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• W4226244879 abstract "The prevalence of diabetic microvascular diseases has increased significantly worldwide, the most common of which are diabetic nephropathy (DN) and diabetic retinopathy (DR). Microvascular endothelial cells are thought to be major targets of hyperglycemic damage, while the underlying mechanism of diffuse endothelial dysfunction in multiple organs needs to be further investigated.The aim of this study is to explore the endothelial dysfunction mechanisms of serum exosomes (SExos) extracted from DR and DN (DRDN) patients.In this study, human glomerular endothelial cells (HGECs) were used as the cell model. Metabolomics ultraperformance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) and proteomics tandem mass tag (TMT)-based liquid chromatography-tandem mass spectrometry (LC-MS/MS) together with bioinformatics, the correlation analysis, and the joint pathway analysis were employed to discover the underlying mechanisms of endothelial dysfunction caused by patient's SExos.It can be assumed that serum exosomes extracted by DRDN patients might cause endothelial dysfunction mainly by upregulating alpha subunit of the coagulation factor fibrinogen (FIBA) and downregulating 1-methylhistidine (1-MH). Bioinformatics analysis pointed to an important role in reducing excess cysteine and methionine metabolism.FIBA overexpression and 1-MH loss may be linked to the pathogenicity of diabetic endothelial dysfunction in DR/DN, implying that a cohort study is needed to further investigate the role of FIBA and 1-MH in the development of DN and DR, as well as the related pathways between the two proteins." @default.
• W4226244879 created "2022-05-05" @default.
• W4226244879 creator A5032539923 @default.
• W4226244879 creator A5042085716 @default.
• W4226244879 creator A5070792980 @default.
• W4226244879 date "2022-03-25" @default.
• W4226244879 modified "2023-10-14" @default.
• W4226244879 title "Integration of Metabolomics and Proteomics in Exploring the Endothelial Dysfunction Mechanism Induced by Serum Exosomes From Diabetic Retinopathy and Diabetic Nephropathy Patients" @default.
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• W4226244879 doi "https://doi.org/10.3389/fendo.2022.830466" @default.
• W4226244879 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35399949" @default.
• W4226244879 hasPublicationYear "2022" @default.
• W4226244879 type Work @default.
• W4226244879 citedByCount "8" @default.
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• W4226244879 crossrefType "journal-article" @default.
• W4226244879 hasAuthorship W4226244879A5032539923 @default.
• W4226244879 hasAuthorship W4226244879A5042085716 @default.
• W4226244879 hasAuthorship W4226244879A5070792980 @default.

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