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- W4226244246 abstract "The positive impact of meditation on human well-being is well documented, yet its molecular mechanisms are incompletely understood. We applied a comprehensive systems biology approach starting with whole-blood gene expression profiling combined with multilevel bioinformatic analyses to characterize the coexpression, transcriptional, and protein-protein interaction networks to identify a meditation-specific core network after an advanced 8-d Inner Engineering retreat program. We found the response to oxidative stress, detoxification, and cell cycle regulation pathways were down-regulated after meditation. Strikingly, 220 genes directly associated with immune response, including 68 genes related to interferon signaling, were up-regulated, with no significant expression changes in the inflammatory genes. This robust meditation-specific immune response network is significantly dysregulated in multiple sclerosis and severe COVID-19 patients. The work provides a foundation for understanding the effect of meditation and suggests that meditation as a behavioral intervention can voluntarily and nonpharmacologically improve the immune response for treating various conditions associated with excessive or persistent inflammation with a dampened immune system profile." @default.
- W4226244246 created "2022-05-05" @default.
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- W4226244246 date "2021-12-13" @default.
- W4226244246 modified "2023-09-26" @default.
- W4226244246 title "Large-scale genomic study reveals robust activation of the immune system following advanced Inner Engineering meditation retreat" @default.
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- W4226244246 doi "https://doi.org/10.1073/pnas.2110455118" @default.
- W4226244246 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34907015" @default.
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