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- W4226247923 endingPage "1223" @default.
- W4226247923 startingPage "1209" @default.
- W4226247923 abstract "Stem cell-like memory T cells (Tscm), are a newly defined memory T cell subset with characteristics of long life span, consistent self-renewing, rapid differentiation into effector T cells, and apoptosis resistance. These features indicate that Tscm have great therapeutic or preventive purposes, including being applied in chimeric Ag receptor-engineered T cells, TCR gene-modified T cells, and vaccines. However, the little knowledge about Tscm development restrains their applications. Strength and duration of TCR signaling, cytokines and metabolism in the T cells during activation all influence the Tscm development via regulating transcriptional factors and cell signaling pathways. Here, we summarize the molecular and cellular pathways involving Tscm differentiation, and its clinical application for cancer immunotherapy and prevention." @default.
- W4226247923 created "2022-05-05" @default.
- W4226247923 creator A5011264725 @default.
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- W4226247923 creator A5061375711 @default.
- W4226247923 creator A5069362448 @default.
- W4226247923 creator A5079025070 @default.
- W4226247923 date "2021-08-17" @default.
- W4226247923 modified "2023-09-29" @default.
- W4226247923 title "Stem cell-like memory T cells: The generation and application" @default.
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