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- W4226244254 abstract "In the present study, the surface of halloysite nanotubes (Hal) grafted with a reactive β-cyclodextrin based monomer carrying vinyl carboxylic acid functional groups (MAH-β-CD) was designed and prepared through free radical copolymerization (Hal-V/MAH-β-CD) for anticancer drug delivery. Doxorubicin (DOX) was loaded effectively to the Hal-V/MAH-β-CD nanocarrier via physical adsorption with high loading efficiency. Drug release investigations demonstrated that [email protected] Hal-V/MAH-β-CD nanocarrier has a high drug release at cancerous condition (pH 5.4). From MTT assay, it was found that [email protected]/MAH-β-CD exerted great anticancer effect against MCF-7 breast cancer cells. The hemolysis experiments exhibited that nanocarrier has no remarkable hemolytic effect on human red blood cells (HRBCs), indicating the blood compatibility of the nanocarrier. Taken together, the newly prepared Hal-V/MAH-β-CD nanocarrier can be considered as a promising tool for DOX delivery to the MCF-7 breast cancer cells." @default.
- W4226244254 created "2022-05-05" @default.
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- W4226244254 date "2022-08-01" @default.
- W4226244254 modified "2023-09-23" @default.
- W4226244254 title "Synthesis and characterization of novel hybrid nanomaterials based on β-cyclodextrine grafted halloysite nanotubes for delivery of doxorubicin to MCF-7 cell line" @default.
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- W4226244254 doi "https://doi.org/10.1016/j.molstruc.2022.133004" @default.
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