.
• W4226232391 hasRelatedWork W2382440703 @default.
• W4226232391 hasRelatedWork W2579705245 @default.
• W4226232391 hasRelatedWork W2706317929 @default.
• W4226232391 hasRelatedWork W2766233192 @default.
• W4226232391 hasRelatedWork W3200659209 @default.
• W4226232391 hasRelatedWork W3214998341 @default.
• W4226232391 hasVolume "157" @default.
• W4226232391 isParatext "false" @default.
• W4226232391 isRetracted "false" @default.
• W4226232391 workType "article" @default.